Overt Hyperthyroidism in Third Trimester of Pregnancy: A Case Report

Hyperthyroidism is a state of excessive thyroid function. The most common cause of hyperthyroidism is Graves’ disease. Overt hyperthyroidism if not treated can have serious outcome on the mother and the fetus. We present a pregnant women at 31 weeks of gestation presented with shortness of breath and palpitation with previous history of caesarean section and was treated with propyl thiouracil, beta blockers, antihypertensive drug, and during her course of treatment had Preterm Prelabor Rupture of Membrane with subsequent onset of labor and had normal vaginal delivery of 1.7 kg healthy baby. This report emphasize on the timely management of overt symptoms before the onset of labor.

Preference for and Sensitivity to Flavanol Mean Degree of Polymerization in Model Wines Is Correlated with Body Composition (P06-100-19)

Objectives It is known that the degree of polymerization (DP) of flavanol compounds influences the perceived bitter and astringent sensations of flavanol-rich foods. Previous research has indicated that preference for bitterness and astringency is related to health status (i.e., obesity) and sensitivity to bitter compounds such as 6-n-propyl-thiouracil (PROP). The objective of this study was to examine trends in liking, bitterness intensity, and astringency intensity of wine-like products with distinct flavanols of different DP in a consumer sensory panel when consumers were differentiated by phenotype. Methods Recruited panelists (n = 102) were segmented into different phenotypes based on body fat percentage (BF%), body mass index, PROP sensitivity, and stated preference for bitter foods. Differences in overall product liking, perceived bitterness intensity, and astringency intensity were observed between the three wine samples formulated to contain varying flavanol mDP. Results Considering the panelists altogether without segmentation, overall liking and bitterness liking decreased with increasing flavanol mDP, with concurrent increased perception of bitterness and astringency intensity. When looking at specific phenotypes, subjects of higher BMI and BF% showed significantly reduced ability to detect differences in bitterness and astringency intensity. Interestingly and unexpectedly, PROP sensitivity and self-reported bitterness preference did not significantly correlate with liking and intensity trends based on flavanol mDP. Conclusions Overall, these data suggest that BF% and BMI are greater predictors of liking and sensitivity to flavanol-rich foods compared bitterness sensitivity and self-reported bitterness liking. Reduced perception of bitterness and astringency associated with weight gain may impact selection and preference for these foods. Funding Sources Funding for this work was provided in part by the Virginia Tech Translational Obesity Research Graduate Interdisciplinary Research Program and the Virginia Tech Agricultural Experiment Station, and the Hatch Program, USDA-NIFA.

Carbimazole Induced Cholestatic Hepatitis in Grave’s Disease – A Case Report

Grave’s disease is the most common cause of hyperthyroidism. Antithyroid drugs are usually well tolerated in majority of patients but serious side effects in the form of allergy, agranulocytosis, aplastic anaemia, vasculitis, hepatitis etc occur in 3 – 12% of treated patients. Carbimazole is extensively used as the drug of choice except in pregnancy, where propylthiouracil is preferred. We report a case of 35 year old female patient with Grave’s disease, who developed cholestatic jaundice following administration of carbimazole for 2 months. Symptoms and laboratory abnormalities subsided on withdrawal of carbimazole and Grave’s thyrotoxicosis was managed with propranolol and propyl-thiouracil.