Enantioselective C–H Functionalization toward Silicon-Stereogenic Silanes

In recent years, transition-metal-catalyzed enantioselective C–H bond functionalization has emerged as a powerful and attractive synthetic approach to access silicon-stereogenic centers, which continues to give impetus for the innovation of chiral organosilicon chemistry. This short review is aimed to summarize recent advances in the construction of silicon-stereogenic silanes via transition-metal-catalyzed enantioselective C–H functionalization. We have endeavored to highlight the great potential of this methodology and hope that this review will shed light on new perspectives, inspire further research in this emerging area.

Designing of tetrazole conjoined organosilane and organosilatrane via “click approach” using Zn(II) as catalyst: Potent Mycobacterium InhA inhibitor and optical recognition of Fe(III) and Cu(II) ions

Among azoles, tetrazoles are a class of heterocycles that have salient applications in almost every field of science. Organosilicon chemistry is pondering amalgamate of different moieties and has vast applications....

A Glimpse and Perspective of Current Organosilicon Chemistry from the View of Hydrosilylation and Synthesis of Silicon-Stereogenic Silanes

Silicon and its related organosilicon chemistry has become a mainstay in synthetic chemistry as they can participate in numerous organic transformations. Due to space limitations, this perspective is focused on a glimpse of current organosilicon chemistry from the view of catalytic hydrosilylation and synthesis of silicon-stereogenic silanes. The progress of the two topics fully illustrates that organosilicon chemistry has become a hot research field in recent years and will play a greater role in academic research and industrial applications of silicon element in the future.1 Introduction2 Hydrosilylation3 Catalytic Constructions of Silicon-Stereogenic Centers4 Conclusion and Perspective

Design, synthesis and photophysical aspects of 1,2,3-triazole appended schiff base functionalized silanes and silatranes

Organosilicon chemistry is appraised as the trunk of coalescence and structural manoeuvre of moieties. Schiff base compounds are popular auxiliary scaffolds having vast applications in the fields of biological activities,...

Simultaneous Synthesis and Characterization of in/out-Isomers of Disilabicyclo[14.14.14]alkanes

Facile and simultaneous synthesis of diphenyl-disilabicyclo[14.14.14]alkane in/out-isomers was achieved by using organosilicon chemistry. Although the formation of several in/out-isomers would be conceivable, only two diastereomers, i.e. the (traditional-)out,out-isomer and the...

Air-Stable, Zn+2 - Based Catalyst for Hydrosilylation of Alkenes and Alkynes

Hydrosilylation of C=C double and C≡C triple bonds is one of the most widely used processes in organosilicon chemistry, mostly catalyzed by Pt-based complexes. We report here the synthesis of...

On the Potential of Silicon as a Building Block for Life

Despite more than one hundred years of work on organosilicon chemistry, the basis for the plausibility of silicon-based life has never been systematically addressed nor objectively reviewed. We provide a comprehensive assessment of the possibility of silicon-based biochemistry, based on a review of what is known and what has been modeled, even including speculative work. We assess whether or not silicon chemistry meets the requirements for chemical diversity and reactivity as compared to carbon. To expand the possibility of plausible silicon biochemistry, we explore silicon’s chemical complexity in diverse solvents found in planetary environments, including water, cryosolvents, and sulfuric acid. In no environment is a life based primarily around silicon chemistry a plausible option. We find that in a water-rich environment silicon’s chemical capacity is highly limited due to ubiquitous silica formation; silicon can likely only be used as a rare and specialized heteroatom. Cryosolvents (e.g., liquid N2) provide extremely low solubility of all molecules, including organosilicons. Sulfuric acid, surprisingly, appears to be able to support a much larger diversity of organosilicon chemistry than water.