General and Particular Structural Characteristics of Acetylsalicylic Acid - Aspirine Chemical properties

Anti-inflammatory-analgesic medication is known to have a wide spread, its indications going beyond the area of rheumatology, aimed at various fields, cardiology, nephrology, hematology,neurology, etc. Many years of aspirin has constituted the health expectation of millions of patients. Most nonsteroidal anti-inflammatory analgesics (ASNS) are acidic compounds derived mainly from carboxylic acids and enolic acids. The non-acidic compounds are numerically reduced and relatively unrelated. The main effects of non-steroidal anti-inflammatory analgesics arise following antipyretic action, analgesic action and anti-immflamatory in varying proportions to each structural group. Each drug has the specificity of single actions, the global way of explaining the clinical effects remains little known. Anti-inflammatory (anti-termic) in acute rheumatism or other inflammatory joint disorders, anti-platelet antiaggregant, aspirin prevents aggregation of blood platelets (which have a role in stopping bleeding).This is why it is used to prevent thrombosis (clotting of blood in the arteries or veins) with an impOliant role in preventing myocardial infarction. The study includes 126 patients who often used aspirin. Interaction of aspirin with other drugs mainly occurs in the plasma albumin, platelets, liver, kidney and gastrointestinal tract. Considered a common drug, often used by patients without the physician�s indication, some of them under maintenance medication (corticosteroid, anticoagulants, antiplatelet, antidiabetics, cytostatics), aspirin may cause important complications.

Serositis: Comparative Analysis of Histological Findings and Pathogenetic Mechanisms in Nonbacterial Serosal Inflammation

Peritonitis is the established term for infective inflammation of the peritoneum, while serositis generally refers to nonorganismal inflammation in any serous cavity, including the peritoneum. In continuous ambulatory peritoneal dialysis (CAPD) literature, however, culture-negative peritoneal inflammation is referred to as “sterile” or “chemical” peritonitis. These terms not only imply unwarranted etiologic assumptions, but may also deflect attention from the existence of medical conditions to which the peritoneum is subject. This is evident in CAPD literature where there is little recognition that the peritoneum, as a member of the serosa and a secretor of lamellar bodies, is prey to a wide range of disorders. Thus before, during, and after CAPD, the membrane is liable to fall victim to disease states unconnected with the process of dialysis. Significant peritoneal pathology occurs as part of a pan-serositis, which may be metabolic (uremia, cholesterolosis), autoimmune (systemic lupus erythematosus, rheumatoid disease, acute rheumatism, endocrinopathies), genetic (recurrent hereditary polyserositis), allergic (eosinophilic serositis), and granulomatous in nature. This paper presents a comparative analysis of histopathological presentation and pathogenetic mechanisms involved in all forms of peritoneal serositis. It incorporates recent advances in molecular biology of the membrane into a holistic reappraisal of peritoneal pathology, revealing hitherto unrecognized homologies in peritoneal reaction to diverse disorders.

RED HAIR AND RHEUMATIC FEVER

A widely held popular belief in this country and in England until recently was that children with red hair were especially prone to develop rheumatic fever. Physicians as distinguished as Sir George Frederic Still (1868-1941) also shared this view as is shown in the following quotation which is taken from his famous textbook, Common Dlsorders and Diseases of Children. There is one further phenomenon which is noteworthy in rheumatic children and which is perhaps worth mentioning here, although it is necessarily noticeable also in adults-the association of red hair with rheumatism and rheumatic heredity. The following observation may serve to illustrate it. In four days there were amongst my out-patients eleven children with red hair. Of these, two were attending with articular rheumatism; one had occasional pain and swelling in the knees, his mother had red hair and frequent pain in the limbs, and her brother and sister had "rheumatic fever;" one had "pains in the knees" and his mother had "rheumatism;" three others showed a history of "rheumatic fever" in the mother or father; one was attending with chorea; one had a brother attending with articular rheumatism; only two out of the eleven showed no rheumatism or chorea in themselves or their families. Amongst 80 children with red hair (including the 11 already mentioned) 24 were attending with definite manifestations of acute rheumatism, articulan or cardiac or chorea; 6 had pains in the limb which were almost certainly rheumatic, and of the remaining 50 cases 17 showed a family history of acute rheumatism (including chorea) in parents or brothers or sisters; so that there was rheumatism either in the child or the family in 47 out of 80; i.e. in 58 percent.

Acute rheumatism—It’s problems and rehabilitation

No abstract available.