Frequency of plantar fasciitis due to improper shoes among different universities students

Back ground: study was conducted to determine the frequency of plantar fasciitis among three different universities students due to improper shoes. It was cross-sectional study. Plantar fasciitis is the inflammation of plantar fascia; plantar fascia is a thick connective tissue that forms the medial arch of foot. Improper shoes cause constant pressure and irritation on plantar fascia that leads to inflammation. When someone wears improper shoes, pronation activity of the foot decreased and it can lead to plantar fasciitis. Objective: The objective of study was to determine the frequency of plantar fasciitis due to improper shoes among three different universities students. Material and Methods: Study was cross-sectional and the data was collected from university students. Data was collected by using questionnaire and by applying statistical procedures results were concluded. Results: There were the following results in this study as, 35.5% participants without pain, 45% with mild pain, 16% with moderate pain and 3.6% with severe pain. There were 84% participants with single etiology, 13% participants with multiple etiology and 3% participants with nerve entrapment. There were 31 participants with no pain, 49 participants with mild pain, 11 participants with moderate pain and 2 participants with severe pain between ages 20-25 years. And between ages 26-30 there were 29 participants with no pain, 27 with mild pain, 16 with moderate pain and 4 participants with severe pain. Conclusion: Study concluded that 55.6% participants were between ages of 20-25 years. 54.4% participants were females, 59.2% participants were with no pain, 84% participants were with single etiology that is plantar fasciopathy. There were mostly participants suffered with mild pain and only 3.6% participants showed response with severe pain. There were mostly participants suffered with single etiology and the number of affected participants with plantar fasciitis slightly increased with age.

Identification of the Key Regulators of Spina Bifida Through Graph-Theoretical Approach

Spina Bifida (SB) is a congenital spinal cord malformation. Efforts to discern the key regulators (KRs) of the SB protein-protein interaction (PPI) network are requisite for developing its successful interventions. The architecture of the SB network, constructed from 117 manually curated genes was found to self-organize into a scale-free fractal state having a weak hierarchical organization. We identified three modules/motifs consisting of ten KRs, namely, TNIP1, TNF, TRAF1, TNRC6B, KMT2C, KMT2D, NCOA3, TRDMT1, DICER1, and HDAC1. These KRs serve as the backbone of the network, they propagate signals through the different hierarchical levels of the network to conserve the network’s stability while maintaining low popularity in the network. We also observed that the SB network exhibits a rich-club organization, the formation of which is attributed to our key regulators also except for TNIP1 and TRDMT1. The KRs that were found to ally with each other and emerge in the same motif, open up a new dimension of research of studying these KRs together. Owing to the multiple etiology and mechanisms of SB, a combination of several biomarkers is expected to have higher diagnostic accuracy for SB as compared to using a single biomarker. So, if all the KRs present in a single module/motif are targetted together, they can serve as biomarkers for the diagnosis of SB. Our study puts forward some novel SB-related genes that need further experimental validation to be considered as reliable future biomarkers and therapeutic targets.

Assessment of the Pain, Stress and Emotional Factor Related to the Occurrence of Bruxism

Summary Background/Aim: Bruxism is a parafunctional habit that has multiple etiology. Globally it is a widespread problem. The purpose of this study was to assess the presence of pain, stress and to understand the emotional factor and their relations to the occurrence of bruxism. Material and Methods: For the purpose of this paper, 40 patients with partial edentuloissness and bruxism were treated prosthetically and with night dentures. They were assessed for the degree of the pain they feel and were given questionnaires for the level of stress they feel and for their psychological situation. The control group consisted of 40 patients who were not treated but were diagnosed with the same methods like the previous group. Results: Patient feel pain from the consequences of bruxism, disregarding the statistical significance related to gender. Stress pays a major role as we live in a dynamic and demanding society. The more competitive and ambitious the person is the more there are possibilities for occurrence of bruxism. Emotions are a very complex matter that unconsciously can be connected to the presence of bruxism. Conclusions: Besides prosthetic rehabilitation, sometimes a multidisciplinary approach is needed. Dentists should be aware of their role as psychiatrist and need to be educated of the principles of a patient’s analysis and of the cognitive behavioral therapy.

Unusual clinical presentation of Guillain Barre syndrome: a case report

Background: Guillen barre syndrome is the most frequent cause of flaccid paralysis in the world, it is characterized by an acute demyelinating, autoimmune and multiple etiology polyneuropathy, among which are included infectious agents such as Campylobacter jejuni, Zika virus, of genetic and environmental factors. Case Report: We present the case of a 56-year-old Colombian male patient with a history of hypertension, who entered the intensive care unit with symptoms of atypical asymmetric motor neurological compromise, which rapidly progressed to ventilatory failure and subsequent confinement síndrome. Discussion: Guillen barre síndrome establishes a potentially fatal disease, the semiology of pain, paresthesia, symmetric-progressive, distal weakness, instability, hipo/areflexia, constitute a neurological emergency. There are Clinical variants establishing a great.