First Report of Erythema Multiforme Minor Caused by Raloxifene Hydrochloride

Raloxifene is a drug used in postmenopausal women with osteoporosis. Although hot flashes are known side effects of raloxifene, to the best of our knowledge, erythema multiforme (EM) minor has not been previously reported. Herein, we report about a 74-year-old woman who developed EM minor after the drug alfacalcidol was changed to raloxifene to treat osteoporosis. Skin biopsy revealed a suspicious eczematous drug reaction. The drug-induced lymphocyte stimulation test showed a positive result. The stimulation index was 2.2, and there were no other suspected drugs. Based on these results, we diagnosed the condition as EM minor caused by raloxifene. The patient’s symptoms disappeared after the use of antihistamine drugs and topical steroids. In conclusion, raloxifene can cause EM minor in rare cases.

Histamine

Histamine has at least twenty-three known physiological functions, including playing a prominent role in immunologically mediated inflammation. The structure and metabolism of histamine is discussed, together with the various types of histamine receptors. Histamine plays a role in anaphylaxis, mast cell activation syndromes and mastocytosis and these conditions are relevant to anaesthetic practice. The antihistamine drugs and the H2 receptors agonists are discussed with regard to their role in anaesthesia.

Awareness on self-medications practices among dental students

Self-medication is indeed a practice where patients select and use drugs for either the management of auto-diagnosed physically or mental health problems. It was defined as the ingestion of drugs without consultation with a qualified doctor. The purpose of the research was to evaluate the perceptions and degree of self-medication practice amongst first-year dental students. This questionnaire-based survey was conducted among 100 first-year undergraduate dental students in Chennai. The questionnaire had 11 questions eliciting the practice of self-medication patterns among the students. The responses were recorded and . 61% of the respondents have the habit of self-medication. 43% said that they take for a headache, 21% said that for stomach pain, for fever 25% take self-medication and the rest said that they visit a doctor without taking any self-medication. 56% preferred medication, 9% preferred , 12% preferred Ayurveda and the rest 23% preferred the homemade medicines. 41% use antibiotic drugs, 47%use drugs and the rest 12% use antihistamine drugs. Around 71% said that they were aware of a drug overdose and the rest 29% said they were not aware. Self-medication was primarily used by dental students mainly for minor ailments with over the counter drugs. From the survey, we can conclude that there is a large number of students 61 % have the practice self-medication and so awareness must be created on it.

KAJIAN PERESEPAN OBAT ANTIHISTAMIN PADA PASIEN RAWAT JALAN DI SALAH SATU RUMAH SAKIT DI BANDUNG

Histamine is one of the factors that cause acute and chronic disorders, so it is necessary to investigate further the mechanism of antihistamines in the treatment of allergic diseases. Antihistamines are substances that can reduce or block the effects of histamine on the body by blocking histamine receptors. Antihistamines are one of the drugs that are often prescribed to children to the elderly. Thus the application of therapy in medicine is needed to ensure the use of appropriate drugs to prevent the occurrence of medication errors so that the goal of therapeutic effectiveness can be achieved. The purpose of this study was to determine the prescribing pattern of antihistamine drugs and assess the accuracy of the administration of antihistamines based on dose accuracy and potential drug interactions. Prescribing studies of this drug are descriptive quantitative and qualitative by using data sources in the form of patient prescription sheets taken retrospectively. The results of quantitative research data show that patients 57.23% were female, the highest age was 55-59 years old 12.26%, the most widely used drug was setirizine 72.48%, dose accuracy 89.60% and more doses 10.40%, the potential for drug interactions occurred in 27.83%, The drug that has the most potential for interaction is setirizine with theophylline.

Chiral separation of five antihistamine drug enantiomers and enantioselective pharmacokinetic study of carbinoxamine in rat plasma by HPLC-MS/MS

Chiral separation and pharmacokinetic study of antihistamine drugs.

Allergic rhinitis. Modern opportunities of pathogenetic therapy

Allergic rhinitis is a global public health problem at the present stage, given the high prevalence, the formation of therapy-resistant phenotypes, high comorbidity and the negative impact on all aspects of a patient’s life. Histamine is one of the main mediators of allergy, and therefore drugs number one in the treatment of patients with AR of all options are antihistamine drugs or H1-blockers. The innovative antihistamine drug of the second generation levocetirizine (Allerway®) prevents the development and facilitates the course of allergic reactions, also has anti-inflammatory and antiallergic action. Allerway® is bioequivalent to the original drug, has broad indications for use, has established itself as an effective drug with a good safety profile.