Utilization of SARS-CoV-2 Wastewater Surveillance in Africa—A Rapid Review

Wastewater-based epidemiology for SARS-CoV-2 RNA detection in wastewater is desirable for understanding COVID-19 in settings where financial resources and diagnostic facilities for mass individual testing are severely limited. We conducted a rapid review to map research evidence on the utilization of SARS-CoV-2 wastewater surveillance in Africa. We searched PubMed, Google Scholar, and the World Health Organization library databases for relevant reports, reviews, and primary observational studies. Eight studies met the inclusion criteria. Narrative synthesis of the findings from included primary studies revealed the testing methodologies utilized and that detected amount of SARS-CoV-2 viral RNA correlated with the number of new cases in the studied areas. The included reviews revealed the epidemiological significance and environmental risks of SARS-CoV-2 wastewater. Wastewater surveillance data at the community level can be leveraged for the rapid assessment of emerging threats and aid pandemic preparedness. Our rapid review revealed a glaring gap in the primary literature on SARS-CoV-2 wastewater surveillance on the continent, and accelerated and adequate investment into research is urgently needed to address this gap.

Systematic Review of Intraoperative Blood Salvage in the Surgical Management of Craniosynostosis

Introduction/Background: The purpose of this systematic review is to assess the literature regarding complications associated with intraoperative blood salvage (IOBS) in the setting of surgical management of craniosynostosis. Methods: A systematic review was performed using PubMed/MEDLINE by 2 independent reviewers which included any primary literature investigating the use of IOBS in the surgical management of craniosynostosis. Results: The literature search resulted in 354 initial articles. After removing duplicates and articles not written in English, 330 articles underwent title review, resulting in 25 papers for abstract review. A total of 24 manuscripts were reviewed and 9 were deemed appropriate for inclusion of this systematic review. Two of the nine articles mentioned complications as a secondary objective. Conclusion: There is a paucity of current literature measuring the complications of IOBS in craniosynostosis patients undergoing cranial vault reconstruction.

Small and Medium Enterprises in Bolivia, a Look Back to the Future, 1900 - 2020

The main objective of this article is to analyze Bolivian small and medium enterprises (SMEs), their evolution, and their contribution to the country's economy. The globalization of markets is currently a reality to which companies are exposed for their survival, growth and development. In developing countries such as the plurinational State of Bolivia, this reality becomes more relevant due to the socioeconomic characteristics of the country, where the main economic activity is dependent on the export of non-renewable natural resources (natural gas and minerals), and to a lesser extent the export of primary products. In this context, the article shows that SMEs struggle to consolidate their position in local markets, and have a low participation in global markets. The article reviews relevant secondary and primary literature, and concludes that SMEs require public and private support to contribute to the promotion of entrepreneurial culture, enter into global production chains, develop technological and innovation capabilities, and achieve growth in a sustainable manner and with high levels of competitiveness. The research method used is the review of relevant primary and secondary bibliographic sources of information about the origins, evolution and current situation of SMEs in Bolivia, and about possible alternatives for growth and development.

Multi-inquiry hybrid e-learning: Instructor-learner experiences

Background: Hybrid teaching methodologies involve the purposeful combination of traditional teaching with technology advances. Despite some challenges, they have gained popularity recently, especially during the coronavirus pandemic. This study evaluated hybrid e-learning with multiple inquiries involving students’ receptiveness, preferences, behaviours and instructor observations. Method: The methodology involved a mixed-method approach with a qualitative observational case study, surveys and interviews for problem-based learning alternatives to traditional lectures. Instruction included: 1) Assigned primary literature reading with study questions to be completed before class; 2) Out-of-class online video-clips with visual, practical application (i.e. lithium and non-lithium induced tremor assessment) and online discussion in CANVAS Learning Management System; 3) Start-of-class quiz in ExamSoft, in-class team-based application questions with instructor-led discussion; 4) Out-of-class team final exam review assignment in CANVAS. Results: Qualitative themes were student engagement, flexibility, preferences, academic and non-academic stressors, etiquette, and defining responsibility for academic success. The majority of students preferred primary literature review, video clips, followed by online CANVAS discussions. Written assignments were the least desirable. Conclusion: These experiences are useful for qualitative evaluation of teaching and learning methods.

