TO EVALUATE COMPLICATION OF LAPAROSCOPIC TRANSPERITONEAL PYELOLITHOTOMY FOR MANAGEMENT OF RENAL PELVIC STONES

Background: To evaluate complication of laparoscopic transperitoneal pyelolithotomy for management of renal pelvic stones Methods: This study has been conducted in the Department of General surgery, Indira Gandhi Medical College, Shimla on selected patients of Renal pelvis stones admitted in institution Results: There were no major postoperative complications. Two patient developed mild low grade fever which subsided on oral antipyretic medication. One patient had a cough and one patient had ileus. Conclusion: We concluded that there were no major intraoperative or postoperative complications were seen in our study. Keywords: Laparoscopic Transperitoneal Pyelolithotomy, Pelvic stone, Complication

Prevalence and Current Practices of Self-Medication among Students of the Biomedicine Degree at the Health Sciences School

Self-medication is often seen as a solution for the immediate relief of symptoms, however, bringing serious consequences to consumer's health and serious public health problems in Brazil and the world. Still, regarding self-medication, the conduct of University students in the health area is observed, since the habit in this group is high. Given these facts and the need for epidemiological and toxicological evidence on self-medication of this school group, this study aims to verify the prevalence of self-medication in Biomedicine Degree students of the Universidade Brasil. It is a cross-sectional study conducted with 63 scholars from the first three graduation years of the Biomedicine degree at the Universidade Brasil, in Fernandópolis, São Paulo. A validated questionnaire with social and medication consumption variables was applied, followed by statistical analysis by the Mann-Whitney test. As a result, self-medication was considered an option for 59 of the participants, most of them juniors, female, aged between 18 and 20, with no previous college degree, with medical insurance and aware of possible health risks, even after access to classes or online surveys. The clinical condition preceding self-medication included mainly headache, myalgia, fever, and allergies. There was a preference for anthelmintic, anti-inflammatory, analgesic, antipyretic medication, mainly antibiotics, and central nervous system stimulants. The habit of self-medication increases, gradually, during the graduation period, therefore is suggested the implementation of an educational campaign in the Biomedicine course curriculum to undo this cycle of chemical substance consumption.

Antipyretic Medication Exposures Among Young Children Reported to US Poison Centers, 2000-2015

This study used the National Poison Data System database to retrospectively analyze the characteristics and medical outcomes of exposures to antipyretic medications involving children younger than 6 years in the United States. From 2000 through 2015, United States Poison Control Centers recorded an average of 74 387 antipyretic exposures annually among children younger than 6 years. Most exposures involved ibuprofen (55.1%) or acetaminophen (40.1%). From 2000 to 2009, the number of exposures increased by 73.0%, followed by a 25.2% decrease from 2009 to 2015. Children exposed to acetaminophen had 1.98 times higher odds of a serious medical outcome compared with those exposed to ibuprofen. Although generally safe at the correct dosage, antipyretic exposures continue to cause pediatric morbidity and, in rare cases, death. Prevention efforts should focus on reducing child access; educating caregivers about the potential dangers of antipyretics; and discouraging their use, except when needed to improve a child’s comfort.

Population-level effects of suppressing fever

Fever is commonly attenuated with antipyretic medication as a means to treat unpleasant symptoms of infectious diseases. We highlight a potentially important negative effect of fever suppression that becomes evident at the population level: reducing fever may increase transmission of associated infections. A higher transmission rate implies that a larger proportion of the population will be infected, so widespread antipyretic drug use is likely to lead to more illness and death than would be expected in a population that was not exposed to antipyretic pharmacotherapies. We assembled the published data available for estimating the magnitudes of these individual effects for seasonal influenza. While the data are incomplete and heterogeneous, they suggest that, overall, fever suppression increases the expected number of influenza cases and deaths in the US: for pandemic influenza with reproduction number , the estimated increase is 1% (95% CI: 0.0–2.7%), whereas for seasonal influenza with , the estimated increase is 5% (95% CI: 0.2–12.1%).

Febrile Nonhemolytic Transfusion Reactions

Context.—Febrile nonhemolytic transfusion reactions (FNHTRs) cause unwelcome interruptions during the course of blood product transfusions and necessitate measures to verify the nature of the reaction and to exclude certain dangerous reactions, such as hemolytic and septic phenomena. Objective.—To examine transfusion medicine data to determine the clinical implications of the routine administration of antipyretic medication to adult patients before transfusion for the prevention of FNHTRs. Design.—A retrospective review was conducted of FNHTR data during 5 years (1998–2002), and a determination was made of the cost of a transfusion complicated by an FNHTR. In addition, a comparative cost analysis was performed using our data and published data on the incidence of FNHTRs. The clinical implications of medication with respect to possible drug-induced adverse effects were assessed, as well as the potential interference with diagnosing other forms of transfusion reactions and the mitigation of the clinical effect of an FNHTR. Results.—For nearly 120 000 U of transfused blood components, approximately 80% of which were preceded by antipyretic medication during the study period, the overall incidence of FNHTR was found to be 0.09%. Furthermore, there was no evidence of antipyretic-associated complications, nor any evidence that antipyretics prevented the recognition of other more dangerous complications of transfusions. Conclusion.—Our findings indicate that this practice provides significant advantages to the recipient of a transfusion, but does not appear to yield significant cost benefits for the health care provider.

National Patterns of Aspirin Use and Reye Syndrome Reporting, United States, 1980 to 1985

The number of cases of Reye syndrome reported annually to the Centers for Disease Control declined markedly between 1980 and 1985. In this article, we present pharmaceutical marketing research data that suggest sharp decreases in the use and purchase of children's aspirin between 1980 and 1985. These trends appear to correspond to the decrease in reporting of Reye syndrome cases. Additionally, analysis of physician mentions of aspirin and acetaminophen for treating flu and chickenpox showed statistically significant trends toward decreasing recommendations for the use of aspirin and significant trends toward increasing recommendations for use of acetaminophen. Trends in wholesale purchases of aspirin and acetaminophen by drug stores from 1979 through 1985 demonstrated a significant decline for the 81-mg children's aspirin tablet and an increase in purchases of children's acetaminophen products. Many factors may influence physician and parents' choice of analgesic/antipyretic medication, including information about Reye syndrome. Data suggest that a continuing decline in the use of aspirin for children may be accompanied by a continuing decline in the reported number of Reye syndrome cases.