Role of Cardiac Biomarkers in Cancer Patients

In patients with cancer—and especially some specific subtypes—the heart can be pathologically affected due to the direct action of the tumor or its secretion products or due to the toxicity of some oncological treatments. Cardiac biomarkers have been investigated as inexpensive and easily accessible tools for prediction, early diagnosis, monitoring, or prognosis of various forms of cancer-related cardiac diseases. However, their clinical usefulness was not always clearly demonstrated in every area of cardioncology. For the identification of anthracycline related cardiotoxicity in the very early stages troponins proved to be more efficient detectors than imaging methods. Nevertheless, the lack of a standardized dosage methodology and of cardiotoxicity specific thresholds, do not yet allow to outline the precise way to employ them in clinical routine and to incorporate them into appropriate diagnostic or managing algorithms. Cardiac biomarkers proved also effective in patients with primary cardiac amyloidosis, in which both troponins and natriuretic peptides were able to predict adverse outcome, and carcinoid heart disease, where a precise diagnostic cut-off for N-terminal prohormone of brain natriuretic peptide (NT-proBNP) was identified to screen patients with valvular involvement. Likewise, NT-proBNP proved to be an excellent predictor of postoperative atrial fibrillation (POAF). On the contrary, evidence is still not sufficient to promote the routine use of cardiac biomarkers to early diagnose myocarditis due to immune check points inhibitors (ICIs), radiotherapy induced cardiotoxicity and cardiac complications related to androgenetic deprivation. In this review we present all the evidence gathered so far regarding the usefulness and limitations of these relatively inexpensive diagnostic tools in the field of cardio-oncology.

Do bilinguals outperform monolinguals in switching tasks? Contrary evidence for nonlinguistic and linguistic switching tasks

The benefits of bilingualism in executive functions are highly debated. Even so, in switching tasks, these effects seem robust, although smaller than initially thought (Gunnerud et al., 2020; Ware et al., 2020). By handling two languages throughout their lifespan, bilinguals appear to train their executive functions and show benefits in nonlinguistic switching tasks compared to monolinguals. Nevertheless, because bilinguals need to control for the interference of another language, they may show a disadvantage when dealing with task-switching paradigms requiring language control, particularly when those are performed in their less dominant language. The present work explored this issue by studying bilingualism’s effects on task-switching within the visual and language domains. On the one hand, our results show that bilinguals were overall faster and presented reduced switch costs compared to monolinguals when performing perceptual geometric judgments with no time for task preparation. On the other hand, no bilingual advantage was found when a new sample of comparable bilinguals and monolinguals completed a within-language switching task. Our results provide clear evidence favoring the bilingual advantage, yet only when the task imposes greater executive demands and does not involve language control.

The Socio-Cultural and Confessional Dimension of Delusional Ideas Content in the Spectrum of Non-Organic Psychotic Disorders

In the last decade, population clinical trials support the disabling nature of most globally diagnosed psychotic disorders. As a defining integral part of this pathology, the delusional idea considered to be the result of the inaccurate and abnormal interpretation of an external reality is individualized, despite the contrary evidence. This ideation’s clinical expression variability is influenced by a heterogeneous spectrum of biological and psychosocial factors, predisposing and/or favouring. This review’s main objective is to identify a series of relational patterns of the content of delusional ideation with socio-familial and cultural/confessional parameters to obtain a holistic approach to patients. Careful decipherment of these conditions can be the basis for developing new interventions that are much more effective in establishing a long-term diagnostic and therapeutic strategy.

The Epistemology of Prejudice Maintenance

But what about prejudice maintenance? Questions of acquisition aside, how could anyone be epistemically rational in retaining their prejudiced belief over time in the face of the significant amounts of contrary evidence confronting them in their everyday lives? This chapter argues that much of this evidence can be easily absorbed by prejudiced believers, in keeping with our best canons of epistemic rationality. Drawing on recent work on generic generalizations, the chapter argues that prejudiced beliefs are in no sense falsified by single contrary instances, or even larger swaths of them. Even when subjects are rationally required to recognize instances as providing contrary evidence, the correct response may simply be to reduce one’s credence in the relevant proposition. The result may be that they are somewhat less prejudiced than before. But they are still prejudiced, even as, by hypothesis, they have responded correctly to their evidence.

Evidential Preemption

So far the book has worked on the assumption that the confrontation with contrary evidence always requires rational believers to reduce their credence in the relevant propositions. This chapter introduces the notion of “evidential preemption,” which occurs when a testifier, in addition to offering testimony that p, also warns the hearer that others will try to persuade them of contrary views. This chapter argues that whenever it is rational for someone to accept the “ground-level” testimony on offer, it is also rational for them to accept the warning about what others will tell them. When they are subsequently confronted with this testimony, its evidential force has effectively been neutralized, since it is, essentially, information the subject has already conditionalized on. In this way, evidential preemption can serve as a tool for “epistemic inoculation,” all but ensuring that subjects cannot make beneficial use of the contrary evidence to correct their beliefs.

