Synthesis of a Cinnamic Acid Derivative and Bioactivity as an Anticancer Based on Result Quantitative Structure Activity Relationship (QSAR) Analysis

Synthesis of compound (E)-4-(3-oxo-3-(phenethylamino)prop-1-en-1-il)-1,2-phenylene diacetate (3) analogue (E)-3-(3,4-dihydroxyphenyl)-N-phenethylacrylamide as a recommendation from the QSAR analysis was carried out. The synthesis of these compounds uses the starting material of caffeic acid through the stages of the reaction of acetylation, chlorination, and amidation. Acetylation was carried out using acetic anhydride in pyridine at room temperature for 4 hours. Chlorination was carried out using thionyl chloride reagent in dimethylphromamide solvent under reflux conditions at 80ºC for 4 hours, followed by amidation using phenethylamine in dichloromethane solvent at room temperature for 1 hour. The structure of each phase of the reaction product is identified using FT-IR spectroscopy. Acetylation produces white crystalline solids with melting point 182-184oC, and amidation produces compound 3 in the form of white crystals with melting point 170-173oC. The results of activity tests on murine leukaemia P-388 cells showed that the activity of compound 3 was classified as very strong (IC50 = 0,5 µg /mL) so that it was potentially used as an anticancer drug.

Absorption of Heavy Metal Lead (Pb) by Water Hyacinth (Eichhornia crassipes) and Its Influence to Total Dissolved Solids of Groundwater in Phytoremediation

Waste of heavy metal lead (Pb) in waters needs to be addressed through phytoremediation because it is toxic to the environment. The purpose of this study is to determine the effect of water hyacinth (Eichhornia crassipes) ability in water to absorb heavy metal Pb and its effects to total dissolved solids (TDS) of groundwater during the phytoremediation process. Using E. crassipes, groundwater samples and Pb(NO3)2 as a source of Pb, the initial characterization of the two samples was previously carried out. Created four treatments of ground water, i.e.: P1 contains 2 ppm Pb with E. crassipes, P2 contains 4 ppm Pb with E. crassipes, P3 contains 2 ppm Pb without E. crassipes, and P4 contains 4 ppm Pb without E. crassipes. Observation of Pb by method of atomic absorption spectrometry (AAS) and determination of TDS by gravimetric method, each carried out on days 0, 4, 8, and 12. The results show the treatment of 2 ppm Pb, E. crassipes is more effective at absorbing Pb which is 96.0% compared to treatment 4 ppm Pb which is 90.0%. While 2 ppm Pb and 4 ppm Pb as control only 18.5% and 17.5%. Treatment of 2 ppm Pb which uses E. crassipes shows better water quality than concentration TDS 62.55 ppm compared to treatment of 4 ppm Pb with TDS 70.50 ppm while 2 ppm Pb and 4 ppm Pb as a control does not significantly affect to water quality.

Impact of Cyclone on Livelihood Pattern in the South Western Coastal Region of Bangladesh: Pirojpur

This research was carried out to assess the impact of cyclone on livelihood pattern in Pirojpur district, Bangladesh during January to June, 2017. The study was both qualitative and quantitative type. The primary data were collected using randomly sampling method (42+42+42=126 respondents) from Tushkhali, Bhitabaria and Pattashi villages of Pirojpur district. The secondary data were collected from different journals, articles, books, official documents, thesis papers and also daily newspapers etc. From the study it was observed that monthly income of middle (4001-8000 tk) and high (8001-above tk) income groups ware decreased by 5% and 0.92% respectively while low income people (1-4000 tk) was increased due to decrease of production after Sidr. On the other hand, expenditure ability of low and middle income groups was decreased. Sidr has created a great impact on human health, livestock, fisheries, food habit, crop production and occupation pattern of the affected people. Respondent’s houses were damaged partially (66.78%), 33.22% completely and cultivated land 28.57 % completely by Sidr in study area. Respondents of the study area said that the production of rice (8%), chili (12%), and vegetables (11%) were reduced due to saline water entrance into the crop field after Sidr. Affected people were migrated (temporary 23.10%, local 25% and internal 26.10%) from Pirojpur to Dhaka (53%), Pirojpur to other places (47%) on the post Sidr due to loss of houses, shelters, cultivated land and lack of job opportunity. Among all factors of temporary migration, water logging was the first reason of migrating people of the study area.

