Background: Lymphomatoid papulosis is a rare CD30+ lymphoproliferative T-cell disorder with limited effective treatments. Objective: We describe the case of a 50-year-old woman diagnosed with lymphomatoid papulosis who was unable to access phototherapy and who failed to clear while on systemic treatment with methotrexate. Methods: The patient was initiated on mycophenolate mofetil (MMF), a prodrug of mycophenolic acid, at a dose of 2 g divided twice daily. Results: MMF produced a rapid response with complete clearing within 8 weeks, and the patient has been successfully maintained for 2 years at the same dose with no noted side effects. Other patients in our clinic have had similar success. Conclusions: Mycophenolic acid is a safe and well-tolerated therapy for lymphomatoid papulosis.
A 48-year-old Thai female, who had stage 2 carcinoma of the breast presented with recalcitrant erythrodermic psoriasis which was unresponsive to conventional therapies. She was prescribed 6 mg/kg day cyclosporin A. The erythroderma responded rapidly and was completely cleared within 3 weeks. The dosage was reduced in a step-wise manner to 4 and then 2 mg/kg day and was stopped after 2 months of treatment. Complete clearing of the skin lesion was observed without any side-effects except mild nausea. The patient was then referred to surgery for mastectomy and chemotherapy. There was no clinical relapse during more than 1 year of follow-up and at present she is continuing to do well.
The need for follow-up roentgenograms documenting complete clearing of pulmonary infiltrates in the pediatric patient with acute pneumonia was studied prospectively. Seventy of 129 children enrolled in the study had a repeat roentgenogram within three to four weeks after initial diagnosis. Twenty percent of this group had residual pulmonary infiltrates. Of the two thirds of those who returned for a second follow-up roentgenogram, the infiltrates had cleared completely within three months. Routine repeat chest roentgenograms may not be necessary unless there is clinical evidence of persistent respiratory difficulty or failure to thrive.
Thinning or complete clearing of dense mulga (Acacia aneura) woodlands in south western Queensland may lead to undesirable rangeland conditions unless sound property management is practised. Even ten years after thinning, ground storey vegetation in an ungrazed situation is still in a state of flux. Livestock management following clearing can markedly influence pasture composition and mulga regeneration. Poor rangeland management may lead to reductions in pasture basal area sufficient to reduce productivity and accelerate degeneration through soil and nutrient losses in run-off waters.
Recently many articles have appeared in Pediatrics1-3 and in the literature4 relating the toxic effects of diiodohydroxyquin (Diodoquin) on the eye. In many instances the medication had been used for the treatment of acrodermatitis enteropathica.3-5
Following the report by Moynahan6 of successful treatment of this condition with the oral administration of zinc sulfate, we treated a 7-year-old boy suffering from acrodermatitis enteropathica with 50 mg of zinc sulfate by mouth, three times daily. The effect of this regimen was dramatic with complete clearing of all the skin lesions, regrowth of normal hair, and arrest of the diarrhea.
Both complete clearing and thinning of invasive trees lead to short-term recovery of native riparian vegetation in the Western Cape, South Africa