Field experiments were conducted to determine the effects of tank-mix and sequential postemergence (POE) applications of the insecticides carbaryl and dimethoate with sethoxydim on large crabgrass control and cotton tolerance. Large crabgrass control was similar with sethoxydim and sethoxydim-dimethoate tank mixtures. Although tank mixing carbaryl with sethoxydim reduced control, it was not reduced when carbaryl was applied 2 days before or 2 days after applying sethoxydim. Neither the insecticides nor sethoxydim applied alone or as tank mixtures injured cotton or affected lint yield, percent lint, fiber length, fiber length uniformity, fiber strength, or micronaire.