A Framework for Evolution and Consciousness: Panpsychism Without Tears?

Giving an account of the relation between evolution and consciousness is painted as posing a dilemma between panpsychism, with minimal consciousness in every grain of matter, and radical emergence, with consciousness appearing as from nowhere in living structures. Panpsychism has been seen as suffering from a combination problem and radical emergence as unjustified in physics. The underpinning of physics now lies in field theory, which may provide a way out on both sides. Only, and always, in a field theory account do influences at different points in space-time combine in the same indivisible event. Radical emergence is also inherent to field theory. Moreover, by providing rich patterns of influence involving both discrete identities and quantitative values, field theory might provide a basis for sensed propositional meaning with subjects and predicates. Ordered condensed matter within living tissue may support unusual emergent dynamic units uniquely suited to building representations of the world with sensed meaning. The evolution of consciousness may then be seen as a tractable biological problem centred on increasingly sophisticated ways for external world dynamics to be mirrored by internal representations with semantic content, based in field relations within condensed matter with genetically encoded complex order.

COVID-19 - Modeling and Parameter Estimation for Brazil and Portugal: How predictable is the future?

This work addresses the COVID-19 pandemic on two fronts: proposing a system of ordinary differential equations to model it and fitting this model to Brazilian and Portuguese data. It presents estimations to important parameters for the infection dynamics, such as the percentage of asymptomatic individuals, and it stresses out that non-biological human aspects, for example, cultural, social, and economic, are not only impacted by the pandemic but also impact the pandemic dynamics itself. We state that, despite significant variations in the parameters, due to those human elements present in the contemporary pandemic, and despite the strong nonlinearities of the problem, wise human intervention is possible and able to minimize human losses. We show that the mortality rate does not behave as one would expect for a biological problem, independent of cultural aspects, and we also point to possible dates for the peaks of infection in both countries depending on the control of the transmissibility.

An overview of machine learning methods for monotherapy drug response prediction

For an increasing number of preclinical samples, both detailed molecular profiles and their responses to various drugs are becoming available. Efforts to understand, and predict, drug responses in a data-driven manner have led to a proliferation of machine learning (ML) methods, with the longer term ambition of predicting clinical drug responses. Here, we provide a uniquely wide and deep systematic review of the rapidly evolving literature on monotherapy drug response prediction, with a systematic characterization and classification that comprises more than 70 ML methods in 13 subclasses, their input and output data types, modes of evaluation, and code and software availability. ML experts are provided with a fundamental understanding of the biological problem, and how ML methods are configured for it. Biologists and biomedical researchers are introduced to the basic principles of applicable ML methods, and their application to the problem of drug response prediction. We also provide systematic overviews of commonly used data sources used for training and evaluation methods.

Application of Psychometric Approach for ASD Evaluation in Russian 3–4-Year-Olds

Background: Autistic spectrum disorder (ASD) is a significant socio-biological problem due to its wide prevalence and negative outcomes. In the current study, we aimed to develop an autism scale for early and accurate differentiation of 3- to 4-year-olds at risk for ASD since there is no systematic monitoring of young children in Russia yet. Methods: The total sample (N = 324) included 116 children with ASD, 131 children without ASD (healthy controls), and 77 children with developmental delay (DD). An online survey of specialists working with children was conducted based on a specially designed autism questionnaire consisting of 85 multiple-choice tasks distributed across 12 domains. Initially, each child was assessed by 434 items using a dichotomous scale (0 = no, 1 = yes). Factor and discriminant analyses were performed to identify a compact set of subscales that most accurately and with sufficient reliability predicted whether a child belongs to the ASD group. Results: As a result, four subscales were obtained: Sensorics, Emotions, Hyperactivity, and Communication. The high discriminability of the subscales in distinguishing the ASD group from the non-ASD group was revealed (accuracy 85.5–87.0%). Overall, the obtained subscales meet psychometric requirements and allow for creating an online screening system for wide application.

