Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature

New drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metastatic solitary fibrous tumor, we performed a systematic review of the literature encompassing the results of previous cardiac safety analysis published ten years ago, a review of clinical trials published during the last 10 years as well as single-case descriptions related to trabectedin cardiotoxicity. The estimated incidence of cardiac toxicity was 3,4% among patients receiving trabectedin, with recent data suggesting a higher rate of heart failure than previously recognized. Previous or concomitant anthracyclines exposure may represent a risk factor. Assaying for NT-pro-BNP may be useful for the early detection of individuals with trabectedin-induced heart failure.

Chryseobacterium bacteraemia in a patient with heart failure: case report and literature review

Background A 29-year-old male with recently diagnosed biventricular failure from myopericarditis and subsequent constrictive pericarditis on home milrinone presented to the Emergency Department with fevers/chills. Case summary On arrival to the Emergency Department, he was found to have septic shock and required vasopressor therapy. Chryseobacterium indologenes grew on his admission blood cultures, and he was treated with ciprofloxacin and piperacillin/tazobactam. He quickly improved, allowing for a successful pericardiectomy, was weaned off inotropes and discharged from the hospital. Discussion Chryseobacterium indologenes is an environmental Gram-negative rod found in groundwater. It is rarely associated with human infection, but is associated with indwelling lines and has been documented in immunocompromised patients. Treatment typically involves line removal and a fluoroquinolone or piperacillin/tazobactam; the most optimal antimicrobial regimen and duration of treatment are unknown.

Kajian Interaksi Obat pada Pasien Gagal Jantung Di RSUD Abdul Wahab Sjahranie Kota Samarinda

Cardiovascular diseases is first cause of death and heart failure is the end of all heart diseases and heart failure is causative factor enhancement of mortalities and morbidities heart failure patient. The purpose of the research is to know drug interaction in heart failure patient who undergoing hospitalization in RSUD Abdul Wahab Sjahranie in Samarinda. This research is non experimental and use retrospective to take a material during periods January – December in 2018. The result analyzed use descriptive evaluative and show heart failure case more suffer to the men (59.25%) at age 55-65 (35.80%) with the most of level education is senior high school (39.50%). The studies showed 163 drug interaction case with 18 (11.04%) minor interaction, 140(85.88%) moderate interaction and 5 (3.06%) major interaction.