immunological target
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Author(s):  
Mateusz Sikora ◽  
Sören von Bülow ◽  
Florian E. C. Blanc ◽  
Michael Gecht ◽  
Roberto Covino ◽  
...  

The severity of the COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, calls for the urgent development of a vaccine. The primary immunological target is the SARS-CoV-2 spike (S) protein. S is exposed on the viral surface to mediate viral entry into the host cell. To identify possible antibody binding sites not shielded by glycans, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four full-length, fully glycosylated and palmitoylated S proteins. By mapping steric accessibility, structural rigidity, sequence conservation and generic antibody binding signatures, we recover known epitopes on S and reveal promising epitope candidates for vaccine development. We find that the extensive and inherently flexible glycan coat shields a surface area larger than expected from static structures, highlighting the importance of structural dynamics in epitope mapping.


2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Giovanni Salvatori ◽  
Laura Luberto ◽  
Mariano Maffei ◽  
Luigi Aurisicchio ◽  
Giuseppe Roscilli ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 100280-100287 ◽  
Author(s):  
Christopher A. Schutt ◽  
Leonardo Mirandola ◽  
Jose A. Figueroa ◽  
Diane D. Nguyen ◽  
Joehassin Cordero ◽  
...  

2017 ◽  
Vol 24 (4) ◽  
pp. 550-551
Author(s):  
Orhan Aktas

The case report by Puthenparampil et al. suggests that heterogeneity of demyelinating diseases may be more complex than expected. The authors describe a female patient starting with isolated but relapsing myelitis (in the absence of oligoclonal bands or anti-aquaporin 4 antibodies) and later experiencing the simultaneous occurrence of inflammatory demyelinating polyneuropathy and of a tumefactive hippocampal brain lesion responsive to immunotherapy. As testing for antibodies against established and novel auto-antigens including neurofascin-155 was negative, this case may be regarded as an example for the unfolding spectrum of combined central and peripheral demyelination (CCPD) syndromes with so far unknown immunological target(s).


2015 ◽  
Vol 62 (7) ◽  
pp. 1144-1148 ◽  
Author(s):  
Judith Weiland ◽  
Alex Elder ◽  
Victoria Forster ◽  
Olaf Heidenreich ◽  
Steffen Koschmieder ◽  
...  

Immunotherapy ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 459-463 ◽  
Author(s):  
Benazir Saleem ◽  
Ceara AE Walsh ◽  
Paul Emery

2008 ◽  
Vol 128 (7) ◽  
pp. 1710-1718 ◽  
Author(s):  
Flor Evangelista ◽  
David A. Dasher ◽  
Luis A. Diaz ◽  
Phillip S. Prisayanh ◽  
Ning Li

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