Chapter 1 sets out the institutional history of the Levant Company in London and Aleppo. It argues that the infrastructures developed from the late sixteenth century to facilitate trade – the legal protection provided by the capitulations, regular shipping routes, systems of postal communication – laid the foundations for a ‘literarum commercium’, a commerce of letters, that would have implications beyond the immediate mercantile concerns of the Levant Company. New opportunities for scholarly inquiry were augmented by the growth of the English community, or ‘factory’, in Aleppo, and, in particular, by the appointment, from the early seventeenth century, of a line of clergymen employed to minister to the expatriate merchants and consular staff. Drawing on the Levant Company archive, the chapter paints a detailed picture of this small outpost, positioning it alongside the more established Venetian and French (and later Dutch) communities and the various Roman Catholic missions then stationed in Aleppo. The chaplains came to serve as the crucial link between Syria, London, and the English universities (predominantly Oxford), with whose members many of them remained in touch from abroad. The chapter also provides an overview of intellectual developments which sets the scene for the more detailed investigations of individual projects explored in the remainder of the book.