scholarly journals Point-of-Care Diagnostics: Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism (Adv. Funct. Mater. 34/2018)

2018 ◽  
Vol 28 (34) ◽  
pp. 1870236
Author(s):  
Hyun-Ouk Kim ◽  
Woonsung Na ◽  
Minjoo Yeom ◽  
Jihye Choi ◽  
Jihye Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Host Cell ◽  
Rapid Detection ◽  
Point Of Care ◽  
Cell Entry ◽  
Viral Fusion ◽  
Highly Pathogenic ◽  
Point Of Care Diagnostics ◽  
Entry Mechanism

scholarly journals Host Cell Mimic Polymersomes for Rapid Detection of Highly Pathogenic Influenza Virus via a Viral Fusion and Cell Entry Mechanism

2018 ◽  
Vol 28 (34) ◽  
pp. 1800960 ◽  
Author(s):  
Hyun-Ouk Kim ◽  
Woonsung Na ◽  
Minjoo Yeom ◽  
Jihye Choi ◽  
Jihye Kim ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Host Cell ◽  
Rapid Detection ◽  
Cell Entry ◽  
Viral Fusion ◽  
Highly Pathogenic ◽  
Entry Mechanism

scholarly journals Genetic Analysis of H1N1 Influenza Virus from Throat Swab Samples in a Microfluidic System for Point-of-Care Diagnostics

2011 ◽  
Vol 133 (23) ◽  
pp. 9129-9135 ◽  
Author(s):  
B. Scott Ferguson ◽  
Steven F. Buchsbaum ◽  
Ting-Ting Wu ◽  
Kuangwen Hsieh ◽  
Yi Xiao ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Genetic Analysis ◽  
Throat Swab ◽  
Point Of Care ◽  
H1n1 Influenza ◽  
Microfluidic System ◽  
H1n1 Influenza Virus ◽  
Point Of Care Diagnostics

scholarly journals 2019 Novel Coronavirus Disease (COVID-19): Paving the Road for Rapid Detection and Point-of-Care Diagnostics

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 306 ◽  
Author(s):  
Trieu Nguyen ◽  
Dang Duong Bang ◽  
Anders Wolff
Keyword(s):  
Rapid Detection ◽  
Point Of Care ◽  
Potential Candidate ◽  
The Road ◽  
Point Of Care Diagnostics ◽  
Novel Coronavirus

We believe a point-of-care (PoC) device for the rapid detection of the 2019 novel Coronavirus (SARS-CoV-2) is crucial and urgently needed. With this perspective, we give suggestions regarding a potential candidate for the rapid detection of the coronavirus disease 2019 (COVID-19), as well as factors for the preparedness and response to the outbreak of the COVID-19.

scholarly journals Infectious Cell Entry Mechanism of Influenza Virus

1982 ◽  
Vol 43 (1) ◽  
pp. 284-293 ◽  
Author(s):  
Akihiko Yoshimura ◽  
Kazumichi Kuroda ◽  
Kazunori Kawasaki ◽  
Shohei Yamashina ◽  
Toyozo Maeda ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Cell Entry ◽  
Entry Mechanism

scholarly journals Contribution of Nanotechnology in the Fight Against COVID-19

2020 ◽  
Vol 11 (1) ◽  
pp. 8233-8241 ◽  
Keyword(s):  
Rapid Detection ◽  
Vaccine Development ◽  
Point Of Care ◽  
Advanced Technology ◽  
Development Research ◽  
New Materials ◽  
The Earth ◽  
Point Of Care Diagnostics ◽  
Funding Agencies ◽  
New Research

Coronavirus disease (COVID-19) is a respiratory infectious disease caused by a newly discovered virus strain, severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2). This pandemic spread quickly across nations with a high mortality rate in immunocompromised patients. This contagious disease posed a serious threat to health systems. It impacted the continents of the earth in a way that could not have been predicted. Therefore, many leading funding agencies announced the call for proposal to diagnosis and treatment of COVID-19 pandemic using advanced technology-based methods, including nanotechnology. The researchers coming from the nanotechnology community can contribute their efforts to cope with COVID-19. As a community member of nanotechnology, we suggest some new research targets that can be designed and improved, optimized, and developed the existing/new materials in the sub-field of diagnostics and healthcare of nanotechnology. The potential research targets to fight against COVID-19 includes Point-of-care diagnostics (POCD), surveillance and monitoring, novel therapeutics, vaccine development, research, and development, repurposing existing drugs with potential therapeutic applications, development of antiviral nanocoating/antimicrobial spray-based coating for PPE, magnetic nanoparticles and viral RNA and rapid detection kits.

scholarly journals Lassa Virus Cell Entry Reveals New Aspects of Virus-Host Cell Interaction

