This chapter examines the role of synechism in Charles S. Pierce's pragmatism. Pierce frequently remarked that his pragmaticism was intimately related to synechism or the doctrine of continuity. Indeed, Peirce’spent the better part of twenty years working out his synechistic cosmology. According to him, synechism as a logical principle forbids one to consider any inexplicability as a possible explanation, and this is nothing more or less than the assumption behind the scientific enterprise as such, namely, that the world is knowable. The synechistic principle does not deny that there is an element of the inexplicable and of the ultimate and brute in the world. This does not, however, block the road of inquiry, but rather stimulates one to generalize from the experience, to form new hypotheses, because one is convinced that the facts can be understood—that they manifest another mode of being other than brutishness, namely, obedience to rationality and to law.