Electromechanical and Robotic Devices for Gait and Balance Rehabilitation of Children with Neurological Disability: A Systematic Review

In the last two decades, a growing interest has been focused on gait and balance robot-assisted rehabilitation in children with neurological disabilities. Robotic devices allow the implementation of intensive, task-specific training fostering functional recovery and neuroplasticity phenomena. However, limited attention has been paid to the protocols used in this research framework. This systematic review aims to provide an overview of the existing literature on robotic systems for the rehabilitation of gait and balance in children with neurological disabilities and their rehabilitation applications. The literature search was carried out independently and synchronously by three authors on the following databases: MEDLINE, Cochrane Library, PeDro, Institute of Electrical and Electronics Engineers, ScienceDirect, and Google Scholar. The data collected included three subsections referring to clinical, technical, and regulatory aspects. Thirty-one articles out of 81 found on the primary literature search were included in the systematic review. Most studies involved children with cerebral palsy. Only one-third of the studies were randomized controlled trials. Overall, 17 devices (nine end-effector systems and eight exoskeletons) were investigated, among which only 4 (24%) were bore the CE mark. Studies differ on rehabilitation protocols duration, intensity, and outcome measures. Future research should improve both rehabilitation protocols’ and devices’ descriptions.

The Adyton at the Temple of Apollo at Bassae: Multiple Cult Worship in the Adyton

<p>Situated on Mount Kotilion in the Peloponnese, the Temple of Apollo at Bassae sits high in the middle of a mountain range. Upon rediscovery, it became evident that most of the offerings had long since disappeared, and this was in turn paired with a lack of primary literature. Though the temple is mentioned in Pausanias’ work, discussion about the cultic aspects of the temple is severely lacking. This leads to a large gap in the knowledge of the temple’s religious function. It is for this reason that the architecture of Bassae is explored to help understand the cultic aspects of this temple. This thesis shows that multiple cults were celebrated at the temple of Bassae, and that there is a high probability that multiple cult worship occurred in the adyton of the building. The cult at Bassae has been celebrated since geometric times, and worship to Apollo was fairly consistent until the sanctuary’s demise in the third century BCE. Three epikleseis are often associated with this temple: Apollo Epikourios, Apollo Bassitas and Hyperborean Apollo. The epithet of Epikourios comes from Pausanias’ passage, and nowhere else. The original reason for this epithet may be either medicinal or martial, and both are explored within this thesis. Bassitas is another epithet provided. However, this is in the form of a singular archaeological find, a small bronze tablet found in the wider Kotilion sanctuary. The third epithet, Hyperborean, is a tenuous but commonly made connection. This epithet relies heavily on the localised subject matter of the sculptural programme at Bassae. The architecture of the building is also in need of discussion. The temple at Bassae is famed for its odd, and in some cases, unparalleled architectural design. The temple is on a north-south axis, and features not only a northern entranceway, but also an opening in the eastern wall, leading into the adyton. This eastern doorway allows light to enter twice a year, which hits the southern wall. The decorative features of the temple are unparalleled, with the first known Corinthian column and extended engaged Ionic columns. These unusual design features create a focus within the adyton. Within the adyton, four positions can be considered possible sites for housing offerings or cult statues. These include the southwest corner, the centre of the southern wall, the centre of the northern limits of the adyton directly south of the Corinthian column, and finally, the Corinthian column itself. The evidence for these positions being a focus for cult comes from architectural features, such as the paving of the adyton floor, the light phenomenon and a small plinth. These four positions are by no means definite, and this thesis discusses the probability of each of these positions in terms of the likelihood of them being the focus of a cult. While the southwest corner is the most likely position for a cult statue, the Corinthian column seems the least likely. The architecture at the Temple of Apollo at Bassae strongly suggests worship occurring inn the adyton of the temple, and it seems likely it was at least one of these three epithets that was celebrated in one of the four positions in the adyton.</p>

The Adyton at the Temple of Apollo at Bassae: Multiple Cult Worship in the Adyton