Ophthalmologist’s patient: psychological peculiarities of work in case of “catastrophic” diagnoses

A typical mistake in glaucoma therapy comes down to the fact that the doctor treats a biological problem without thin­king about its psychological effect on the patient’s quality of life, about the patient’s ability to assess this problem, about the level of social readaptation and the patient’s social support. All these aspects must be taken into account, remembering that the biological problem will remain with the patient for life. Often, already from the first stage of glaucoma, psychological defense mechanisms lead to distortion of information about the disease, which entails an inadequate assessment of the disease. As a result, cooperation with the patient begins to become more difficult — low or no compliance is formed. Patients do not adhere to the therapy regimen and make attempts to find any alternative methods of treatment. They do not believe that citicoline, for example, has to be taken all their lives to be effective, and instead, without immediate results, they stop taking the drug. And our task is to explain to patients the importance of the right attitude to treatment. Thus, the success of psychological adaptation and therapy of glaucoma will fully depend on what information the patient receives from the doctor, and whether he can correctly evaluate this information. Western countries have long developed a protocol for deli­vering “bad news”, which is being studied at medical universities in North America and Europe in the “Physician Communication Skills” course. In Ukraine, we have just started teaching this six-step protocol (the English abbreviation SPIKES): 1. Setting up the interview. 2. Assessing the patient’s perception. 3. Obtaining the patient ‘s invitation. 4. Giving knowledge and information to the patient. 5. Addressing the patient’s emotions with empathic responses. 6. Strategy and summary. Considering all of the above, the article will focus on the psychological problems of glaucoma; how and by what means they can be measured; the protocol for delivering “bad news” will be reviewed; aspects of the doctor’s behavior depending on the characteristics of their patients will be discussed.

Trapping Fruit Flies: A Guided-Inquiry Lab Approach to Teaching Biology to Nonmajors

Current trends in education include offering students authentic experiences that generate broad interest, develop their cognitive flexibility, and prepare them to be scientifically literate members of society. We present a three-part guided-inquiry lab that gives students practice applying the scientific method to control fruit fly outbreaks and reinforces concepts related to behavioral and sensory biology. This activity was designed and tested at a four-year university but can be modified for high school courses. Students are “employed” by the fictional Fruit Fly Trap Company to design a device to maximize capture of female fruit flies using environmentally friendly lures. During this lab, students collaborate to conduct literature searches, ask research questions, develop hypotheses, design experiments, collect and analyze data, and present findings in a short oral presentation. In our implementation of this module in a biology class for nonmajors in fall 2017, over 50% of students reported that the literature research, scent experiments, trap construction, trap testing, and PowerPoint presentation were extremely effective in teaching science process and biological problem-solving skills. Over 70% of our students rated the practical, hands-on elements of the activity as enjoyable. Overall, students generally enjoyed the lab and reported positive impacts on their learning.

Widespread non-apoptotic activation of Drosophila Caspase-2/9 limits JNK signaling, macrophage proliferation, and growth of wound-like tumors

SummaryResistance to apoptosis due to caspase deregulation is considered one of the main hallmarks of cancer. However, the discovery of novel non-apoptotic caspase functions has revealed unknown intricacies about the interplay between these enzymes and tumor progression. To investigate this biological problem, we capitalized on a Drosophila tumor model highly relevant for humans that relies on the concomitant upregulation of EGFR and the JAK/STAT signaling pathway. Our results indicate that widespread non-apoptotic activation of initiator caspases limits JNK signaling and facilitates cell fate commitment in these tumors, thus preventing the overgrowth and exacerbation of malignant features. Intriguingly, these caspase functions are strongly linked to the ability of these enzymes to control the recruitment and subsequent proliferation in situ of macrophage-like cells on the tumor. These findings assign novel tumor-suppressor activities to caspases independent of apoptosis, while providing highly relevant molecular details to understanding their diverse contribution during tumor progression.

Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specific mtDNA segregation pattern, with few tissues that do not show segregation. The driving force for this dynamic complex pattern has remained unexplained for decades, challenging our understanding of this fundamental biological problem and hindering clinical planning for inherited diseases. Here, we demonstrate that the nonrandom mtDNA segregation is an intracellular process based on organelle selection. This cell type–specific decision arises jointly from the impact of mtDNA haplotypes on the oxidative phosphorylation (OXPHOS) system and the cell metabolic requirements and is strongly sensitive to the nuclear context and to environmental cues.