transmembrane electron transport
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Small ◽  
2021 ◽  
Vol 17 (32) ◽  
pp. 2170164
Author(s):  
Jacqueline M. Hicks ◽  
Yun‐Chiao Yao ◽  
Sydney Barber ◽  
Nigel Neate ◽  
Julie A. Watts ◽  
...  

Small ◽  
2021 ◽  
pp. 2102517
Author(s):  
Jacqueline M. Hicks ◽  
Yun‐Chiao Yao ◽  
Sydney Barber ◽  
Nigel Neate ◽  
Julie A. Watts ◽  
...  

2021 ◽  
Author(s):  
Jacqueline M. Hicks ◽  
Yun-Chiao Yao ◽  
Sydney Barber ◽  
Aleksandr Noy ◽  
Nigel Neate ◽  
...  

<p>Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, our ability to modulate membrane redox systems may give rise to opportunities to modulate underlying biology. The current work aimed to develop a wireless bipolar electrochemical approach to form on-demand electron transfer across biological membranes. To achieve this goal, we show that using membrane inserted carbon nanotube porins that can act as bipolar nanoelectrodes, we could control electron flow with externally applied electric fields across membranes. Before this work, bipolar electrochemistry has been thought to require high applied voltages not compatible with biological systems. We show that bipolar electrochemical reaction via gold reduction at the nanotubes could be modulated at low cell-friendly voltages, providing an opportunity to use bipolar electrodes to control electron flux across membranes. Our observations present a new opportunity to use bipolar electrodes to alter cell behavior via wireless control of membrane electron transfer.</p>


2021 ◽  
Author(s):  
Jacqueline M. Hicks ◽  
Yun-Chiao Yao ◽  
Sydney Barber ◽  
Nigel Neate ◽  
Julie Watts ◽  
...  

<p>Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, our ability to modulate membrane redox systems may give rise to opportunities to modulate underlying biology. The current work aimed to develop a wireless bipolar electrochemical approach to form on-demand electron transfer across biological membranes. To achieve this goal, we show that using membrane inserted carbon nanotube porins that can act as bipolar nanoelectrodes, we could control electron flow with externally applied electric fields across membranes. Before this work, bipolar electrochemistry has been thought to require high applied voltages not compatible with biological systems. We show that bipolar electrochemical reaction via gold reduction at the nanotubes could be modulated at low cell-friendly voltages, providing an opportunity to use bipolar electrodes to control electron flux across membranes. Our observations present a new opportunity to use bipolar electrodes to alter cell behavior via wireless control of membrane electron transfer.</p>


2021 ◽  
Author(s):  
Jacqueline M. Hicks ◽  
Yun-Chiao Yao ◽  
Sydney Barber ◽  
Nigel Neate ◽  
Julie Watts ◽  
...  

<p>Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, our ability to modulate membrane redox systems may give rise to opportunities to modulate underlying biology. The current work aimed to develop a wireless bipolar electrochemical approach to form on-demand electron transfer across biological membranes. To achieve this goal, we show that using membrane inserted carbon nanotube porins that can act as bipolar nanoelectrodes, we could control electron flow with externally applied electric fields across membranes. Before this work, bipolar electrochemistry has been thought to require high applied voltages not compatible with biological systems. We show that bipolar electrochemical reaction via gold reduction at the nanotubes could be modulated at low cell-friendly voltages, providing an opportunity to use bipolar electrodes to control electron flux across membranes. Our observations present a new opportunity to use bipolar electrodes to alter cell behavior via wireless control of membrane electron transfer.</p>


2014 ◽  
Author(s):  
Morgan Price ◽  
Jayashree Ray ◽  
Kelly M Wetmore ◽  
Jennifer V. Kuehl ◽  
Stefan Bauer ◽  
...  

Sulfate-reducing bacteria play major roles in the global carbon and sulfur cycles, but it remains unclear how reducing sulfate yields energy. To determine the genetic basis of energy conservation, we measured the fitness of thousands of pooled mutants ofDesulfovibrio alaskensisG20 during growth in 12 different combinations of electron donors and acceptors. We show that ion pumping by the ferredoxin:NADH oxidoreductase Rnf is required whenever substrate-level phosphorylation is not possible. The uncharacterized complex Hdr/flox-1 (Dde_1207:13) is sometimes important alongside Rnf and may perform an electron bifurcation to generate more reduced ferredoxin from NADH to allow further ion pumping. Similarly, during the oxidation of malate or fumarate, the electron-bifurcating transhydrogenase NfnAB-2 (Dde_1250:1) is important and may generate reduced ferredoxin to allow additional ion pumping by Rnf. During formate oxidation, the periplasmic [NiFeSe] hydrogenase HysAB is required, which suggests that hydrogen forms in the periplasm, diffuses to the cytoplasm, and is used to reduce ferredoxin, thus providing a substrate for Rnf. During hydrogen utilization, the transmembrane electron transport complex Tmc is important and may move electrons from the periplasm into the cytoplasmic sulfite reduction pathway. Finally, mutants of many other putative electron carriers ave no clear phenotype, which suggests that they are not important under our growth conditions.


2011 ◽  
Vol 100 (3) ◽  
pp. 131a-132a
Author(s):  
Bryan A. Fry ◽  
Gregory R. Wiedman ◽  
Christopher C. Moser ◽  
P. Leslie Dutton ◽  
Bohdana M. Discher

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