Source of Cadmium (Cd) In Soils and Its Transfer to Rice and Vegetables: Karotia Union, Tangail

Cadmium is a trace element which is not essential for human being. High cadmium concentration in some rice samples in Bangladesh was reported than that of other countries. This study was carried out to find out the Cd concentration fertilizers, soils, rice and vegetables and along with other chemical properties of Karotia union, Tangail sadar upazila, Tangail. A total of 29 samples were collected among the 14 soils from 7 stations at 0-15 cm and 16-30 cm depth respectively, 5 vegetables, 5 rice and also 4 different countries TSP fertilizers from local market. The Cd concentration values of all soil samples were found between 0.97 to 1.73 mg/kg (0-15 cm) and 0.53 to 0.83 mg/kg (16-30 cm), respectively and the vegetable sample values were found between 0.053 mg/kg to 0.123 mg/kg (d.w.).The rice sample values were found between 0.05 mg/kg to 0.096 mg/kg (d.w.). The fertilizer sample values were found between 20.67 to 92.33 mg/kg. The soil pH values obtained 7.06 to 7.70 (0-15 cm) and 7.48 to 7.88 (16-30 cm) which indicated that the study area soils were neutral to moderately alkaline. The EC values of all soil samples were between 47.67 to 82.67dSm-1 (0-15cm) and 33.33 to 58.33dSm-1 (16-30 cm). The organic matter content of all soils ranged from 0.789 to 0.905% and 0.351 to 0.869% at (0-15 cm and 16-30 cm), respectively. The available sodium (Na) values of soils were found between 1.84 to 1.92 ppm (0-15 cm) and 1.83 to 1.90 ppm (16-30 cm), respectively. The available potassium values ranged from 1.81 to 1.96 ppm (0-15 cm) and 1.84 to 1.97 ppm (16-30cm), respectively. The available calcium values of all soil samples were 1.92 to 1.97 ppm (0-15 cm) and 1.91 to 1.96 ppm (16-30 cm), respectively.

The Bio-Adsorption Pattern Bacteria Symbiont Sponge Marine Against Contaminants Chromium and Manganese In The Waste Modification of Laboratory Scale

The use of sponge symbionts bacteria as marine biomaterials in the heavy metal bio-adsorption method is an effort to save the marine environment from contamination of heavy metal contaminants. The ocean is a giant container, most vulnerable to contamination of pollutants. The target of the research is to determine the potential, capacity and pattern of bio-adsorption of sponge symbionts bacteria against various pollutants so that the toxic properties of heavy metal contaminants can be minimize. The method used is to interact with the bacterial suspension on the test metal concentrations that have been determined. The parameters measured were optical density, pH and concentration of heavy metals after the interaction lasted several days and the calculation of capacity, efficiency and bio-adsorption patterns of bacterial isolates from sponges. Results: The pattern and bio-adsorption power of AC bacteria to Cr and Mn ions were higher than AC bacteria, the adaptability of AC and BS bacteria was stronger in Cr (III) contaminated media compared to Cr (VI) toxic media, causing bacterial cell population BS and AC in Cr (III) and Mn (II) media are more abundant than in Cr (VI) and Mn (VII) media, capacity and bio-adsorption efficiency of BS and AC bacteria agains Cr (III) ˃ Cr (VI) ions and Mn (II) ˃ Mn (VII), It is suspected that there is an influence of reactivity and toxic properties of the metal ion test on the performance of the sponge symbionts in bio-adsorption

Synthesis Of Glycerol Carbonate From Glycerol And Urea Using Limestone As Catalyst Source