2016 ◽  
Vol 91 (4) ◽  
Author(s):  
Giulia Torriani ◽  
Clara Galan-Navarro ◽  
Stefan Kunz
Keyword(s):  
Host Cell ◽  
Viral Entry ◽  
Molecular Mechanisms ◽  
Cell Interaction ◽  
Cell Entry ◽  
Lassa Virus ◽  
Human Pathogen ◽  
Highly Pathogenic ◽  
Receptor Recognition ◽  
Host Cell Interaction

ABSTRACT Viral entry represents the first step of every viral infection and is a determinant for the host range and disease potential of a virus. Here, we review the latest developments on cell entry of the highly pathogenic Old World arenavirus Lassa virus, providing novel insights into the complex virus-host cell interaction of this important human pathogen. We will cover new discoveries on the molecular mechanisms of receptor recognition, endocytosis, and the use of late endosomal entry factors.

Characterization of the host cell entry of filamentous influenza virus

2005 ◽  
Vol 150 (9) ◽  
pp. 1783-1796 ◽  
Author(s):  
S. B. Sieczkarski ◽  
G. R. Whittaker
Keyword(s):  
Influenza Virus ◽  
Host Cell ◽  
Cell Entry ◽  
Host Cell Entry

scholarly journals Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Naoki Kajiwara ◽  
Namiko Nomura ◽  
Masako Ukaji ◽  
Naoki Yamamoto ◽  
Michinori Kohara ◽  
...  
Keyword(s):  
Amino Acids ◽  
Influenza Virus ◽  
Sialic Acid ◽  
Avian Influenza ◽  
Highly Pathogenic Avian Influenza ◽  
Cell Entry ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Cell Penetrating ◽  
Pathogenic Avian Influenza Virus

Abstract H5N1 highly pathogenic avian influenza virus (HPAIV) poses a huge threat to public health and the global economy. These viruses cause systemic infection in poultry and accidental human infection leads to severe pneumonia, associated with high mortality rates. The hemagglutinin (HA) of H5N1 HPAIV possesses multiple basic amino acids, as in the sequence RERRRKKR at the cleavage site; however, the role of this motif is not fully understood. Here, we showed that a 33-amino acid long peptide derived from HA of H5N1 HPAIV (HA314-46) has the potential to penetrate various cells and lung tissue through a sialic acid-independent endocytotic pathway. Mutant peptide analyses revealed that the cysteine residue at position 318 and multiple basic amino acids were essential for the cell-penetrating activity. Moreover, reassortant viruses possessing H5 HA could enter sialic acid-deficient cells, and virus internalisation was facilitated by cleavage with recombinant furin. Thus, our findings demonstrate that the HA314-46 motif exhibits cell-penetrating activity through a sialic acid-independent cell entry mechanism.

scholarly journals Functionalized TiO2 Nanotube-Based Electrochemical Biosensor for Rapid Detection of SARS-CoV-2

Sensors ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 5871 ◽  
Author(s):  
Bhaskar S. Vadlamani ◽  
Timsy Uppal ◽  
Subhash C. Verma ◽  
Mano Misra
Keyword(s):  
Rapid Detection ◽  
Point Of Care ◽  
Low Cost ◽  
Viral Disease ◽  
Electrochemical Anodization ◽  
Prophylactic Measure ◽  
Point Of Care Diagnostics ◽  
First Case ◽  
One Step ◽  
Asymptomatic Individuals

The COronaVIrus Disease (COVID-19) is a newly emerging viral disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rapid increase in the number of COVID-19 cases worldwide led the WHO to declare a pandemic within a few months after the first case of infection. Due to the lack of a prophylactic measure to control the virus infection and spread, early diagnosis and quarantining of infected as well as the asymptomatic individuals are necessary for the containment of this pandemic. However, the current methods for SARS-CoV-2 diagnosis are expensive and time consuming, although some promising and inexpensive technologies are becoming available for emergency use. In this work, we report the synthesis of a cheap, yet highly sensitive, cobalt-functionalized TiO2 nanotubes (Co-TNTs)-based electrochemical sensor for rapid detection of SARS-CoV-2 through sensing the spike (receptor binding domain (RBD)) present on the surface of the virus. A simple, low-cost, and one-step electrochemical anodization route was used for synthesizing TNTs, followed by an incipient wetting method for cobalt functionalization of the TNTs platform, which was connected to a potentiostat for data collection. This sensor specifically detected the S-RBD protein of SARS-CoV-2 even at very low concentration (range of 14 to 1400 nM (nano molar)). Additionally, our sensor showed a linear response in the detection of viral protein over the concentration range. Thus, our Co-TNT sensor is highly effective in detecting SARS-CoV-2 S-RBD protein in approximately 30 s, which can be explored for developing a point of care diagnostics for rapid detection of SARS-CoV-2 in nasal secretions and saliva samples.

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