In this chapter, Jeff Sebo and L.A. Paul investigate the phenomenon of experiences that transform the experiencer, either epistemically, personally, or both. The possibility of such experiences, Sebo and Paul argue, frequently complicates the practice of rational decision-making. First, in transformative cases in which your own experience is a relevant part of the outcome to be evaluated, one cannot make well-evidenced predictions of the value of the outcome at the time of decision. Second, in cases in which one foresees that one’s preferences would change following the decision, there are issues about whether rational decision-making should be based only on one’s ex ante preferences, or should also incorporate some element of deference to foreseen future preferences. While these issues arise quite generally, Paul and Sebo suggest that they are especially pressing in the context of effective altruism.