Ant colony optimization based founder sequence reconstruction

Reconstruction of founder (ancestor) genes for a given population is an important problem in evolutionary biology. It involves finding a set of genes that can combine together to form genes of all individuals in that population. Such reconstruction can be modeled as a combinatorial optimization problem, in which we have to find a set of founder (gene) sequences so that the individuals in a given population can be generated by the smallest number of recombination on these founder sequences. In this paper we propose a novel ant colony optimization algorithm (ACO) based method, equipped with some important improvements, for the founder gene sequence reconstruction problem. The proposed method yields excellent performance when validating on 108 test sets from three benchmark datasets. Comparing with the best by far method for founder sequence reconstruction, our proposed method performs better in 45 test sets, equally well in 44 and worse only in 19 sets. These experimental results demonstrate the efficacy and perspective of our proposed method.

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

Key Points Key biological features of MDSs are explained by NLRP3 inflammasome activation, which drives pyroptotic cell death and β-catenin activation. Alarmin signals and founder gene mutations license this redox-sensitive inflammasome platform.