Risk factors, clinical outcome and complications of Common Gynecological Surgeries at Zagazig University Hospital, Egypt

In present era, with the availability of better health care facilities and understanding of health issues, women are experiencing longer life expectancy and using more gynecological services, so obviously there is increase in gynecological surgeries. Any surgical procedure carries risks of complications. The risk of postoperative complications depends on individual characteristics, including age, medical comorbidities, and functional status. The aim of study was to reduce rates of mortality/morbidity among women who undergo surgical gynecological intervention at Zagazig University Hospital. This study included 212 cases were retrived prospectively in a cross sectional study. They underwent gynecological interventions. Our study group was 212 cases 24 cases ended with morbidity with percentage of 11.3% and 2 cases ended by death with percentage of 0.9% . This study shows that the most frequent complications among the studied group were septic wound infection (2.4%), bladder injury (2.4%), respiratory tract infection (1.9%),Venous thromboembolism(VTE) (1.9%) and GIT injury (1.4%). This study explains that there were two mortality cases the first case died on table due to primary hemorrhage during hysterectomy operation as a result of great vessel injury and the other case died during hysterectomy operation due to venous thromboembolic catastrophe (Pulmonary embolism). During post-operative period, she developed hypoxia; therefore, she was referred to ICU. Unfortunately, the patient was diagnosed as pulmonary embolism; thus, she was admitted at ICU for 3 days, but she finally died. Conclusion With the availability of highly skilled personnel with improved surgical expertise, safe anesthesia and collaboration of other specialized medical personnel, the major complications and mortality rate will decrease, but the postoperative complications like, fever, respiratory tract infection, septic wound and DVT still frequent in a significant number of patients in our community, which brings about much distress to the patients.

Traditional Remedies for Wound Healing: A Review

Wounds are a natural part of everyday life that can be successfully treated with the knowledge of Ayurveda. Ayurveda is the study of science that is based on herbal remedies. A wound must progress through vrana shodhana (wound purification) and vrana roopana (wound healing) and pass through the four stages of wound healing; dushta vrana (septic wound), shudh vrana (clean wound), roohyamana vrana (healing wound), and roodha vrana (healed wound). Through this, Ayurveda has revealed knowledge for treating conditions that can’t be treating by the modern medicine. Ghee-based herbal formulations claimed to promote wound healing in traditional practices. This article aims to provide probable scientific explanations for using medicated ghrita (ghee) as wound healing formulation in Ayurvedic system of medicine and its clinical importance. Keywords: Ayurveda, Wound, Ghrita, Wound healing.

Lytic Bacteriophages and Phage Cocktails Seem to be a Future Alternative Against Multi-Drug Resistant Bacterial Infections

Lytic bacteriophages have the efficacy to act and eradicate pathogenic bacteria as an attractive tool in the near future. Bacteriophages specifically kill multidrug-resistant bacteria even which have the capacity to form biofilms. The present review mainly focused on the efficacy of bacteriophages and cocktails as therapeutic agents against predominate MDR-bacteria and their biofilms which are isolated from septic wound infections. The body of evidence includes data from studies investigating bacteriophages from sewage samples as novel antibacterial and antibiofilm agents against pathogenic bacteria. The goal of this review is to present an overview on predominant bacteria from septic wound infection, the biofilm-forming capacity of bacteria, lytic effect of bacteriophages and phage cocktails with an emphasis on the application of bacteriophages against septic wound causing bacteria.

The estimation of the treatment effectiveness of the experimental soft tissues septic wound with the application of polymer antimicrobial compound in the depo-form of decametoxinum

Today septic wound treatment demands from a surgeon a multipurpose approach. For the reason of the microorganisms’ resistance to antibiotics, specialists have to use more often various dosage forms of antiseptics. According to the topical cement antibiotic form, which is used in traumatology and orthopedics, the new antimicrobial polymer compound was designed, that contains decametoxinum. Previous studies in vitro proved the sustained-release of the agent. The purpose of our experiment is to study the treatment effectiveness of the new polymer compound dosage form of the decametoxinum in comparison with other treatment methods of septic-necrotic processes of soft tissues. We estimated on laboratory animals the effectiveness of alternative treatment approaches of the septic wound management, which were caused by S.аureus and P.аeruginosa, in different groups, including those where the new antiseptics’ dosage form was used. Three groups of the septic experimental wounds were treated by the principles of monotherapy — with liquid solution of decametoxinum, depo-form of decametoxinum and with intramuscular (IM) injection of etiological antibiotic — amikacin. The animals in fourth group received multipurpose treatment — depo-form of the decametoxinum topically with amikacin IM. Fifth group — was the control one. Visual estimation, bacteriological investigations were held according to the stages of the wound healing process. Macroscopic assessment of the wounds showed the best treatment effect in groups with depo-form application, especially during the first stage of the healing process. Finally, it was revealed that in groups where different dosage forms of decametoxinum were used the effectiveness of decontamination process was almost the same. But the wounds’ redressing with depo-form of decametoxinum was carried out once in three – four days, in comparison with daily redressings of the wounds in the group where it’s liquid form was used. The sanitation effect was more vital against P.aeruginosa, then in relation to S.aureus. The best results were received in the multipurpose treatment group — the complete bactericidal effect against all microbe populations was achieved. That grants us an idea about possible potentiation of the system antibiotic by topical antiseptic.