verapamil poisoning
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2021 ◽  
Vol 21 (4) ◽  
pp. 217
Author(s):  
Merve Havan ◽  
Tanıl Kendirli ◽  
Serhan Özcan ◽  
MelihTimuçin Doğan ◽  
AhmetOnur Yiğit ◽  
...  

2017 ◽  
Vol 74 (3) ◽  
pp. 278-281 ◽  
Author(s):  
Gordana Vukovic-Ercegovic ◽  
Natasa Perkovic-Vukcevic ◽  
Snezana Djordjevic ◽  
Zoran Segrt ◽  
Olivera Potrebic ◽  
...  

Introduction. During the last few years, intravenous lipid emulsions have been effectively used in treatment of acute poisonings with lipophilic substances, including verapamil. Case report. A 37-year-old women presented 1 hour after ingestion of 2.8 g verapamil with hypotension and complete heart block. Because of the applied standard therapy failure and further patients impairment, Intralipid? 20% was used. Sinus rhythm was restored, arterial blood pressure increased and verapamile concentrations, both total and free decreased. Conclusion. Intravenous lipid emulsion can be important in treatment of severe acute intoxication and cardiotoxicity caused by verapamil.


2015 ◽  
Vol 12 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Dmytro O. Kryshtal ◽  
Sheila Dawling ◽  
Donna Seger ◽  
Bjorn C. Knollmann

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Mirjam Osthoff ◽  
Christine Bernsmeier ◽  
Stephan C. Marsch ◽  
Patrick R. Hunziker

Cardiovascular shock due to verapamil intoxication is often refractory to standard resuscitation methods. Recommended therapy includes prevention of further absorption of the drug, inotropic therapy, calcium gluconate, and hyperinsulinemia/euglycemia therapy. Often further measures are needed such as ventricular pacing or mechanical circulatory support. Still, mortality remains high. Levosimendan, an inotropic agent, that enhances myofilament response to calcium, increases myocardial contraction and could therefore be beneficial in verapamil intoxication. Here, we report the case of a 60-year-old patient with clinically severe verapamil poisoning who presented with shock, bradycardia, and sopor. Standard therapy including high-dose inotropes failed to ameliorate the signs of intoxication. But additional therapy with levosimendan led to rapid improvement. Based on this observation, the literature is reviewed focusing on utilization of levosimendan in the treatment of calcium channel blocker overdose. We suggest to consider levosimendan as additional treatment option in patients with cardiovascular shock due to verapamil intoxication that are refractory to standard management.


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