In this chapter an epistemology, based in the information, as the paradigm, that rules our lives, is stated - Informationism -. Information, or perhaps the message, reaches the brain as tiny impulses - quanta or useful information -, hitting and activating the neurones; as a consequence becoming quanta of useful information which produce knowledge, science and wisdom. Some definitions of information are quoted, as well as its connotations and peculiarities. The physical, psychic and pragmatic, etc. connotations of information are studied, including its energetic aspect; within a Cosmovision of it. Some neuronal theories are also studied.