The frequency of HPD gene mutation profile in solid tumors with PD-L1 expression positive.

e15175 Background: Program death-ligand (PD-L1) expression and tumor mutational burden (TMB) are the promising predictive biomarkers in immunotherapy for solid tumors. Immunotherapy could be harmful in patients harboring hyper-progressive disease (HPD) gene mutations. Nevertheless, the distributions of HPD gene mutation profile in patients with PD-L1 positive solid tumors especially in East Asian populations have not been well characterized yet. Methods: In this study, tumor tissues from 354 patients using 539 genes panel based on next generation sequencing were performed. Single nucleotide variants (SNVs) of DNMT3A gene and copy number variants (CNVs) of M DM2, MDM4, C CND1, F GF3, F GF4 and F GF19 genes were evaluated as HPD mutations. The protein expression of PD-L1 was divided into three groups as g1 (TC < 1%), g2 (1% ≤ TC < 50%) and g3 (TC ≥ 50%) via the percentage of positive tumor cells (TC value) identified by immunohistochemistry (IHC) method. The ratios of patients with or without HPD mutations in different PD-L1 expression groups were calculated by χ2 test using program SPSS v22.0. Results: In 354 patients with solid tumors, 33 of 354 (9.3%) were found harboring HPD mutations. The ratios of patients with HPD mutations in three PD-L1 expression groups were 8.6% in g1, 10.4 % in g2 and 8.7% in g3, respectively. Meanwhile, the ratios of patients without HPD related mutations in three PD-L1 expression groups were 91.4%, 89.6 % and 91.3%, respectively. There were no significant differences of HPD frequency between different PD-L1 expression groups via χ2 test (χ2 = 0.323, p = 0.851). Conclusions: The frequency of HPD gene mutations was not significantly heterogeneous between different PD-L1 expression groups and indicated that immunotherapy for patients with PD-L1 expression positive needed to test HPD related gene mutations. Our study provided meaningful information to the precise administration of immunotherapy in cancer clinical practice. As a retrospective study with a relatively small population, the conclusions of this study needed to be verified with a larger sample.

Model Pembinaan Taḥfīẓ Alquran pada Program Santri Taḥfīẓ Alquran Mukim Mahasiswa Tahun 2016 di Pondok Pesantren Daarut Tauhiid Bandung

Tulisan ini merupakan penelitian lapangan yang membahas tentang model pembinaan taḥfīẓ Alquran di Pondok Pesantren Daarut Tauhiid Bandung. Tujuan utama penelitian ini adalah untuk mengetahui dan memperoleh gambaran mengenai model pembinaan taḥfīẓ Alquran yang diterapkan Daarut Tauhiid Bandung dalam mendidik dan mengembangkan santri khususnya santri taḥfīẓ Alquran mukim mahasiswa hingga mampu melahirkan generasi yang ḥafīẓ Alquran. Penelitian ini menggunakan metode deskriptif dengan pendekatan kualitatif. Dalam pengumpulan data menggunakan teknik wawancara, observasi, dan studi dokumentasi serta triangulasi. Sedangkan dalam analisis data menggunakan reduksi data, display data, koding dan penarikan kesimpulan. Berdasarkan hasil penelitian, Program STQ mahasiswa di Daarut Tauhiid Bandung memiliki visi dan misi serta tujuan yang jelas untuk melahirkan generasi ḥafīẓ Alquran yang memiliki ruhiah yang bagus dan akhlak mulia dengan dilandasi nilai-nilai Qurani. Selain itu, pada bagian perencanaan, kurikulum yang digunakan adalah kurikulum yang dirancang sendiri yang mencakup latar belakang program, tujuan program, struktur organisasi, sasaran dan target program, reciutmen program, tahapan kegiatan, metodologi pembelajaran, materi-materi, fasilitas dan mempersiapkan segala sesuatu yang mendukung pembinaan program taḥfīẓ Alquran. Sedangkan dalam pelaksanaannya, kegiatan pembinaan ini menyesuaikan dengan keadaan santri mengingat santri memiliki aktivitas di luar asrama sebagai seorang mahasiswa yang aktif di kampus. Selain itu proses pendidikan Islam tidak hanya didapatkan dari kegiatan belajar mengajar saja, melainkan dari pembiasaan ibadah, kedisiplinan, dan lingkungan Daarut Tauhiid Bandung yang sangat mendukung. Sedangkan evaluasi yang terdapat dalam pembinaan ini di antaranya evaluasi santri, evaluasi aspek kinerja musyrifah dan evaluasi program itu sendiri yang dilaksanakan dengan rutin disetiap jadwal yang telah ditentutkan. Adapun model pembinaan taḥfīẓ Alquran yang diterapkan Daarut Tauhiid Bandung dalam mendidik dan mengembangkan santri taḥfīẓ Alquran mukim mahasiswa adalah model halaqah. Implikasinya, hasil penelitian mengenai model pembinaan taḥfiẓ Alquran ini dapat digunakan sebagai salah satu contoh pada pelaksanaan program taḥfiẓ Alquran dalam melahirkan generasi ḥafīẓ Alquran yang memiliki ruhiah yang bagus dan akhlak mulia dengan dilandasi nilai-nilai Qurani. This paper is a field research which discusses the model of taḥfīẓ Quran formation at the Daarut Tauhiid Islamic Boarding School in Bandung. This research uses descriptive method using qualitative. The program which is the object of research is the taḥfīẓ Alquran Daarut Tauhiid Bandung program specifically for the santri taḥfīẓ Quran mukim student program. In collecting data using interview, observation, and documentation studies and triangulation techniques. While the technique of data analysis uses data reduction, displaying data, coding and concluding. Based on the results of research, vision, mission and the purpose of the birth of this program integrated between the life of the world and the hereafter. In addition, in the planning section, the curriculum used is a self-designed curriculum that is installed program background, program objectives, organizational structure, target targets and programs, reciutmen program, excavation of activities, learning training, materials, facilities and search assistance. support the taḥfīẓ Quran coaching program. While in its implementation, this coaching activity adapts to the santri because the santri have activities in the outside dormitory as students who are active on campus. In addition, the process of Islamic education is not only obtained from teaching and learning activities, but also required by the guidance of worship, discipline, and the very supportive Daarut Tauhiid Bandung environment. While evaluations needed in this training are evaluated by the students, evaluation of the performance appraisal program and program evaluation itself is carried out routinely in every schedule that has been determined. Whereas the model for the guidance of the taḥfīẓ Quran applied by Daarut Tauhiid Bandung in educating and developing santri taḥfīẓ Quran mukim students is a model of halaqah. The implication, the results of research on the model of guidance of the taḥfīẓ Quran can be used as an example in the implementation of the taḥfīẓ Quran program in giving birth to a generation of ḥafīẓ Quran who have a good spirit and noble character based on Quranic values.

