The accuracy and safety of CT-guided iodine-125 seed implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma

Purpose To investigate the accuracy, dosimetric parameters, and safety of 3D-printing non-coplanar template (3D-PNCT)-assisted CT guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas Methods and materials We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needle insertion position, angular, and the needle tip distance deviations of preoperative plan with that of intraoperative in brachytherapy treatment planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intraoperative real-time plan, and postoperative plan, including D90, D100 (the dose to 90% and 100% of the target volume), V100, V150, and V200 (the volume receives 100%, 150%, and 200% of the prescribed doses). The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), and homogeneity index (HI) of the targets were compared among preoperative plan, intraoperative real-time plan, and postoperative plan. The perioperation complications and RSI-BT-related toxicity were assessed. Results The median follow-up was 8.2 months (range 1–18.5 months). One patient was lost to follow-up after RSI-BT. Fourteen patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0–30). The mean angular deviation was 2.70 ± 3.00° (range, 0–20). The needle tip distance deviation was 6.90 ± 6.00 mm (range, − 30–28). D90 for preoperative plan, intraoperative plan, and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04, and 128.98 ± 22.75, respectively. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p = 0.036). Four lesions reached CR, six lesions reached PR, three lesions were SD, and three lesions were PD. Four patients with moderate pain became mild, and two with mild pain relieved completely after RSI-BT. The other parameters showed no differences among preoperative plan, intraoperative plan, and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side effects were observed. Conclusion CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate, and feasible strategy for recurrent carcinomas located in the retroperitoneal regions.

The accuracy and safety of CT-guided iodine-125 seeds implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma.

Purpose: To investigate the accuracy, dosimetric parameters and safety of 3D-printing non co-planar template (3D-PNCT) assisted CT-guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas.Methods and materials: We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needles insertion position, angular and the needle tips distance deviations of preoperative plan with that of intra-operative in brachytherapy treatment-planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intra-operative real-time plan and postoperative plan, including D90, D100 (the dose to 90% and 100% of the target volume), V100, V150 and V200 (the volume receives 100%, 150% and 200% of the prescribed doses). The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), homogeneity index (HI) of the targets were compared among preoperative plan, intra-operative real-time plan and postoperative plan. The peri-operation complications and RSI-BT related toxicity were assessed.Results: The median follow-up was 8.2 months (range 1-18.5months). One patient lost follow-up after RSI-BT. 14 patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0-30). The mean angular deviation was 2.70 ± 3.00 degrees (range, 0-20). The needles tip distances deviation was 6.90 ± 6.00 mm (range, -30-28). D90 for preoperative plan, intra-operative plan and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04,128.98 ± 22.75. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p=0.036). Four lesions reached CR, six lesions reached PR, three lesions were SD and three lesions was PD. Four patients with moderate pain became mild, two with mild pain relived completely after RSI-BT. The others parameters showed no differences among preoperative plan, intraoperative plan and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side-effects were observed.Conclusion: CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate and feasible strategy for recurrent carcinomas located in retroperitoneal regions.

Machine Learning Algorithm Based Bandwidth Prediction for Internet Usage

The applicability of framework structure and affiliation arranging recognize a basic activity in the bandwidth prediction. The procedure for predicting the framework use is to see the basic transmission limit with respect to future periods. This prediction helps with utilizing the techniques workplaces in the saint way. Thinking about the fundamental cost of bandwidth, at top hours of a framework traffic we can follow an amazing sort of plan to purchase. In this paper, the past use data of FWDR organize centers is at risk to univariate direct time plan ARIMA model after precise change is used to calculate necessary bandwidth limit concerning future needs. The anticipated data is veered from the obvious data gained from a for all intents and purposes indistinguishable framework and the foreseen data has been viewed as inside ten percent MAPE. This design reduction the MAPE by eleven point seventy-one percentage and fifteen point forty-two percent of self-rulingly when stood separated from the non-able changed ARIMA model at ninety-nine percent CI. The outcome show that the suitably changed ARIMA design has improved show when meandered from non-intentionally changed ARIMA model. Increasingly significant dataset can be passed on with season alterations and thought of expanded length groupings, for dynamically unequivocal and longer term needs.

The accuracy and safety of CT-guided iodine-125 seeds implantation assisted by 3D non-coplanar template for retroperitoneal recurrent carcinoma.

