Obesity and Cardiomyopathy

While much has been written about the syndrome of diabetic cardiomyopathy, clinicians and research scientists are now beginning to realize that an entirely unique syndrome exists, albeit with several commonalities to the diabetic syndrome, that being obesity cardiomyopathy. This syndrome develops independent of such comorbidities as hypertension, myocardial infarction and coronary artery disease; and it is characterized by specific alterations in adipose tissue function, inflammation and metabolism. Recent insights into the etiology of the syndrome and its consequences have focused on the roles played by altered intracellular calcium homeostasis, reactive oxygen species, and mitochondrial dysfunction. A timely and comprehensive review by Ren, Wu, Wang, Sowers and Zhang (1) identifies unique mechanisms underlying this syndrome, its relationship to heart failure and the recently identified incidence of COVID-19-related cardiovascular mortality. Importantly, the review concludes by advancing recommendations for novel approaches to the clinical management of this dangerous form of cardiomyopathy.

APPLICATION OF VACUUM THERAPY IN CONDITIONS OF COMPLEX TREATMENT OF COMPLEX FORMS OF DIABETIC SYNDROME

Summary. The aim of the study was to improve the results of treatment of patients with diabetic foot syndrome by applying a complex method of VAC-associated therapy. After 5 days of this treatment we enhanced the local blood flow of wounds from 27-31 to 52-54 mm Hg. (p<0.01), while in the comparison group the blood flow was 29-34 mm Hg, granulation tissue in the wound developed on average 4.93±0.64 days, which was significantly faster than in the control – 9,42±0.81 (p<0,05). Contamination of the wound of the main group before treatment was 8,4±0.14 Lg CFU/g of tissue, for 5 days – 2,8±0.21 Lg CFU/g of tissue, and the regenerative-inflammatory type of cytograms dominated. For 10 days the pathological microflora in the wound was absent, regional epithelialization appeared, the cytogram was of the regenerative type. In the comparison group, contamination before treatment was 8,1±0,17 Lg CFU/g (p<0.05), on the 5th and 10th day the indices were significantly higher than main group– 6,2±0.18 Lg CFU/g (p<0,01) and 3,8±0.19 Lg CFU/g (p<0,01), respectively and the cytograms were still of inflammatory type. The proposed comprehensive method of VAC-therapy provides an effective antibacterial, anti-inflammatory effect, promotes better regeneration and significantly improves the wound healing.

PENYEBARAN GUMPALAN DALAM PEMBULUH DARAH (DISSEMINATED INTRAVASCULAR COAGULATION) AKIBAT RACUN GIGITAN ULAR

Cases of snake bites were seldom happened in town. From the 2500–3000 world-wide distributed species of snakes, 500 are venomous. The snake produce some toxic substance which is dangerous in men , and could cause morbidity or mortality. It’s caused byophitoxaemia, which influence the permeability of capilers with consequence bleeding. There patients must be examined physically, localas well systemic. The laboratoric examinations were based on clinical symptoms, by determination of the snake venom causal and thesequalae in the human body, including coagulopathy, anemia as well as renal failure, etc. The snake venom may cause necrotic tissue offoot and anemia by trombocytopenia.The condition of this victim patient was severre due to his diabetic syndrome. This article presenteda study of snake bite incident on an old man with DIC laboratoric results, following anemia and renal failure which caused his death.

Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats

This study investigates the effects of intermittent overnight fasting in streptozotocin-induced diabetic rats (STZ rats). Over 30 days, groups of 5-6 control or STZ rats were allowed free food access, starved overnight, or exposed to a restricted food supply comparable to that ingested by the intermittently fasting animals. Intermittent fasting improved glucose tolerance, increased plasma insulin, and lowered Homeostatis Model Assessment index. Caloric restriction failed to cause such beneficial effects. Theβ-cell mass, as well as individualβ-cell and islet area, was higher in intermittently fasting than in nonfasting STZ rats, whilst the percentage of apoptoticβ-cells appeared lower in the former than latter STZ rats. In the calorie-restricted STZ rats, comparable findings were restricted to individual islet area and percentage of apoptotic cells. Hence, it is proposed that intermittent fasting could represent a possible approach to prevent or minimize disturbances of glucose homeostasis in human subjects.