scholarly journals High‐frequency oscillations mirror severity of human temporal lobe seizures

2019 ◽  
Vol 6 (12) ◽  
pp. 2479-2488 ◽  
Author(s):  
Jan Schönberger ◽  
Nadja Birk ◽  
Daniel Lachner‐Piza ◽  
Matthias Dümpelmann ◽  
Andreas Schulze‐Bonhage ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Temporal Lobe Seizures ◽  
Human Temporal Lobe

scholarly journals Automatic vs. Manual Detection of High Frequency Oscillations in Intracranial Recordings From the Human Temporal Lobe

2020 ◽  
Vol 11 ◽  
Author(s):  
Aljoscha Thomschewski ◽  
Nathalie Gerner ◽  
Patrick B. Langthaler ◽  
Eugen Trinka ◽  
Arne C. Bathke ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Intracranial Recordings ◽  
Human Temporal Lobe

Spatial localization and time-dependant changes of electrographic high frequency oscillations in human temporal lobe epilepsy

Epilepsia ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 605-616 ◽  
Author(s):  
Houman Khosravani ◽  
Nikhil Mehrotra ◽  
Michael Rigby ◽  
Walter J. Hader ◽  
C. Robert Pinnegar ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Spatial Localization ◽  
High Frequency Oscillations ◽  
Human Temporal Lobe

scholarly journals High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings

Brain ◽  
2008 ◽  
Vol 131 (4) ◽  
pp. 928-937 ◽  
Author(s):  
Greg A. Worrell ◽  
Andrew B. Gardner ◽  
S. Matt Stead ◽  
Sanqing Hu ◽  
Steve Goerss ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Human Temporal Lobe

scholarly journals Role of ictal baseline shifts and ictal high-frequency oscillations in stereo-electroencephalography analysis of mesial temporal lobe seizures

Epilepsia ◽  
2014 ◽  
Vol 55 (5) ◽  
pp. 690-698 ◽  
Author(s):  
Shasha Wu ◽  
Hari Prasad Kunhi Veedu ◽  
Samden D. Lhatoo ◽  
Mohamad Z. Koubeissi ◽  
Jonathan P. Miller ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Temporal Lobe Seizures ◽  
Mesial Temporal Lobe

scholarly journals Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy

Epilepsia ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Shennan Aibel Weiss ◽  
Catalina Alvarado-Rojas ◽  
Anatol Bragin ◽  
Eric Behnke ◽  
Tony Fields ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Local Field ◽  
Unit Activity ◽  
High Frequency ◽  
Local Field Potentials ◽  
Mesial Temporal Lobe Epilepsy ◽  
Field Potentials ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

scholarly journals Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy

2014 ◽  
Vol 67 ◽  
pp. 97-106 ◽  
Author(s):  
Pariya Salami ◽  
Maxime Lévesque ◽  
Ruba Benini ◽  
Charles Behr ◽  
Jean Gotman ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Interictal Spikes ◽  
High Frequency Oscillations

Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy

2019 ◽  
Vol 130 (7) ◽  
pp. 1151-1159 ◽  
Author(s):  
Pavel Řehulka ◽  
Jan Cimbálník ◽  
Martin Pail ◽  
Jan Chrastina ◽  
Markéta Hermanová ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

scholarly journals Ictal Occurrence of High-Frequency Oscillations Correlates With Seizure Severity in a Rat Model of Temporal Lobe Epilepsy

2021 ◽  
Vol 15 ◽  
Author(s):  
Nadja Birk ◽  
Jan Schönberger ◽  
Karin Helene Somerlik-Fuchs ◽  
Andreas Schulze-Bonhage ◽  
Julia Jacobs
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Epileptic Activity ◽  
Seizure Severity ◽  
Chronic Epilepsy ◽  
High Frequency Oscillations

High-frequency oscillations (HFOs, ripples 80–250 Hz, fast ripples 250–500 Hz) are biomarkers of epileptic tissue. They are most commonly observed over areas generating seizures and increase in occurrence during the ictal compared to the interictal period. It has been hypothesized that their rate correlates with the severity of epilepsy and seizure in affected individuals. In the present study, it was aimed to investigate whether the HFO count mirrors the observed behavioral seizure severity using a kainate rat model for temporal lobe epilepsy. Seizures were selected during the chronic epilepsy phase of this model and classified by behavioral severity according to the Racine scale. Seizures with Racine scale 5&6 were considered generalized and severe. HFOs were marked in 24 seizures during a preictal, ictal, and postictal EEG segment. The duration covered by the HFO during these different segments was analyzed and compared between mild and severe seizures. HFOs were significantly increased during ictal periods (p < 0.001) and significantly decreased during postictal periods (p < 0.03) compared to the ictal segment. Ictal ripples (p = 0.04) as well as fast ripples (p = 0.02) were significantly higher in severe seizures compared to mild seizures. The present study demonstrates that ictal HFO occurrence mirrors seizure severity in a chronic focal epilepsy model in rats. This is similar to recent observations in patients with refractory mesio-temporal lobe epilepsy. Moreover, postictal HFO decrease might reflect postictal inhibition of epileptic activity. Overall results provide additional evidence that HFOs can be used as biomarkers for measuring seizure severity in epilepsy.

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