Methylation of 23S rRNA G748 and the Ribosomal Protein L22 Lys-94 are Critical Factors for maintaining the Association between Ribosome Stalling and Proteome Composition in Streptococcus pneumoniae

In S. pneumoniae, the combination of methylation status of G748 and the residue at position 94 in L22 are essential for both the distribution of ribosome stalling and the binding of TEL to ribosomes.

Ribosome Profiling in Streptococcus pneumoniae Reveals the Role of Methylation of 23S rRNA Nucleotide G748 on Ribosome Stalling

Results support the role of NPET on ribosome stalling. NPET structure is required to realize the species-specific and evolutionary conserved ribosome stalling. These findings clarify the role of NPET structure on the translation process.

The Earthworm Eudrilus Eugeniae: a Model Organism for Regenerative Biology

The earthworm, Eudrilus eugeniae is an economical model system for cell and molecular biological experiments to study regeneration and stem cell biology. The purpose of this brief review is to summarize those published studies on the regeneration biology using E. eugenia and to provide the advantages of the model system.

Recurrent Pregnancy Loss: Proposal for a Novel Diagnostic Protocol with New Molecular Genetics Insight

Although RPL remains unexplained in about 50% of the cases, gynecological, endocrinological, immuno-hematological and genetical factors have been described.

IL6-174G/C (rs1800795) Polymorphism Rather than IL6R (rs2228145 and rs4845618 Polymorphisms is Associated with susceptibility to Rheumatoid Arthritis in the Belarusian Population

Thus, we provide evidence for association of the non-synonymous variant IL6 −174G / C (rs1800795) with risk of RA in the Belarusian population, some features of interplay being revealed between gene polymorphisms analyzed and both gender of patients and RA antibody status.

Progressive Microcephaly, Spasticity and Development Delay: Novel SLC1A4 Variants in Two Portuguese Families and Literature Review

Our results support the deleterious role of SLC1A4 variants and highlight the need of considering this entity, regardless of ethnicity, in pediatric patients presenting with unexplained neurodevelopmental delay and progressive microcephaly, associated or not with spastic tetraplegia or early onset epileptic encephalopathy.