Morphometric justification of osteosynthesis using implants coated with titanium and hafnium nitrides

Aim. To perform comparative and morphological assessment of the reparative processes in the bone and the surrounding soft tissues during intramedullary osteosynthesis using stainless steel implants and titanium nitride coated stainless steel implants.Methods. 40 rabbits who underwent open tibial osteotomy followed by retrograde insertion of the implant into the medullary canal served as an experimental model. 2 mm diameter nails of 12X18H9T steel coated with titanium and hafnium nitrides were used. In the control group, similar nails without coating were used. Histological sections of bone fragments and postoperative wounds, which were taken for morphological study on the 10th, 30th, 60th and 180th day from the beginning of the experiment, were stained with hematoxylin and eosin and with picrofuchsin by Van-Gieson method.Results.The percentage of leukocyte-necrotic masses on the 10th day was 3.5±0.2% in the experimental group and 6.0±0.4% in the comparison group (pConclusion. Osteosynthesis using nails coated with titanium and hafnium nitrides contributes to reduction of the inflammatory response in the surrounding tissues, accelerates the process of reparative regeneration, providing an earlier wound epithelialization and reducing the likelihood of complications development such as incomplete closure of bone defect.

Clinical Study of the Influence of Implants Made of Different Metals on the Physical Status of Experimental Animals

Biocompatibility of implants made of steel 12X18H9T, steel 12X18H9T coated with titanium and hafnium nitrides, and steel 12X18H9T coated with titanium and zirconium nitrides was studied in rats. Implants that represented pins 8-10 mm long and 0.5 mm in diameter were inserted intramedullary into the middle third of the tibia after drilling. The ends of pins were turned down and placed under the skin. The wound was sutured tightly. Dynamics of body weight and temperature as well as the condition of the hair, eyes, oral and nasal mucosa were assessed on days 10, 30, 60 and 90 after implantation. It was shown that implants coated with titanium and hafnium nitrides caused minimum systemic and local reactions while implantation of pins coated with titanium and zirconium nitrides resulted in the development of more pronounced inflammatory changes on both the local and systemic level.

Clinical Study of the Influence of Implants Made of Different Metals on the Physical Status of Experimental Animals

Biocompatibility of implants made of steel 12X18H9T, steel 12X18H9T coated with titanium and hafnium nitrides, and steel 12X18H9T coated with titanium and zirconium nitrides was studied in rats. Implants that represented pins 8-10 mm long and 0.5 mm in diameter were inserted intramedullary into the middle third of the tibia after drilling. The ends of pins were turned down and placed under the skin. The wound was sutured tightly. Dynamics of body weight and temperature as well as the condition of the hair, eyes, oral and nasal mucosa were assessed on days 10, 30, 60 and 90 after implantation. It was shown that implants coated with titanium and hafnium nitrides caused minimum systemic and local reactions while implantation of pins coated with titanium and zirconium nitrides resulted in the development of more pronounced inflammatory changes on both the local and systemic level.