Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected samples. Using a rank-based pattern matching strategy based on the Kolmogorov–Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated 16 of our top predicted hits in live SARS-CoV-2 antiviral assays in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19.

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected samples. Using a rank-based pattern matching strategy based on the Kolmogorov-Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated sixteen of our top predicted hits in live SARS-CoV-2 antiviral assays in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19.

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expression signatures derived from publicly available data. We utilized three independent published studies to acquire or generate lists of differentially expressed genes between control and SARS-CoV-2-infected samples. Using a rank-based pattern matching strategy based on the Kolmogorov-Smirnov Statistic, the signatures were queried against drug profiles from Connectivity Map (CMap). We validated sixteen of our top predicted hits in live SARS-CoV-2 antiviral assays in either Calu-3 or 293T-ACE2 cells. Validation experiments in human cell lines showed that 11 of the 16 compounds tested to date (including clofazimine, haloperidol and others) had measurable antiviral activity against SARS-CoV-2. These initial results are encouraging as we continue to work towards a further analysis of these predicted drugs as potential therapeutics for the treatment of COVID-19.

HUBUNGAN MEKANISME KOPING DENGAN TINGKAT KECEMASAN PASIEN KANKER YANG MENJALANI KEMOTERAPI

Chemotherapy refers to a procedure treatment by using drugs that can kill cancer cells. The chemotherapy can cause anxiety of patient because they feel frightened physically and mentally. Therefore, the proper coping mechanism should be done to face this problem. This research aims to know about the correlation between coping mechanism and the anxiety level of the patient with cancer who was doing chemotherapy at RSUD Arifin Achmad Riau Province. This is quantitative research with descriptive correlation design and cross-sectional approach. The instrument used in this research is questionnaire. There is 96 respondent involved as the sample for this research. All of the respondents is the patient with cancer who was doing chemotherapy at RSUD Arifin Achmad Riau Province. The author used an accidental sampling method. The analysis style used in this research is the single variable with frequency distribution and two variable with the Kolmogorov-Smirnov statistic test. The result of this research shows that there is no significant effect of coping mechanism towards the anxiety level with p-value = 1,00 (p ≥ 0,05). The author gives a suggestion to RSUD Arifin Achmad Riau Province to increase the quality of coping mechanism to their patient.

A Comparison of Moment-Independent and Variance-Based Global Sensitivity Analysis Approaches for Wheat Yield Estimation with the Aquacrop-OS Model

The present work reports the global sensitivity analysis of the Aquacrop Open Source (AOS) model, which is the open-source version of the original Aquacrop model developed by the Food and Agriculture Organization (FAO). Analysis for identifying the most influential parameters was based on different strategies of global SA, density-based and variance-based, for the wheat crop in two different geographical locations and climates. The main objectives were to distinguish the model’s influential and non-influential parameters and to examine the yield output sensitivity. We compared two different methods of global sensitivity analysis: the most commonly used variance-based method, EFAST, and the moment independent density-based PAWN method developed in recent years. We have also identified non-influential parameters using Morris screening method, so to provide an idea of the use of non-influential parameters with a dummy parameter approach. For both the study areas (located in Italy and in China) and climates, a similar set of influential parameters was found, although with varying sensitivity. When compared with different probability distribution functions, the probability distribution function of yield was found to be best approximated by a Generalized Extreme Values distribution with Kolmogorov–Smirnov statistic of 0.030 and lowest Anderson–Darling statistic of 0.164, as compared to normal distribution function with Kolmogorov–Smirnov statistic of 0.122 and Anderson–Darling statistic of 4.099. This indicates that yield output is not normally distributed but has a rather skewed distribution function. In this case, a variance-based approach was not the best choice, and the density-based method performed better. The dummy parameter approach avoids to use a threshold as it is a subjective question; it advances the approach to setting up a threshold and gives an optimal way to set up a threshold and use it to distinguish between influential and non-influential parameters. The highly sensitive parameters to crop yield were specifically canopy and phenological development parameters, parameters that govern biomass/yield production and temperature stress parameters rather than root development and water stress parameters.

Constraining the SMEFT with Bayesian reweighting

We illustrate how Bayesian reweighting can be used to incorporate the constraints provided by new measurements into a global Monte Carlo analysis of the Standard Model Effective Field Theory (SMEFT). This method, extensively applied to study the impact of new data on the parton distribution functions of the proton, is here validated by means of our recent SMEFiT analysis of the top quark sector. We show how, under well-defined conditions and for the SMEFT operators directly sensitive to the new data, the reweighting procedure is equivalent to a corresponding new fit. We quantify the amount of information added to the SMEFT parameter space by means of the Shannon entropy and of the Kolmogorov-Smirnov statistic. We investigate the dependence of our results upon the choice of alternative expressions of the weights.

Remarks on Statistical Measures for Assessing Quality of Scoring Models

Granting a credit product has always been at the heart of banking. Simultaneously, banks are obligated to assess the borrower’s credit risk. Apart from creditworthiness, to grant a credit product, banks are using credit scoring more and more often. Scoring models, which are an essential part of credit scoring, are being developed in order to select those clients who will repay their debt. For lenders, high effectiveness of selection based on the scoring model is the primary attribute, so it is crucial to gauge its statistical quality. Several textbooks regarding assessing statistical quality of scoring models are available, there is however no full consistency between names and definitions of particular measures. In this article, the most common statistical measures for assessing quality of scoring models, such as the pseudo Gini index, Kolmogorov‑Smirnov statistic, and concentration curve are reviewed and their statistical characteristics are discussed. Furthermore, the author proposes the application of the well‑known distribution similarity index as a measure of discriminatory power of scoring models. The author also attempts to standardise names and formulas for particular measures in order to finally contrast them in a comparative analysis of credit scoring models.