rabbit atrium
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Heart Rhythm ◽  
2019 ◽  
Vol 16 (4) ◽  
pp. 494-501 ◽  
Author(s):  
Michael Biet ◽  
Anh Tuan Ton ◽  
Jean-Francois Delabre ◽  
Nathalie Morin ◽  
Robert Dumaine

2009 ◽  
Vol 33 (10) ◽  
pp. 1697-1703 ◽  
Author(s):  
Roman Laszlo ◽  
Christian Eick ◽  
Mareike Schwiebert ◽  
Birgit Schreiner ◽  
Hans-Joerg Weig ◽  
...  

2009 ◽  
Vol 36 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Shih-Huang Lee ◽  
Yao-Chang Chen ◽  
Chen-Chuan Cheng ◽  
Satoshi Higa ◽  
Yi-Jen Chen ◽  
...  

2008 ◽  
Vol 9 (3) ◽  
pp. 125-132 ◽  
Author(s):  
Roman Laszlo ◽  
Christian Eick ◽  
Norman Rueb ◽  
Slawomir Weretka ◽  
Hans-Joerg Weig ◽  
...  

2007 ◽  
Vol 376 (4) ◽  
pp. 231-240 ◽  
Author(s):  
Roman Laszlo ◽  
Christoph Winkler ◽  
Stefan Wöhrl ◽  
Ralf E. Wessel ◽  
Sara Laszlo ◽  
...  

2005 ◽  
Vol 67 (2) ◽  
pp. 274-282 ◽  
Author(s):  
E SOSUNOV ◽  
E ANYUKHOVSKY ◽  
D HEFER ◽  
T ROSEN ◽  
P DANILOJR ◽  
...  

1997 ◽  
Vol 75 (4) ◽  
pp. 255-262 ◽  
Author(s):  
A Qi ◽  
C Tang ◽  
J A Yeung-Lai-Wah ◽  
C R Kerr
Keyword(s):  

1995 ◽  
Vol 269 (2) ◽  
pp. H463-H472 ◽  
Author(s):  
G. R. Li ◽  
J. Feng ◽  
Z. Wang ◽  
B. Fermini ◽  
S. Nattel

The cardiac transient outward current (Ito) has been shown in several species to consist of two components: 1) a 4-aminopyridine (4-AP)-sensitive component (Ito1) and 2) a 4-AP-resistant component (Ito2). In rabbits, Ito2 is a Ca(2+)-dependent Cl- current [ICl(Ca)]; similar mechanisms have been suggested to underlie Ito2 in human atrium. We used whole cell patch-clamp techniques to define the mechanism of Ito2 (defined as the component resistant to 5 mM 4-AP) in human atrial myocytes, with parallel experiments performed in rabbit atrial cells. In rabbit atrium, Ito2 activated more slowly than Ito1 and had a bell-shaped current-voltage of Ito with properties similar to Ito2 in the rabbit, and a similar component recorded with pipette K+ replaced by Cs+ was suppressed by the substitution of methanesulfonate for Cl- in the superfusate. In human cells, a 4-AP-resistant Ito2 was recorded at a depolarizing pulse frequency of 1 Hz, but not at 0.1 Hz. Ito2 activated rapidly and inactivated earlier than Ito1, whereas its I-V relation was linear like that of Ito1. Ryanodine had no effect on human atrial Ito. When K(+)-free pipette solutions were used, no Ito was recorded in 30 human atrial myocytes, and external Cl- replacement with methanesulfonate failed to reveal an Ito. In 13 human myocytes, isoproterenol increased ICa but failed to activate an Ito compatible with ICl(Ca). Whereas caffeine suppressed human atrial Ito, it also suppressed Ito1 [in the presence of 200 microM Cd2+ to block ICa and 5 mM intracellular ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid to buffer intracellular Ca2+] in both human and rabbit atrium, indicating an action unrelated to Ca(2+)-triggered Ca2+ release. In conclusion, we were unable to demonstrate the presence of ICl(Ca) in human atrial myocytes, and the 4-AP-resistant component of Ito appeared to be due to 4-AP unblocking.


1993 ◽  
Vol 61 ◽  
pp. 268
Author(s):  
Kayo Matsushita ◽  
Anthony Kanai ◽  
Yuji Imaizumi ◽  
Wayne Giles ◽  
Minoru Watanabe

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