Impact of Statins on Cognitive Deficits in Adult Male Rodents after Traumatic Brain Injury: A Systematic Review

The efficacy of statin treatment on cognitive decline is controversial, and the effect of statins on cognitive deficits in individuals with traumatic brain injury (TBI) has yet to be investigated. Therefore, we systematically reviewed the effect of statins on cognitive deficits in adult male rodents after TBI. After identifying eligible studies by searching four electronic databases on February 28, 2014, we assessed study quality, evaluated the efficacy of statin treatment, and performed stratified metaregression and metaregression to assess the influence of study design on statin efficacy. Eleven studies fulfilled our inclusion criteria from a total of 183 publications. The overall methodological quality of these studies was poor. Meta-analysis showed that statins exert statistically significant positive effects on cognitive performance after TBI. Stratified analysis showed that atorvastatin has the greatest effect on acquisition memory, simvastatin has the greatest effect on retention memory, and statin effects on acquisition memory are higher in closed head injury models. Metaregression analysis further showed that that animal species, study quality, and anesthetic agent impact statin effects on retention memory. We conclude that statins might reduce cognitive deficits after TBI. However, additional well-designed and well-reported animal studies are needed to inform further clinical study.

Research on the Automatic Ammeter Reading System and Its Application on the Intelligent Ecological Community Project

The Ultimate goal of property management in intelligent community lies in how to provide efficient and swift service with high quality. With the development of Science and Technology, Automatic Ammeter Reading System (RAARS) has made great improvement on Stability, accuracy and intelligence. The system with Automatic Ammeter for remote Reading is connected to property management center through Acquisition memory attached on the Bus using advanced sensing, electronics technologies based on traditional Mechanical instruments. As a result, managers can get the meter readings of central air conditioning, water, electricity, and gas of users from computer automatically which greatly decrease the labor force of workers and improve the management of property managing department.