Ukrainian industrial carpet weaving in 1940-1980s. in terms of the so called “folk handicrafts industry”: between folk art, artistic quality and economic efficiency

Background. Program of development of industrial carpet weaving in sub-Soviet Ukraine is considered. In this connection, influence of folk arts crafts on the the Ukrainian carpet weaving of a mass sample are analyzed: stylistics, artistic quality, production economy. Methodological approaches to the subject of folk crafts in the Soviet system are highlighted and the expediency of their revision from the standpoint of the present day is emphasized. Objectives. The Ukrainian Soviet carpet weaving as economic branch was a component of art industry in the segment of folk arts crafts. This direction implied production of artistic products with use of creative manual labor on the basis of folk art tradition. According to this principle, the carpet-making of republics in the USSR was developed where appropriate traditions were preserved. Today, in Ukraine there are fundamentally different socio-economic conditions that dictate new requirements including for carpet weaving. At the same time, in the national art history there is a need to revision the current approaches to the study of carpet weaving in the system of folk art, handicraft - industrial production and author's artistic textiles. The purpose of the paper is to raise the problem of rethinking and formulating modern approaches to the analysis of Ukrainian carpet weaving according to different systems of its production practices. "Neo-folklore" practice of industrial carpet weaving in Ukraine in the Soviet period generally established the meaning about Ukrainian Soviet carpet as a new phenomenon of Ukrainian folk art. The stylistic range here was determined "ethnographically", so production was concentrated in historically formed cells in Lviv region, Ivano-Frankivsk region, Transcarpathia, Chernivtsi region, Kyiv region, Poltava region, Vinnytsia region, Chernihiv region, Kirovograd region. The basis of products, in accordance with the traditions of national weaving, was made by hand-made ornamental smooth-wool carpet of vegetative and geometric types. Conclusion. Industrial carpet weaving from "living tradition" varied by a number of features, caused primarily by considerations of the economy of production. The economy of industrial carpeting is due to the pace of scheduled production. Therefore, for mass production, drawings with simpler compositions and larger forms of ornamentation were chosen. This worsened the artistic quality of the carpets, and consequently the demand for them sharply decreased. Changing the methodology of Soviet folk arts crafts - an analysis of them as an object of factory production, corresponds to the real practice of its time and relevant to study in the XXI century.

WORKING PROFESSIONALS AS PART-TIME ONLINE LEARNERS

This paper discusses a completely online graduate professional degree program at Drexel University. The paper provides an overview of the online initiative, including background, program development, and a description of the online environment. Following this, the paper contains a discussion of results of the degree program and proposes some characterizations of online learners and of desirable instructor attributes.

