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Author(s):  
Angélica B. Sanchez ◽  
Camila C. M. Garcia ◽  
Paolo Di Mascio ◽  
Marisa H. G. Medeiros

2020 ◽  
Vol 137 ◽  
pp. 109583
Author(s):  
Katarzyna Sznajder-Katarzyńska ◽  
Magdalena Surma ◽  
Wiesław Wiczkowski ◽  
Mariusz Piskuła

2019 ◽  
Vol 35 (12) ◽  
pp. 1311-1315
Author(s):  
Miki ISODA ◽  
Makoto FUKUMA ◽  
Akira HARATA

Author(s):  
E. G. Kuznetsova ◽  
O. M. Kuryleva ◽  
L. A. Salomatina ◽  
V. Yu. Belov ◽  
V. I. Sevastianov

Aim: to develop the emulsion transdermal therapeutic system (TTS) of cyclosporine and the research of its diffusion from TTS.Materials and methods. The quantitative evaluation of cyclosporine in model media was performed on liquid chromatograph Agilent 1100 G1311 with spectrophotometric detector G1315B (Germany). For the production of the emulsion matrix, the Heidolph DIAX900 disperser (Germany) and the ultrasonic homogenizer Hielscher UIS250V (Germany) were used. The cyclosporine diffusion from TTS through Strat-M membrane (25 mm in diameter, Merck Millipore) was studied using Copley diffusion analyser (Great Britain).Results. Using the developed method of micro-HPLC, it was established that the amount of cyclosporine passed through the Strat-M membrane over 24 hours from 10 sm2 TTS, containing 173 mg of the substance, was 5.9 mg. The estimated blood concentration is ~ 50 ng/ml which corresponds to the therapeutic maintenance blood concentration during organ transplantation (50–75 ng/ml).Conclusion. The model studies demonstrate the possibility of the cyclosporine transdermal transfer.


Molecules ◽  
2017 ◽  
Vol 22 (12) ◽  
pp. 2137 ◽  
Author(s):  
Tomasz Sawicki ◽  
Jerzy Juśkiewicz ◽  
Wiesław Wiczkowski
Keyword(s):  
Red Beet ◽  

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