<p>Situated on Mount Kotilion in the Peloponnese, the Temple of Apollo at Bassae sits high in the middle of a mountain range. Upon rediscovery, it became evident that most of the offerings had long since disappeared, and this was in turn paired with a lack of primary literature. Though the temple is mentioned in Pausanias’ work, discussion about the cultic aspects of the temple is severely lacking. This leads to a large gap in the knowledge of the temple’s religious function. It is for this reason that the architecture of Bassae is explored to help understand the cultic aspects of this temple. This thesis shows that multiple cults were celebrated at the temple of Bassae, and that there is a high probability that multiple cult worship occurred in the adyton of the building. The cult at Bassae has been celebrated since geometric times, and worship to Apollo was fairly consistent until the sanctuary’s demise in the third century BCE. Three epikleseis are often associated with this temple: Apollo Epikourios, Apollo Bassitas and Hyperborean Apollo. The epithet of Epikourios comes from Pausanias’ passage, and nowhere else. The original reason for this epithet may be either medicinal or martial, and both are explored within this thesis. Bassitas is another epithet provided. However, this is in the form of a singular archaeological find, a small bronze tablet found in the wider Kotilion sanctuary. The third epithet, Hyperborean, is a tenuous but commonly made connection. This epithet relies heavily on the localised subject matter of the sculptural programme at Bassae. The architecture of the building is also in need of discussion. The temple at Bassae is famed for its odd, and in some cases, unparalleled architectural design. The temple is on a north-south axis, and features not only a northern entranceway, but also an opening in the eastern wall, leading into the adyton. This eastern doorway allows light to enter twice a year, which hits the southern wall. The decorative features of the temple are unparalleled, with the first known Corinthian column and extended engaged Ionic columns. These unusual design features create a focus within the adyton. Within the adyton, four positions can be considered possible sites for housing offerings or cult statues. These include the southwest corner, the centre of the southern wall, the centre of the northern limits of the adyton directly south of the Corinthian column, and finally, the Corinthian column itself. The evidence for these positions being a focus for cult comes from architectural features, such as the paving of the adyton floor, the light phenomenon and a small plinth. These four positions are by no means definite, and this thesis discusses the probability of each of these positions in terms of the likelihood of them being the focus of a cult. While the southwest corner is the most likely position for a cult statue, the Corinthian column seems the least likely. The architecture at the Temple of Apollo at Bassae strongly suggests worship occurring inn the adyton of the temple, and it seems likely it was at least one of these three epithets that was celebrated in one of the four positions in the adyton.</p>

Key articles and guidelines for the pediatric clinical pharmacist from 2019 and 2020

Purpose To summarize recently published research reports and practice guidelines deemed to be significantly impactful for pediatric pharmacy practice. Summary Our author group was composed of 8 board-certified pediatric pharmacists. Eight major themes were identified: critical care, hematology/oncology, medication safety, general pediatrics, infectious diseases, neurology/psychiatry, gastrointestinal/nutrition, and neonatology. The author group was assigned a specific theme(s) based on their practice expertise and were asked to identify articles using MEDLINE and/or searches of relevant journal articles pertaining to each theme that were published from January 2019 through December 2020 that they felt were “significant” for pediatric pharmacy practice. A final list of compiled articles was distributed to the authors, and an article was considered significant if it received a vote from 5 of the 8 authors. Thirty-two articles, including 16 clinical practice guidelines or position statements and 16 review or primary literature articles, were included in this review. For each of these articles, a narrative regarding its implications for pediatric pharmacy practice is provided. Conclusion Given the heterogeneity of pediatric patients, it is difficult for pediatric pharmacists to stay up to date with the most recent literature, especially in practice areas outside their main expertise. Over the last few years, there has been a significant number of publications impacting the practice of pediatric pharmacists. This review of articles that have significantly affected pediatric pharmacy practice may be helpful in staying up to date on key articles in the literature.

A review of the most impactful published pharmacotherapy-pertinent literature of 2019 and 2020 for clinicians caring for patients with thermal or inhalation injury

Keeping abreast with current literature can be challenging, especially for practitioners caring for patients sustaining thermal or inhalation injury. Practitioners caring for patients with thermal injuries publish in a wide variety of journals, which further increases the complexity for those with resource limitations. Pharmacotherapy research continues to be a minority focus in primary literature. This review is a renewal of previous years’ work to facilitate extraction and review of the most recent pharmacotherapy-centric studies in patients with thermal and inhalation injury. Sixteen geographically dispersed, board-certified pharmacists participated in the review. A MeSH-based, filtered search returned 1,536 manuscripts over the previous 2-year period. After manual review and exclusions, only 98 (6.4%) manuscripts were determined to have a potential impact on current pharmacotherapy practices and included in the review. A summary of the 10 articles that scored highest are included in the review. Nearly half of the reviewed manuscripts were assessed to lack a significant impact on current practice. Despite an increase in published literature over the previous 2-year review, the focus and quality remain unchanged. There remains a need for investment in well-designed, high impact, pharmacotherapy-pertinent research for patients sustaining thermal or inhalation injuries.