Purpose To investigate the accuracy, dosimetric parameters and safety of 3D-printing non co-planar template (3D-PNCT) assisted CT-guidance for radioactive iodine-125 (125I) seed implantation brachytherapy (RSI-BT) for retroperitoneal recurrent carcinomas. Methods and materials: We enrolled 15 patients with 17 retroperitoneal recurrent carcinomas after external beam radiotherapy (EBRT). All patients received CT-guided 125I RSI-BT assisted by 3D-PNCT successfully. We compared the original needles insertion position, angular and the needle tips distance deviations of preoperative plan with that of intra-operative in brachytherapy treatment-planning system (B-TPS). The dosimetric parameters of RSI-BT were evaluated on preoperative plan, intra-operative real-time plan and postoperative plan, including D90, D100, V100, V150 and V200. The quality assurance of RSI-BT evaluated on conformal index (CI), external index (EI), homogeneity index (HI) of the targets were compared among preoperative plan, intra-operative real-time plan and postoperative plan. The peri-operation complications and re-radiation related toxicity were assessed. Results The median follow-up was 8.2 months (range 1-18.5months). One patient lost follow-up after RSI-BT. 14 patients were assessed for response rate and toxicity. The mean entrance point distance deviation for all 165 needles was 4.50 ± 4.10 mm (range, 0–30). The mean angular deviation was 2.70 ± 3.00 degrees (range, 0–20). The needles tip distances deviation was 6.90 ± 6.00 mm (range, -30-28). D90 for preoperative plan, intra-operative plan and postoperative plan were 140.55 ± 23.93, 124.25 ± 28.04,128.98 ± 22.75. There was significant difference between D90 of preoperative plan with that of intraoperative plan (p = 0.036). Four patients reached CR, three patients reached PR, three patients were SD and three patients was PD. Four patients with middle pain became moderate, two with moderate pain relived completely after RSI-BT. The others parameters showed no differences among preoperative plan, intraoperative plan and postoperative plan. The perioperative complications were observed in four patients, including three patients of grade 1 and one patient of grade 2. No ≥ grade 3 side-effects were observed. Conclusion CT-guided 125I RSI-BT assisted by 3D-PNCT was a safe, accurate and feasible strategy for recurrent carcinomas located in retroperitoneal regions.

A Novel Technology in Lean Manufacturing

In today’s emerging world, as the demands and expectations of the people grow higher and higher every day, so is the competition. Thus to face the demand and to be competitive & survive in the market, industries have to produce superior quality components without producing waste. This leads every manufacturer to optimize and standardize the processes of every component being produced. One such concept employed is ―Lean Manufacturing‖. In this paper a novel tool in lean manufacturing is applied. The processes are continuously monitored and collected necessary data to generate VSM and declare the CSM based on the available data. Then the takt time graph and the balanced time – Cycle time – Downtime graph were plotted with the help of which, the scopes for improvements are identified and then the targets are obtained. The FSM is also drawn and a time plan for projects is prepared and monitored continuously. Based on the type of process and the project, different tools are adopted to reduce the cycle time, downtime, waste and thereby increase the productivity. By implementing newer tools, the future demand of the process was successfully proved to be met by the existing line itself and the need of an additional line was defeated, thereby making monetary savings. By implementing this system, the productivity can be constantly increased.

BESIDES ACTIVE AGING? A TRANQUIL LIFE AFTER RETIREMENT

This research explores how people think of the time plan after their retirement in rural area in Taiwan. fifty-nine participants in rural communities were interviewed. The findings show patterns of a tranquil life after retirement in three aspects which represent the philosophy mixing in Taiwan (Taoism, Buddhism, and Confucianism). 1). Taking things as they are and following the mandate of heaven(Taoism). 2). the retirement life will not be affected by social changes, and feeling that the pace of life in the society has not changed (Buddhism). 3) When talking about “Future aspirations” and “Future ideal life”, they show concern to their children and posterity. (Confucianism). The findings of tranquil life contribute an alternative way of active ageing with considering the culture. The implications of tranquil life are discussed in the design of elderly education program, technology development to enhance social interaction, and culturally motivated ageing and wisdom.

Analisis Model Dua-Tahap Pemrograman Stokastik untuk Persimpangan yang Padat

Masalah transportasi terjadi ketika tingkat arus masuk kendaraan melebihi laju arus keluar kendaraan di satu tempat. Berbagai faktor mendukung terjadinya masalah kemacetan, salah satunya persimpangan yang padat dan mengakibatkan keterlambatan kendaraan sehingga arus masuk tidak sesuai dengan arus keluar. Pengaturan aliran lalu lintas di persimpangan biasanya menggunakan sinyal lampu lalu lintas yang berfungsi untuk menghentikan aliran lalu lintas ke arah tertentu dan memungkinkan arus dari arah lain pergi. Penulis mengusulkan menggunakan pemrograman stokastik dua tahap untuk menghasilkan model baru dalam penjadwalan rencana waktu sinyal yang efisien untuk meminimalkan penundaan kendaraan yang diharapkan. Transportation problems occur when the level of vehicle inflows exceeds the rate of vehicle outflow in one place. Various factors support the occurrence of congestion problems, one of which intersections are dense and result in vehicle delays so the incoming currents aren’t in accordance with the outflow. Traffic flow arrangements at intersections usually use traffic light signals that serve to stop traffic flow in certain directions and allowing currents from other directions to go. The authors propose using two-stage stochastic programming so as to produce new models in scheduling an efficient signal time plan to minimize expected vehicle delays.