CARDIOKIN1: Computational Assessment of Myocardial Metabolic Capability in Healthy Controls and Patients With Valve Diseases

Background: Many heart diseases can develop a reduced pumping capacity of the heart muscle. A mismatch between ATP demand and ATP production of cardiomyocytes is one of the possible causes. Assessment of the relation between the myocardial ATP production (MV ATP ) and cardiac workload is important for better understanding disease development and choice of nutritional or pharmacological treatment strategies. As there is currently no method for the measurement of MV ATP in vivo , the use of physiology-based metabolic models in conjunction with protein abundance data is an attractive approach. Methods: We developed a comprehensive kinetic model of the cardiac energy metabolism (CARDIOKIN1), which recapitulates numerous experimental findings on cardiac metabolism obtained with isolated cardiomyocytes, perfused animal hearts and in vivo studies with humans. We used the model to assess the energy status of the left ventricle (LV) of healthy subjects and patients with aortic stenosis (AS) and mitral valve insufficiency (MI). Maximal enzyme activities were individually scaled by means of protein abundances in LV tissue samples. The energy status of the LV was quantified by the ATP consumption at rest (MV ATP (rest)), at maximal workload (MV ATP (max)), and by the myocardial ATP production reserve (MAPR) representing the span between MV ATP (rest) and MV ATP (max). Results: Compared with controls, in both groups of patients, MV ATP (rest) was increased and MV ATP (max) was decreased resulting in a decreased MAPR, although all patients had preserved ejection fraction. Notably, the variance of the energetic status was high ranging from decreased to normal values. In both patient groups, the energetic status was tightly associated with mechanic energy demand. Moreover, a decrease of MV ATP (max) was associated with a decrease of the cardiac output indicating that cardiac functionality and energetic performance of the ventricle are closely coupled. Conclusions: Our analysis suggests that the ATP producing capacity of the LV of patients with valvular dysfunction is generally diminished and correlates positively with mechanic energy demand and cardiac output. However, large differences exist in the energetic state of the myocardium even in patients with similar clinical or image-based markers of hypertrophy and pump function.

Possibilities of Energy Harvesting from the Suspension System of the Internal Combustion Engine in a Vehicle

The automotive industry faces huge challenge in environmental protection by reducing fossil fuels and energy consumption by developing various practical solutions in energy harvesting. The current analysis is related to the diesel engine power supply system in a passenger off-road vehicle for application of the piezoelectric energy harvesting system. Experimental tests were carried out for the three constant rotational speed values - 800, 1000 and 1500 rpm. The results pertained to operational and simulation tests of available power supply options from the engine suspension system in the vehicle, e.g. to power sensors supervising the engine’s operation or other small electrical devices in the vehicle. The simulations of output voltage were conducted by means of a nonlinear model with a resonator coupled to a piezoelectric elastic beam deformed in the magnetic field to improve the band of frequency transducing kinetic mechanic energy into electric energy.

Mechanochemical synthesis of aromatic sulfonamides.

A three-component Pd-catalysed aminosulfonylation reaction of K2S2O5, amine with aryl bromides or aromatic carboxylic acids is described. This strategy utilises mechanic energy and accommodates primary as well as secondary aliphatic...

Theoretical and Experimental Analysis for Performance of Wind Turbine

This research depends on carrying out an applied and numerical analysis for capability to utilize winds turbines which considered as means of renewable and friendly energy to environment, and how to make use of this technology to generate electric energy in Kirkuk city. Where it was studied shifting kinetic energy of winds into mechanic energy and has been accomplishes install a horizontal-turbine in one of work sites in Kirkuk city of (16m) height of the ground level. It has tri-blades of (400W) power. It has been connected to an electric system supply designed and manufacture during the research period. In order to measure the voltage-difference and electric current consequently to measure the power and energy produced from the wind turbine and changed according to the wind speed alteration. Gauge records for two time seasons are taken by using the technology-programming of delicate controller in simultaneous work with meteorological system, so that it can set data-principle to be analyzed by using (MATLAB) program to find and check theoretical generated power compared with practical results and find the range of validity to generate the sufficient energy for domestic consumption. The results shows that summer season is better than winter season in using wind turbine in Kirkuk city. As the monthly energy rate produce during summer season has emerged to ten-time than monthly energy rate produced during winter season.

