Rapid Transformation of Alkyl Halides into Symmetrical Disulfides Using Sodium Sulfide and Carbon Disulfide

An efficient one-pot reaction has been developed for the preparation of symmetrical disulfide derivatives directly from alkyl halides by reaction with a combination of sodium sulfide and carbon disulfide without requirement for any catalyst.

The synthesis and comparison of poly(methacrylic acid)–poly(ε-caprolactone) block copolymers with and without symmetrical disulfide linkages in the center for enhanced cellular uptake

A self-assembled poly(methacrylic acid)–poly(ε-caprolactone) block copolymer with a disulfide linkage, PMAA-b-PCL-SS-PCL-b-PMAA, was synthesized for enhanced cellular uptake due to a reduction response to GSH and pH-sensitive characteristics.

Synthesis of a disulfide functionalized diacetylenic derivative of carbazole as building-block of polymerizable self-assembled monolayers

A new symmetrical disulfide containing a diacetylenic unit and bearing a fluorescent carbazolyl end-group forming polymerizable self-assembled monolayers on metallic nanostructures has been synthesized. Suitable modifications of the synthetic steps involved in the synthesis of such derivatives were made in order to assure better synthetic pathway. Conversion of the tosylated derivative into the final symmetrical disulfide is carried out using sodium hydrosulfide (NaSH).

Trichloromonoxomolybdenum(V): An Efficient Catalyst for the Preparation of Symmetrical Disulfides from Thiols

Disulfides play important roles in biological and chemical processes. Oxidation of thiols is the most exploited method for disulfide synthesis. Trichloromonoxomolybdenum (V) has been found to be a superior oxotransfer reaction catalyst for the conversion of thiols to the corresponding disulfides in excellent yields under mild reaction conditions. A viable kilo-scale synthesis of the symmetrical disulfide was described. Simple workups, economical and practical are the some advantages of this method.

Determination of WR-1065 and WR-33278 by Liquid Chromatography with Electrochemical Detection: PVM 1:2002

A liquid chromatographic method using electrochemical detection is presented for measuring the thiol WR-1065 [2-(3-aminopropylamino) ethanethiol] and its symmetrical disulfide WR-33278 [NH2(CH2)3NHCH2CH2S]2. WR-1065 is the active, radioprotective drug derived from the phosphorothioate pro-drug WR-2721 (amifostine). External standard curves for both compounds were linear over the range of 40-200 pmol injected (r2 = 0.999 and 0.996 for the thiol and disulfide, respectively). The detection and quantitation limits for WR-1065 were 9 and 18 pmol, respectively, whereas the corresponding values for WR-33278 were 30 and 59 pmol, respectively. Within- and between-day determinations of measurement precision and accuracy for both compounds validated the suitability of this assay method.