This chapter distinguishes between mere self-regarding reasons to treat oneself in particular ways, and more robust moral duties owed to oneself. While the former are a philosophical commonplace, the latter are absent from most contemporary accounts and their addition to our practical philosophy would be significant. Duties owed to the self are second-personal, in the sense of being directed at a specific person. When a person has a duty to herself, her reasons are particularly strict, they pre-empt other reasons, they require a special sort of acknowledgment of their moral quality, and they engage special moral emotions. As such, if a person accepts that she owes duties to herself, it will impact the way in which she treats herself, and the way she relates to herself, beyond the mere acknowledgment that she has self-regarding reasons.