This chapter describes the fictional forms by which Laurence Sterne’s Tristram Shandy and A Sentimental Journey present confrontations between characters separated by differences of ethnicity, race, and species, particularly in episodes that were frequently republished in popular anthologies. Around the turn of the nineteenth century, readers encountered a version of Sterne’s sentimental fiction that is incompatible with a critical consensus about his novels. While Sterne has been understood to base subject-formation on the appropriation of another’s sentiments through the experience of sympathy, popular anthologized forms of his works, by contrast, emphasize emotional disturbance and preclude the return to a stable, narrating self. Anthologized versions of Sterne mobilize aspects of his original works—the structure of the frame tale, an interest in giving voice to figures of radical difference (including animals and former slaves), and the experience of shared affect and narrative—and specify Romantic-era fiction’s revision of sympathy.