Forty years of declining burglary in the United States: Explanation and evidence relating to the security hypothesis

Residential burglary in the United States has declined by over 80% across the last four decades, representing a major social phenomenon that remains largely unexplained. International research indicates a need for investigation of the security hypothesis. Here, 50 years of studies are examined chronologically. A consistent narrative emerges which indicates that household security, largely absent in the 1970s, improved gradually over time. Improvement occurred via several mechanisms: the increased prevalence, quality, coverage, and routine use of security fixtures and fittings. In addition, crime displacement declined over time as fewer households offered easy crime opportunities, and the average age of burglars increased as juveniles found burglary increasingly difficult. Hence the study concludes that gradual household security improvements played a central role in the decline in residential burglary. While the findings suggest a considerable revison is needed to our understanding of burglary and burglars, the likelihood that 50 years of diverse burglary research points in the same direction by chance, and without significant contrary evidence, seems remote. Further implications for theory, policy, and research are identified.

Towards a Theological Overcoming of Anthropocentrism. The Vegetarian Choice

The article intends to demonstrate that a theology of vegetarianism is possible, despite some contrary evidence present in the biblical texts. Like other theologies dealing with issues not directly voiced in the Bible, it becomes possible to interpret the biblical statements in a new way, on the bases of a specific methodology. As a result, an objective comprehension will go back inductively to Sacred Scripture. The article advocates for applying this new method as well as for introducing its ethical implications into the Christian tradition. An additional supportive argument in favour of establishing the new understanding can be found in the history of the Roman Church, besides the consolidated custom of carnivorous nutrition: there has been no shortage of positions in favour of vegetarian asceticism. This stance was also represented by Thomas Aquinas. By valorizing classic Christian authors in favour of vegetarianism (starting with Jerome), the inauguration of the theology of vegetarianism becomes legitimised. Such an inauguration would reorient Christian thought toward reconsidering cosmology, ecology and topical contemporary issues such as anthropocentrism and speciesism.

Withdrawing treatment from patients with prolonged disorders of consciousness: the wrong answer is what the wrong question begets

In a recent paper, Charles Foster argued that the epistemic uncertainties surrounding prolonged disorders of consciousness (PDOC) make it impossible to prove that the withdrawal of life-sustaining treatment can be in a patient’s best interests and, therefore, the presumption in favour of the maintenance of life cannot be rebutted. In the present response, I argue that, from a legal perspective, Foster has reached the wrong conclusion because he is asking the wrong question. According to the reasoning in two leading cases—Bland and James—the principle of respect for autonomy creates a persuasive presumption against treatment without consent. Therefore, it is the continuation of treatment that requires justification, rather than its withdrawal. This presumption also works as the tiebreaker determining that treatment should stop if there is no persuasive evidence that its continuation is in the best interests of the patient. The presumption in favour of the maintenance of life, on the other hand, should be understood as an evidential presumption on a factual issue that is assumed to be true if unchallenged. However, the uncertainties regarding PDOC actually give reasons for displacing this evidential presumption. Consequently, decision-makers will have to weigh up the pros and cons of treatment having the presumption against treatment without consent as the tiebreaker if the evidence is inconclusive. In conclusion, when the right question is asked, Foster’s argument can be turned on its head and uncertainties surrounding PDOC weigh in to justify the interruption of treatment in the absence of compelling contrary evidence.

The Psychology of Creating Persons

Starting from the hero Jon Snow, in Game of Thrones, this chapter turns to several traditions of psychology to show the cognitive processes by which people put together small pieces of information in order to see others as “persons.” Public characters are a prominent special case of this process. According to affect control theory, strength, morality, and activity represent three basic dimensions along which people judge others—and build them into characters in public arenas. People make snap judgments about others’ morality and strength, and move away from these judgments reluctantly and slowly in the face of contrary evidence. People tend to see more consistency and coherence in others than the evidence warrants.

Why has burglary declined by 80 percent across four decades in the United States? Evidence relating to the security hypothesis

Residential burglary imposes significant financial and emotional costs upon victims and society overall. Yet residential burglary in the US has declined by over 80 percent across the last four decades, representing a major social phenomenon that remains largely unexplained. International research indicates a need for investigation of the security hypothesis. Here, 50 years of burglary studies are examined chronologically. A consistent narrative emerges which indicates that household security, largely absent in the 1970s, improved gradually over time. Improvement occurred via three mechanisms: the increased prevalence, quality, and routine use of security fixtures and fittings. In addition, crime displacement declined as fewer household presented easy crime opportunities, and burglars’ average age increased ( juveniles finding burglary increasingly difficult). The likelihood that 50 years of diverse evidence points in the same direction by chance, and without significant contrary evidence, seems remote. Hence the conclusion is that gradual household security improvements played a central role in the decline in residential burglary over time. Implications for theory, policy, and further research are identified.