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Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4814
Author(s):  
Ricardo G. Amaral ◽  
Silvana V. F. Gomes ◽  
Luciana N. Andrade ◽  
Sara A. dos Santos ◽  
Patrícia Severino ◽  
...  

Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.


2017 ◽  
Vol 16 (11) ◽  
pp. 1623-1630 ◽  
Author(s):  
Wei Zhu ◽  
Ying-Hua Gao ◽  
Chun-Hong Song ◽  
Zhi-Bin Lu ◽  
Tabbisa Namulinda ◽  
...  

Upon light activation, 13a can induce the production of PpIX in vivo which produces ROS and other reactive oxygen species to lead to the apoptosis of S180 cell tumors.


2012 ◽  
Vol 40 (04) ◽  
pp. 861-875 ◽  
Author(s):  
Jin-Hong Zhang ◽  
Dong-Ru Feng ◽  
Hong-Ling Ma ◽  
Bing Liu ◽  
Hong-Bin Wang ◽  
...  

Pinus massoniana bark extract (PMBE) is a mixture of flavonoids, and showed a capability of inducing cell apoptosis; however, its properties have not yet been fully investigated. This paper evaluates the antitumor effects of PMBE in murine sarcoma S180 both in vitro and in vivo. In vitro, the growth inhibition of S180 cells was concentration dependent on PMBE as shown by the CCK-8 assay. The AO/EB staining and flow cytometry assay showed that PMBE induced S180 cell apoptosis. Cell cycle analysis revealed that the cells in the S phase were decreased by treatment with PMBE. In vivo, the treatment of 100, 200, and 300 mg/kg PMBE reduced the tumor weight and volume of S180-bearing NIH mice by 9%–67% and 13%–68%, respectively. Peripheral leukocyte count and lymphoproliferation were increased significantly after treatment with PMBE. Our results suggest that PMBE inhibits the tumor cell growth by inducing cell apoptosis and improving lymphoproliferation.


2008 ◽  
Vol 254 (11) ◽  
pp. 3331-3338 ◽  
Author(s):  
Marshal Dhayal ◽  
Su-In Cho ◽  
Jun Young Moon ◽  
Su-Jin Cho ◽  
Anna Zykova

1983 ◽  
Vol 19 (8) ◽  
pp. 1133-1141 ◽  
Author(s):  
Jill M. Siegfried ◽  
Thomas R. Tritton ◽  
Alan C. Sartorelli
Keyword(s):  

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