EVALUASI PROGRAM IMPLEMENTASI KURIKULUM 2013 MATA PELAJARAN SEJARAH DI SMA NEGERI PANDEGLANG

The purpose of this research is to obtain information comprehensively about the implementation of curriculum 2013 subjects history in SMA Negeri Pandeglang. This research uses CIPPmodel. The components that become the focus of this research are 1). Context, consist of program background, program constraints, feasibility study, 2). Inputh, consists of student, teachers, curriculum, infrastructure, financing, academic calender, 3). Process, consists of teacher copetence ;earningactivities in class 4). Product, consisting of sumatif value and formative value of leraners.This research uses qualitative methode combined with quantitative approach. The steps of the research begins by making evaluation criteria, the next stage of making the instrument research, making the instrument grille, data collection, data analysis and conclusions. The instrument validition test uses expert validation, and reliability test. Data collection techniques, using observation technique, interviews, documentation studies, and questionnaires. The result of reseearch show that context competent is in very good criteria, with 100% evaluation, 100 % input component is very good, 75 % good process component, and 100 % excellent product component. Thus, it can be concluded that the 2013 Curriculum implementation of history subjects can run very well. Abstrak Tujuan penelitian ini adalah untuk memperoleh informasi secara komprehensif tentang pelaksanaan program implementasi kurikulum 2013 mata pelajaran sejarah di SMA Negeri Pandeglang. Penelitian ini menggunakan model CIPP. Komponen- Komponen yang menjadi fokus penelitian ini yaitu (1) context, terdiri dari latar belakang program, kendala program, studi kelaikan; (2) input, terdiri dari peserta didik, guru, kurikulum, sarana prasarana, pembiayaan, kalender akademik; (3) process, terdiri dari kompetensi guru, kegiatan pembelajaran di kelas; (4) product, terdiri dari nilai sumatif dan nilai formatif peserta didik. Penelitian ini menggunakan metode kualitatif yang dipadukan dengan pendekatan kuantitatif. Langkah-langkah penelitian diawali dengan membuat kriteria evaluasi, tahap selanjutnya membuat kisi-kisi instrument, membuat instrument penelitian, pengumpulan data, analisis data dan kesimpulan. Uji Validitas instrumen menggunakan triangulasi sumber data. Teknik pengumpulan data menggunakan teknik observasi, wawancara, studi dokumentasi, dan angket. Hasil penelitian menunjukan bahwa komponen Context berada pada kriteria sangat baik dengan angka evaluasi 100%, komponen input 100 % sangat baik, komponen process 75 % baik, dan komponen product 100 % sangat baik.Sehingga, dapat disimpulkan bahwa impelemntasi Kurikulum 2013 mata pelajaran sejarah dapat berjalan dengan sangat baik dan efektif. Kata Kunci: Evaluasi Program, CIPP, Kurikulum 2013 Mata Pelajaran Sejarah

Design of Intelligent Measure and Control Software of Plant Growth Cabinet Based on Android System

Plant growth cabinet, as a kind of green, environmental, efficient, energy-efficient, closed plant growth environment, can provide the temperature, humidity and others that are required in the process of plant growth and development. We design an intelligent measure and control software based on Android system to achieve information collection and display of the environmental data in the cabinet and the plants’ morphological data. It also could remotely monitor the plant growth process in real time and do the intelligent regulation of the control node. In order to collect and send environmental data and video in real time that don’t affect the operation of the software interface, Android background Service technology has been adopted. The communication of Activity and Service that is realized by BroadcastReceiver, has realized the run of users operation interface and background program in the same time, improve the interactivity and real time of the software. The experimental results show that the software has realized the local and remote intelligent measure and control for the plant growth cabinet.

Intelligent Realization of Teaching Courseware Framework System

Usually, the teaching courseware that based on Web having a tree menu and can easily browse and links chapter and section. We study the development of a software system that can automatically generate courseware framework system with the menu tree. Here to generate static pages with dynamic page technology method, the key code of software framework system with the general characteristics stored in the database, and identify the dynamic location will be update. During the background program, according to the user input the information of chapter and section header, create the object code that can generate the directory tree structure; Finally, the teaching courseware framework system will be created that based on user input basic information and choose the courseware page template with the program stored in advance.

Electric Field Calculation Software for Epoxy Resin Casting Dry-Type Transformer Based on the VB

In the paper, combining the advantages of interface design of VB and secondary design of ANSYS, the electric calculating software for epoxy resin casting dry-type transformer was designed. In the procedure of designing transformer, designers only need to input the structure parameters and electrical parameters of the transformer, which would be transferred to ANSYS Parametric Design Language (APDL) program automatically. Then, the different loading conditions and post-procedure programs can be selected. Furthermore, VB calls ANSYS from the background program and reads the APDL file to calculate electric field distribution. Finally, the case analysis verifies that the software can establish the finite element model automatically and calculate the electrical field distribution under any fundamental frequency voltage and lighting surge.