scholarly journals Cellular correlates of epileptic spikes with high-frequency oscillations in the human temporal lobe

Brain ◽  
2021 ◽  
Author(s):  
Gilles Huberfeld ◽  
Michel Le Van Quyen
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Epileptic Spikes ◽  
Human Temporal Lobe

scholarly journals Automatic vs. Manual Detection of High Frequency Oscillations in Intracranial Recordings From the Human Temporal Lobe

2020 ◽  
Vol 11 ◽  
Author(s):  
Aljoscha Thomschewski ◽  
Nathalie Gerner ◽  
Patrick B. Langthaler ◽  
Eugen Trinka ◽  
Arne C. Bathke ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Intracranial Recordings ◽  
Human Temporal Lobe

Spatial localization and time-dependant changes of electrographic high frequency oscillations in human temporal lobe epilepsy

Epilepsia ◽  
2009 ◽  
Vol 50 (4) ◽  
pp. 605-616 ◽  
Author(s):  
Houman Khosravani ◽  
Nikhil Mehrotra ◽  
Michael Rigby ◽  
Walter J. Hader ◽  
C. Robert Pinnegar ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Spatial Localization ◽  
High Frequency Oscillations ◽  
Human Temporal Lobe

scholarly journals High-frequency oscillations in human temporal lobe: simultaneous microwire and clinical macroelectrode recordings

Brain ◽  
2008 ◽  
Vol 131 (4) ◽  
pp. 928-937 ◽  
Author(s):  
Greg A. Worrell ◽  
Andrew B. Gardner ◽  
S. Matt Stead ◽  
Sanqing Hu ◽  
Steve Goerss ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Human Temporal Lobe

scholarly journals High‐frequency oscillations mirror severity of human temporal lobe seizures

2019 ◽  
Vol 6 (12) ◽  
pp. 2479-2488 ◽  
Author(s):  
Jan Schönberger ◽  
Nadja Birk ◽  
Daniel Lachner‐Piza ◽  
Matthias Dümpelmann ◽  
Andreas Schulze‐Bonhage ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Temporal Lobe Seizures ◽  
Human Temporal Lobe

scholarly journals Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy

Epilepsia ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Shennan Aibel Weiss ◽  
Catalina Alvarado-Rojas ◽  
Anatol Bragin ◽  
Eric Behnke ◽  
Tony Fields ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Local Field ◽  
Unit Activity ◽  
High Frequency ◽  
Local Field Potentials ◽  
Mesial Temporal Lobe Epilepsy ◽  
Field Potentials ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

scholarly journals Dynamics of interictal spikes and high-frequency oscillations during epileptogenesis in temporal lobe epilepsy

2014 ◽  
Vol 67 ◽  
pp. 97-106 ◽  
Author(s):  
Pariya Salami ◽  
Maxime Lévesque ◽  
Ruba Benini ◽  
Charles Behr ◽  
Jean Gotman ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Interictal Spikes ◽  
High Frequency Oscillations

Automatic detection of high-frequency-oscillations and their sub-groups co-occurring with interictal-epileptic-spikes

2020 ◽  
Vol 17 (1) ◽  
pp. 016030 ◽  
Author(s):  
Daniel Lachner-Piza ◽  
Julia Jacobs ◽  
Jonas C Bruder ◽  
Andreas Schulze-Bonhage ◽  
Thomas Stieglitz ◽  
...  
Keyword(s):  
High Frequency ◽  
Automatic Detection ◽  
High Frequency Oscillations ◽  
Epileptic Spikes

Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy

2019 ◽  
Vol 130 (7) ◽  
pp. 1151-1159 ◽  
Author(s):  
Pavel Řehulka ◽  
Jan Cimbálník ◽  
Martin Pail ◽  
Jan Chrastina ◽  
Markéta Hermanová ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

scholarly journals Ictal Occurrence of High-Frequency Oscillations Correlates With Seizure Severity in a Rat Model of Temporal Lobe Epilepsy

2021 ◽  
Vol 15 ◽  
Author(s):  
Nadja Birk ◽  
Jan Schönberger ◽  
Karin Helene Somerlik-Fuchs ◽  
Andreas Schulze-Bonhage ◽  
Julia Jacobs
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Epileptic Activity ◽  
Seizure Severity ◽  
Chronic Epilepsy ◽  
High Frequency Oscillations

High-frequency oscillations (HFOs, ripples 80–250 Hz, fast ripples 250–500 Hz) are biomarkers of epileptic tissue. They are most commonly observed over areas generating seizures and increase in occurrence during the ictal compared to the interictal period. It has been hypothesized that their rate correlates with the severity of epilepsy and seizure in affected individuals. In the present study, it was aimed to investigate whether the HFO count mirrors the observed behavioral seizure severity using a kainate rat model for temporal lobe epilepsy. Seizures were selected during the chronic epilepsy phase of this model and classified by behavioral severity according to the Racine scale. Seizures with Racine scale 5&6 were considered generalized and severe. HFOs were marked in 24 seizures during a preictal, ictal, and postictal EEG segment. The duration covered by the HFO during these different segments was analyzed and compared between mild and severe seizures. HFOs were significantly increased during ictal periods (p < 0.001) and significantly decreased during postictal periods (p < 0.03) compared to the ictal segment. Ictal ripples (p = 0.04) as well as fast ripples (p = 0.02) were significantly higher in severe seizures compared to mild seizures. The present study demonstrates that ictal HFO occurrence mirrors seizure severity in a chronic focal epilepsy model in rats. This is similar to recent observations in patients with refractory mesio-temporal lobe epilepsy. Moreover, postictal HFO decrease might reflect postictal inhibition of epileptic activity. Overall results provide additional evidence that HFOs can be used as biomarkers for measuring seizure severity in epilepsy.

scholarly journals Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice

2021 ◽  
Author(s):  
Christos Panagiotis Lisgaras ◽  
Helen E. Scharfman
Keyword(s):  
Kainic Acid ◽  
Temporal Lobe ◽  
High Frequency ◽  
Low Voltage ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe ◽  
Convulsive Seizures ◽  
Almost All ◽  
Video Eeg ◽  
Variable Progression

Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this ambiguity, we slightly modified previous methods and employed continuous wideband video-EEG monitoring from 4 recording sites to best detect and characterize chronic epilepsy outcomes in both male and female mice. We found many more convulsive seizures than most studies have reported. Mortality was low. Analysis of convulsive seizures at 2-4 and 10-12 wks post-IHKA showed a robust frequency (2-4 per day on average) and duration (typically 20-30 sec) at each time. Comparison of the two timepoints showed that seizure burden became more severe in approximately 50% of the animals. We show that almost all convulsive seizures could be characterized as either low-voltage fast or hypersynchronous onset seizures, which has not been reported in a mouse model of epilepsy and is important because these seizure types are found in humans. In addition, we report that high frequency oscillations (>250 Hz) occur, resembling findings from IHKA in rats and TLE patients. Pathology in the hippocampus at the site of IHKA injection was similar to mesial temporal lobe sclerosis and reduced contralaterally. In summary, our methods produce a model of TLE in mice with robust convulsive seizures, and there is variable progression. HFOs are robust also, and seizures have onset patterns and pathology like human TLE.

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