Mathematical model for volcanic harmonic tremors

Harmonic tremors consist in the release of infrasonic energy associated with volcanic activity. The typical frequency range of harmonic tremors is 0.1–12 Hz. We suppose that the harmonic tremors are due to the formation of bubbles entrapped in cavities that oscillate converting thermal energy into mechanic energy. Reproducing the natural phenomenon through an experimental apparatus, we propose here a mathematical model to describe the oscillatory mechanism and to detect the frequency as a function of the main physical parameters. We show that the frequency obtained through the model is in agreement with the one obtained through experimental measurements and with the data available from the literature, proving the consistency of the proposed model.

Prebiotic Sugar Formation Under Nonaqueous Conditions and Mechanochemical Acceleration

Monosaccharides represent one of the major building blocks of life. One of the plausible prebiotic synthesis routes is the formose network, which generates sugars from C1 and C2 carbon sources in basic aqueous solution. We report on the feasibility of the formation of monosaccharides under physical forces simulated in a ball mill starting from formaldehyde, glycolaldehyde, DL-glyceraldehyde as prebiotically available substrates using catalytically active, basic minerals. We investigated the influence of the mechanic energy input on our model system using calcium hydroxide in an oscillatory ball mill. We show that the synthesis of monosaccharides is kinetically accelerated under mechanochemical conditions. The resulting sugar mixture contains monosaccharides with straight and branched carbon chains as well as decomposition products. In comparison to the sugar formation in water, the monosaccharides formed under mechanochemical conditions are more stable and selectively synthesized. Our results imply the possibility of a prebiotic monosaccharide origin in geochemical environments scant or devoid of water promoted by mechanochemical forces such as meteorite impacts or lithospheric activity.

Mechanically Activated Chemical Conversion of Gaseous Hydrocarbons

Propane-butane gaseous mixtures were subjected to mechanical treatment in centrifugal ball mill in the absence or presence of some mineral particles. It was found that the composition of gas mixture was changed significantly depending on duration of the mechanical coercion and solid or porous nature of mineral additives. The mechanical treatment of light hydrocarbons in the presence of quartz particles at the temperatures not exceeding 100 °C resulted at long last in complete conversion of initial organic compounds to methane, hydrogen and small amounts of carbon. The same alterations of gas composition were lesser profound when the mechanical treatment was carried out in the absence of minerals or in the presence of porous silica gel or aluminum oxide. It have been shown that direct transformation of mechanic energy to intramolecular energy of hydrocarbons is more responsible for their destruction during the process considered rather than catalytic properties of the minerals. The removal of heavier hydrocarbons from natural or casing-head petroleum gas by means of MA treatment permits to facilitate further gas transportation and to improve essentially its heat-physical properties, namely, to decrease gas average molecular mass and specific gravity and to increase its caloricity and Wobbe number' values.

PENGARUH ELEKTROLISER TERHADAP KEPEKAAN BAHAN BAKAR PADA MESIN DIESEL 1 SILINDER 20 HP

Sutomo, Murni, Senen, Rahmat, Electrolyzer is development of a electrolysis technology to produce HHO gas, or Brown’s gas. Diesel engine use solar (diesel oil) as combustion’s material to produce thermal energy and oxidation and will be changed to mechanic energy. The base product of thermal energy by oxidation diesel oil, is would like to use electrolyzer to produce HHO and insert to the fuel combustion. Because HHO is a reactive gas, so in our research we hopeful will increase the thermal energy in combustion process and decrease the diesel oil consumption. The result of this research is the BSFC (Brake Shat Fuel Consumption) will decrease 2.5% up to 3.2%. Key word: electrolyzer, diesel engine, BSFC