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2021 ◽  
Vol 2096 (1) ◽  
pp. 012165
Author(s):  
Yu P Zarichnyak ◽  
A Yu Gorbunova ◽  
V A Korablev ◽  
V A Ivanov ◽  
N V Pilipenko ◽  
...  

Abstract A model of a tube with a square cross-section was compiled for the mathematical analysis of the mesotube in Cartesian coordinates, with the selection of an element of a representative volume. To estimate the effective thermal conductivity of the structure, the generalized theory of conductivity with linearization of heat flux streamlines was used. The presence of anisotropy leads to the division of the problem into a separate estimate of the longitudinal and transverse thermal conductivity. The cross-section of the model was divided into elementary sections by a system of auxiliary adiabatic and isothermal planes, then the sections of the model were presented in the form of thermal resistances connected in chains - electrical circuits. Using the analogy of the identity of thermal and electrical resistances, the total conductivity of the sections and the effective thermal conductivity of the structure were determined. This methodology satisfies the test for limit transitions.


PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249800
Author(s):  
Pierre Bougnères ◽  
Raphael Porcher ◽  
Laure Esterle ◽  
David Baker ◽  
Adrien de la Vaissière ◽  
...  

Hypospadias (H) is a common birth defect affecting the male urinary tract. It has been suggested that exposure to endocrine disrupting chemicals might increase the risk of H by altering urethral development. However, whether H risk is increased in places heavily exposed to agricultural pesticides, such as vineyards, remains debated and difficult to ascertain. The objective of the work is to test the possible association of H with residential proximity to vineyards. Residential address at birth of 8,766 H cases born 1980–2011 was taken from 17 specialized surgery centers. The geographical distribution of vineyards was obtained from the European Land Parcel Identification System (LPIS) and the distance of address to the nearest vineyard was computed. A first estimate of the variation of H relative risk with distance to vineyards was obtained using as controls 13,105 cryptorchidism (C) cases operated during the same period in the same centers. A separate estimate was obtained from a case-control study using “virtual controls” (VC) defined as points of the map sampled to match the demographic distribution of births within the recruitment territories of the study centers. Non-exposed patients were defined as those with a residence between 5,000 and 10,000 m from the closest vineyard. The residential distance to vineyard was smaller for H than for C cases (p<10−4). We found 42/8766 H cases (0.48%) and 50/13,105 C cases (0.38%) born to mothers living within 20 m of a vineyard. The odds ratios for H were 2.48 (CI: 1.0 to 5.1) and 2.4 (CI: 1.3 to 4.4), vs C or vs VC, respectively, when pregnant mothers lived 10–20 m from a vineyard. In conclusion, our study supports that children born to mothers living close to a vineyard have a two-fold increased risk of H. For environmental research, the use of VC provides an alternative to classical case control technique.


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