A review of Keith Lehrer’s work over more than half a century suggested a system that motivated the present manuscript. He has written about knowledge, autonomy, self-trust, and consciousness. Many books and volumes of journals have collected deeply insightful articles about his work, including Bogdan (1980); Bender (1989); Brandl, Gombocz, and Pillar (1991); Olsson (2003); and Fürst and Melchior (2012). This posed the question of how it could all fit together into one system. Science, art, and practice challenge us to evaluate and reconsider what we desire, what we believe, and how we represent the world, ourselves in the world, and the world in ourselves. We must make ourselves worthy of our trust and the trust of others in our defensible and autonomous quest for truth and evidence. We embody that defensible system of truth, evidence, theory, meaning, and science. The book is the articulation of the Lehrer’s system.