scholarly journals Role of ictal baseline shifts and ictal high-frequency oscillations in stereo-electroencephalography analysis of mesial temporal lobe seizures

Epilepsia ◽  
2014 ◽  
Vol 55 (5) ◽  
pp. 690-698 ◽  
Author(s):  
Shasha Wu ◽  
Hari Prasad Kunhi Veedu ◽  
Samden D. Lhatoo ◽  
Mohamad Z. Koubeissi ◽  
Jonathan P. Miller ◽  
...  
Keyword(s):  
Temporal Lobe ◽  
High Frequency ◽  
High Frequency Oscillations ◽  
Temporal Lobe Seizures ◽  
Mesial Temporal Lobe

scholarly journals Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy

Epilepsia ◽  
2015 ◽  
Vol 57 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Shennan Aibel Weiss ◽  
Catalina Alvarado-Rojas ◽  
Anatol Bragin ◽  
Eric Behnke ◽  
Tony Fields ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Local Field ◽  
Unit Activity ◽  
High Frequency ◽  
Local Field Potentials ◽  
Mesial Temporal Lobe Epilepsy ◽  
Field Potentials ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy

2019 ◽  
Vol 130 (7) ◽  
pp. 1151-1159 ◽  
Author(s):  
Pavel Řehulka ◽  
Jan Cimbálník ◽  
Martin Pail ◽  
Jan Chrastina ◽  
Markéta Hermanová ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe

scholarly journals Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice

2021 ◽  
Author(s):  
Christos Panagiotis Lisgaras ◽  
Helen E. Scharfman
Keyword(s):  
Kainic Acid ◽  
Temporal Lobe ◽  
High Frequency ◽  
Low Voltage ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe ◽  
Convulsive Seizures ◽  
Almost All ◽  
Video Eeg ◽  
Variable Progression

Intrahippocampal kainic acid (IHKA) has been widely implemented to simulate temporal lobe epilepsy (TLE), but evidence of robust seizures is usually limited. To resolve this ambiguity, we slightly modified previous methods and employed continuous wideband video-EEG monitoring from 4 recording sites to best detect and characterize chronic epilepsy outcomes in both male and female mice. We found many more convulsive seizures than most studies have reported. Mortality was low. Analysis of convulsive seizures at 2-4 and 10-12 wks post-IHKA showed a robust frequency (2-4 per day on average) and duration (typically 20-30 sec) at each time. Comparison of the two timepoints showed that seizure burden became more severe in approximately 50% of the animals. We show that almost all convulsive seizures could be characterized as either low-voltage fast or hypersynchronous onset seizures, which has not been reported in a mouse model of epilepsy and is important because these seizure types are found in humans. In addition, we report that high frequency oscillations (>250 Hz) occur, resembling findings from IHKA in rats and TLE patients. Pathology in the hippocampus at the site of IHKA injection was similar to mesial temporal lobe sclerosis and reduced contralaterally. In summary, our methods produce a model of TLE in mice with robust convulsive seizures, and there is variable progression. HFOs are robust also, and seizures have onset patterns and pathology like human TLE.

scholarly journals Early Ictal Recruitment of Midline Thalamus in Mesial Temporal Lobe Epilepsy

2019 ◽  
Author(s):  
Andrew Romeo ◽  
Alexandra T. Issa Roach ◽  
Emilia Toth ◽  
G. Chaitanya ◽  
Adeel Ilyas ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Evoked Potentials ◽  
Temporal Lobe ◽  
Opposite Direction ◽  
Mesial Temporal Lobe Epilepsy ◽  
Midline Thalamus ◽  
Temporal Lobe Seizures ◽  
Mesial Temporal Lobe ◽  
Stimulation Of

AbstractThe causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0-13 seconds) and early propagation (9-60 seconds). Stimulation of either thalamus or hippocampus induced similar habitual seizures. Seizure-induced in the hippocampus rapidly recruited the thalamus. Evoked potentials demonstrated stronger connectivity from the hippocampus to the thalamus than in the opposite direction. The midline thalamus can be within the seizure initiation and symptomatogenic circuits.

Role of the Frontal Lobes in the Propagation of Mesial Temporal Lobe Seizures

Epilepsia ◽  
1991 ◽  
Vol 32 (6) ◽  
pp. 822-837 ◽  
Author(s):  
Jeffrey P. Lieb ◽  
Richard M. Dasheiff ◽  
Jerome Engel ◽  
(P. Genton ◽  
(P. Genton
Keyword(s):  
Temporal Lobe ◽  
Frontal Lobes ◽  
Temporal Lobe Seizures ◽  
Mesial Temporal Lobe

High-frequency oscillations and mesial temporal lobe epilepsy

2018 ◽  
Vol 667 ◽  
pp. 66-74 ◽  
Author(s):  
Maxime Lévesque ◽  
Zahra Shiri ◽  
Li-Yuan Chen ◽  
Massimo Avoli
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
High Frequency ◽  
Mesial Temporal Lobe Epilepsy ◽  
High Frequency Oscillations ◽  
Mesial Temporal Lobe
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