Synthesis of Glycerol carbonate from glycerol and urea using limestone as a catalyst has been conducted. This study aims to make glycerol carbonate from glycerol and urea by utilizing scattered natural limestone widespread in Southeast Sulawesi as a catalyst source. The catalyst was obtained from the calcination of natural limestone to decompose CaCO3 to CaO. This condition added to glycerol and urea to test the catalyst activity. Synthesis of glycerol carbonate was carried out through the carbamoylation reaction of glycerol with urea. The advantage of this method is the reaction carried out with free solvents and running in ambient pressure (1 atm). The stages of catalyst testing in the reaction of glycerol carbonate formation were carried out by reacting glycerol, urea, and calcined limestone with 1: 1 substrate mole ratio with a catalyst concentration of 5% mass over glycerol. Characterization used was Fourier Transform Infrared Spectroscopy (FTIR) and supported by Gas Chromatography (GC) data. Optimization catalysis reaction was obtained at a temperature of 140oC for 4 hours and using a catalyst mole ratio to 5% substrate

Effect Of The Contact Time Of Candlenut Shell Charcoal And H3PO4 Activator As On The Purification Process Of Used Cooking Oil

Research on Comparison of the Contact Time of Candlenut Charcoal with H3PO4 Activator in the Process of Purifying Used Cooking Oil has been conducted. The purpose of this study was to determine the ability of candlenut shells activated with H3PO4 against purifying used cooking oil. The variation of the number of candlenut shells used is 1 gram, 2 grams, and 3 grams and the variation of contact time is 10 minutes, 30 minutes and 60 minutes. The results showed that the activation of hazelnut shell using H3PO4 fulfills SNI 16-3730-1995, while the results of used cooking oil purification with 2 grams of activated charcoal in 60 minutes resulted in a decrease in peroxide number of 64.58% and free fatty acids of 54, 84%.

α-Glucosidase Inhibitory Activity Of Cucurbitane Derivate Isolated From Methanol Extract Of Momordica charantia L. Leaves

Cucurbitane derivative has been isolated from methanol extract of the leaves of bitter melon (Momordica charantia). Purification of methanol extract using vacuum column chromatography method using n-hexane: ethyl acetate as the mobile phase was obtained a white powder isolate. This isolate was elucidated to obtain chemical structures based on spectroscopic data (FT-NMR, FT-IR, and LC-MS/MS) and resulted a cucurbitane derivate, namely momordicine I. The MeOH extract and the isolate were evaluated for α-glucosidase inhibitory effect. Both MeOH extract and momordicine I showed moderate activities with %inhibition 27.34% and 15.79 % at 100 µg/mL repectively.

Extraction Cellulose From Rice Husk

Cellulose from rice husk has been successfully synthesized. Rice husk is an abundant agricultural waste and has a high cellulose content. Bioconversion of rice husk into cellulose begins with the stages of delignification and bleaching. The resulting cellulose was characterized using FTIR and XRD. The IR spectra show a strong absorption peak at 3444.87 cm− 1 which is associated with stretching vibrations O − H (hydrogen bonds between molecules), absorption peaks at 1033.85 cm− 1 are identified as stretching C − O − C which is β bond −1,4 glycosidic from cellulose. XRD shows the particle size of cellulose which is 3.44 nm and has crystallinity of 58.73%. These results indicate that cellulose from rice husk has good characteristics. Keywords: Rice Husk, Cellulose, FTIR, XRD

Phytocimia Test And Antibacterial Bioactivity Of Extracts from Stem Bark of Artocarpus integer (Thunb.) Merr

This research aims to identify the compound group and determine the antibacterial activity of n-hexane, chloroform, and methanol fractions of Artocarpus integer (Thunb.) Merr stem bark. All fractions contain groups of terpenoid and steroid compounds. Antibacterial activity was detemined using agar diffusion method with MHA (Muller Hinton Agar) media on Escherichia coli (gram negative) and Staphylococcus aureus (gram positive). Ciprofloxacin was used as a positive control and methanol as a negative control. The three fractions were able to inhibit the growth of Escherichia coli and Staphylococcus aureus. The chloroform fraction showed the highest activity after 48 hours incubation with inhibition zones of 10.8 and 10.4 mm respectively.