The development of an intellectual property strategy for a biotechnology company

<p>The 2014 Masters of Advanced Technology Enterprise (MATE) programme is a multi-disciplinary course with the goal of creating teams that explore the challenges of creating successful technology enterprises. NacreTech is the result of one of the enterprises which has been developed within this course. It has found a market application for a nacre-like material as a biodegradable osteoconductive load bearing materials for orthopaedic implants and developed a target product profile to help guide further material development to out-compete existing materials on the market. In addition a proof of concept testing plan, intellectual property strategy and regulatory analysis has been conducted. This thesis is based on the author’s experience working within NacreTech while applying current knowledge and thinking surrounding protecting intellectual property for biotechnology. In particular, the author has investigated the intellectual property aspects, such as the requirements of the complete specification, filing dates and locations, and existing strategy models, required for commercialisation of the NacreTech biomaterial and examines the factors which influenced the development of the intellectual strategy.</p>

The development of an intellectual property strategy for a biotechnology company

<p>The 2014 Masters of Advanced Technology Enterprise (MATE) programme is a multi-disciplinary course with the goal of creating teams that explore the challenges of creating successful technology enterprises. NacreTech is the result of one of the enterprises which has been developed within this course. It has found a market application for a nacre-like material as a biodegradable osteoconductive load bearing materials for orthopaedic implants and developed a target product profile to help guide further material development to out-compete existing materials on the market. In addition a proof of concept testing plan, intellectual property strategy and regulatory analysis has been conducted. This thesis is based on the author’s experience working within NacreTech while applying current knowledge and thinking surrounding protecting intellectual property for biotechnology. In particular, the author has investigated the intellectual property aspects, such as the requirements of the complete specification, filing dates and locations, and existing strategy models, required for commercialisation of the NacreTech biomaterial and examines the factors which influenced the development of the intellectual strategy.</p>

Developing an Application for Researching the RSA Algorithm Behavior on a Multithread Platform

The article is focused on issues concerning the design of all needed software for researching the speed of the RSA encryption algorithm executed on a multithreaded platform. The base structure of the application is described in detail as well as the testing plan and algorithm. Shown is a method to handle and control all threads during the processes of encryption and description. The final results are visualized graphically though diagrams.

Strategic testing plan for Ambulatory Surgery Centers (ASCs) after the COVID-19 pandemic

As the curve continues to flatten during the SARS-CoV-2 pandemic, and more physicians resume outpatient clinical work, the question arises of how to ensure the safety of the patients and staff while performing cases. Many institutions and health care offices have turned to screening questionnaires to determine the likelihood of COVID-19 positivity. However, screening questionnaires are woefully inadequate as studies have shown that roughly 6.4% to 50% of patients may spread this virus without any symptoms. In this paper, we have outlined a proposal to restart elective procedures after the curve has flattened in a certain locale, particularly for ambulatory surgery centers (ASCs). Until additional data are collected for specific sensitivity and specificity values for PCR testing, we recommend performing two consecutive PCR tests to minimize false negative rates. The algorithm described in this paper can help ASCs begin their practices and provide local public health officials with valuable data that can help establish true sensitivity and specificity rates for these tests.

Serological testing in addition to PCR screening for the re-opening of American colleges and universities: potential for cost-savings without compromising pandemic mitigation

ImportanceThe addition of a serological testing could reduce the overall testing costs of a PCR-based SARS-CoV-2 testing reopening plan for colleges/universities in the United States, without compromising the efficacy of the testing plan.ObjectivesTo determine whether a college/university reopening SARS-CoV-2 testing plan that includes serological testing can be cost-saving compared to a PCR-only testing.Design, Setting, and ParticipantsWe assessed costs of serological testing in addition to PCR testing under various scenarios of university sizes (2000, 10,000, and 40,000) and epidemic conditions (initial antibody prevalence 2.5-15%; cumulative SARS-CoV-2 incidence during the school year 5-30%) of SARS-CoV-2 in the United States. We estimated total testing costs and relative percentage of cost-savings of different screening (i.e. targeted/ universal) and testing (i.e. in-sourcing/out-sourcing) scenarios between September 2020-May 2021.Main Outcomes and MeasuresTesting costs of serological testing and PCR testing, Relative percentage of cost saving by including serology testing in addition to PCR testing.ResultsIncluding baseline serology testing alongside routine regular PCR testing can reduce total test volumes and related costs throughout the school year. While the total testing cost is likely much lower if regular PCR testing is insourced compared to outsourced ($5 million vs $34 million for university size 10,000), including serologic testing could achieve the up to 20% cost-savings relative to PCR testing alone. The insourcing of serological testing when PCR testing is insourced can achieve greater cost-savings under high initial antibody prevalence (>5%) and cumulative incidence throughout the school year (>10%) at medium and large sized universities. If PCR testing is outsourced, however, the inclusion of serological testing becomes always preferred in most university sizes and epidemic conditions.Conclusions and RelevanceWhile regular PCR testing alone is the preferred strategy for containing epidemics, including serology testing may help achieve cost-savings if outbreaks are anticipated, or if baseline seropositivity is high.Key Points (96/100)QuestionCan the addition of a serological testing reduce the overall testing costs of a PCR-based SARS-CoV-2 testing reopening plan for universities in the United States?FindingsThis costing study suggested that inclusion of serological testing in addition to outsourced PCR testing as part of a university re-opening strategy could achieve cost savings of up to 20%. The amount of savings, or additional costs, is dependent on insourcing or outsourcing of testing, epidemic conditions and university size.MeaningThe relative cost-savings depend strongly on whether PCR and/or serology are being insourced or outsourced, university sizes and cumulative incidence.

Design and Testing Outline for a Free Running Model of a High Speed Craft

Hydrodynamics of High Speed Craft is a topic of very high interest for recreational boaters and industry professionals alike. This project aims to be a first step toward conducting such experiments in exposed outdoor environments. This paper will outline a preliminary design and testing plan of a free running model of a high speed craft. The proposed free running model will be subjected to all six degrees of freedom, self propelled, autonomously controlled, and will be exposed to weather elements.

AN INTELLIGENT FRAMEWORK FOR DYNAMIC TEST PLAN OF CLIENT/SERVER APPLICATIONS

To assist a solution to the problem of the test environment spanning multiple platforms, this paper proposes a decision support framework with the blackboard model to integrate all complementary features into a single automated test environment for multi-platform client/server applications. Before testing client/server applications, the input into this framework are testing tools with different approaches and client sites which are going to run the test. The planning agent will make a decision dynamically and produce a testing plan to allocate testing tasks to these testing tools to client sites. Two complementary features for testing client/server applications are illustrated in this paper to demonstrate how the framework works. The concept of mobile agents is applied to launch the test driver to different client sites, execute the tests and bring back the test results from client sites as well as the trace file from the server site for inspecting the interaction behavior among clients. Based on the multicast framework, the same test data can be broadcasted to multiple clients sites to run the tests simultaneously and the test results can be returned from client sites for examining the problem of repeated executions.