chiral atom
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Author(s):  
О.S. Verovka ◽  
◽  
А.О. Kolodiazhna ◽  

Koshland’s four-point location model is applied to consider some enzymatic reactions of deracemization. The sequen-tial model is a theory describing the cooperativity of protein subunits. It postulates that the conformation of the protein changes with each binding of a ligand, thus sequentially changing its affinity to ligands at adjacent binding sites. When the substrate binds to the active site of one subunit of the enzyme, the remaining subunits are activated. The possibility of the alternative binding of both substrates and products of the enzymatic reaction can be assessed on the basis of the known data on the structure of all four substituents at the chiral atom and their correspondence to the ligand specificity of the corresponding subsets of the enzyme. The made theoretical conclusions were tested by the example of the enzymatic deracemization of some hydroxyphosphonic acids. The replacement of ethoxyl groups at the phosphorus atom by isopropoxy groups and an increase in the volume of the substituent led to a significant increase in the enantiomeric excess of the hydrolysis product of hydroxyphosphonate. Hence, the conclusion is drawn that the key criterion for the efficient or inefficient passage of the reaction is the ratio of the sizes and the degree of hydrophobicity of the corresponding substituents at the asymmetric reaction center.


2019 ◽  
Vol 21 (11) ◽  
pp. 113021 ◽  
Author(s):  
Giuseppe Buonaiuto ◽  
Ryan Jones ◽  
Beatriz Olmos ◽  
Igor Lesanovsky
Keyword(s):  

Author(s):  
Stevin Carolius Angga ◽  
Dias Septiana ◽  
Suci Amalia ◽  
Warsito Warsito ◽  
Elvina Dhiaul Iftitah ◽  
...  

An enantiomer molecule consisted of the chiral atom has different structure conformations, which exhibit different activities as well. Yet, its separation considerably difficult since ordinary separation could not separate both molecules. One of the popular enantioseparations which are often used was using organic polymer monolithic column modified by ethylenediamine-β-cyclodextrin (EDA-β-CD) as the enantioseparations site. The aim of this research was to produce chiral stationary phase column for enantioseparations of (±)-citronellal. It was conducted by preparing monolithic column using monomer glycidyl methacrylate (GMA), trimethylolpropane trimethacrylate (TMPTMA) as crosslinker, 1-propanol, 1,4-butanediol, and water as pore-forming agents (porogens) in the presence of α,α'-azoisobutyronitrile (AIBN) as radical initiator inside polyetheretherketone (PEEK) tubing. It was then modified with EDA-β-CD synthesized from β-CD. Finally, it was installed as a high-performance liquid chromatography column. The result shows the produced chiral stationary phase column could separate (±)-citronellal at a retention time of 44.76 and 45.71 min.


2007 ◽  
Vol 40 (26) ◽  
pp. 9272-9278 ◽  
Author(s):  
Atsushi Narumi ◽  
Ryosuke Sakai ◽  
So Ishido ◽  
Masako Sone ◽  
Toshifumi Satoh ◽  
...  

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