Granular Cell Tumor of the Breast: Radiologic–Pathologic Correlation

Granular cell tumor (GCT) is an uncommon neoplasm arising from perineural Schwann cells that can arise anywhere in the body and is particularly rare in the breast. Imaging typically shows an irregular, noncalcified mass with high density on mammography and intense posterior shadowing on US that mimics malignancy. Benign GCTs can be locally aggressive and invade the skin or chest wall. Core biopsy is necessary for diagnosis. Polygonal- to spindle-shaped cells with prominent cytoplasmic eosinophilic granules show S-100 and CD68 staining on immunohistochemistry and lack cytokeratin, estrogen, or progesterone expression. The vast majority of GCTs are benign, albeit locally infiltrative, tumors cured by wide local excision.

Sudden Death from Primary Cerebral Melanoma: Clinical Signs and Pathological Observations

Primary cerebral tumors rarely provoke sudden death. The incidence is often underestimated with reported frequencies in the range of 0.02 to 2.1% in medicolegal autopsy series. Furthermore, primary cerebral melanoma is an uncommon neoplasm. It represents approximately 1% of all melanoma cases and 0.07% of all brain tumors. This neoplasm is very aggressive, and its annual incidence is about 1 in 10 million people. In the present study, a 20-year-old male was admitted to hospital with vomiting, headache, paresthesia and aggressive behavior. A computed tomography (CT) scan of the head was performed showing a hyperdense nodule in the right parietal lobe with inflammation of the Silvian fissure. A complete autopsy was performed 48 h after death. A blackish material was displayed on the skull base, and posterior fossa. Microscopic examination diagnosed primary brain melanoma. A systematic review of the literature was also performed where no previous analogous cases were found. The forensic pathologist rarely encounters primary cerebral melanoma, and for these reasons, it seemed appropriate to describe this case as presenting aspecific clinical symptoms and leading to sudden unexpected death. Histopathological observations are reported and discussed to explain this surprising sudden death caused by a primary cerebral melanoma.

A RARE OCCURRENCE OF ESOPHAGEAL SPINOCELLULAR CARCINOMA IN A YOUNG ADULT

Esophageal squamous cell carcinoma is a relatively uncommon neoplasm that affects advanced age groups. Here we report a case of an invasive esophageal squamous cell carcinoma that affected a 17-year-old male patient with some evidence showing that the early stages of neoplastic development were throughout childhood. No risks factors were identified and the patient had an excellent long-term outcome.

Bilateral Bizarre Vulvar Swellings in a Teenager: A very rare Entity of Aggressive Angiomyxoma

Background: Aggressive angiomyxoma (AA) is a rare mesenchymal neoplasm that commonly occurs in perineal region of females. Case Report: A 17 years female presents with bilateral bizarre vulvar swellings, gradually increasing in size for 2 years, painful for 1 week. Sonographic evaluation revealed bilateral well-defined hypoechoic lesions with internal vascularity and cystic areas. Magnetic resonance imaging (MRI) demonstrated these lesions to be iso-intense to skeletal muscles on T1-weighted images (T1WI) and hyperintense on T2-weighted images (T2WI). These were surgically excised and sent for histopathology that confirmed these lesions to be AA. Discussion: AA is an uncommon neoplasm of mesenchymal origin that arises mainly in the perineal soft tissue of adults. It occurs predominantly in females with a peak incidence in fourth decade. [1] In our case the patient was a teenager. In females it may present as a vulvar nodule, polyp or may even be mistaken for a Bartholin’s or labial cyst. In males it involves analogous sites including inguino-scrotal region. [4] Most of the reported cases include solitary unilateral lesions. Conclusion: Our case is unique because the patient was in her teenage and presented with bilateral vulvar angiomyxomas that showed internal vessels on colour doppler imaging.

Giant cell tumor of soft tissue originating from the thyroid: a case report and literature review

Background: Giant cell tumor of soft tissues (GCT-ST) is a low malignant uncommon neoplasm, with is histological and immunophenotype similar to that of GCT of bone. Primary giant cell tumor of soft tissue arising in the thyroid is exceedingly rare. Case presentation: We reported a new case of GCT-ST originating from the thyroid occurring in 69-year-old woman. Histologically, the tumor was composed of two morphological components, mononuclear cells admixed with multinucleated osteoclast-like giant cells. Tumor is devoid of atypia, pleomorphism, and atypical mitosis. Immunohistochemically, the tumor cells showed strongly positivity with antibodies to CD68, but were negative for AE1/AE3, EMA and additional muscle markers. Conclusions: Due to its rare occurrence, we analyzed the clinical features of patients with primary thyroid GCT-ST to summarize some of our experiences and conduct a literature. The interest of this case lies in the rarity of this entity, the difficulty in preoperative diagnosis, and the confusion with other malignancies.

A Rare De Novo Myoepithelial Carcinoma Ex Pleomorphic Adenoma in a Young Woman

Carcinoma ex pleomorphic adenoma, an uncommon neoplasm of the parotid gland, accounts for less than 4% of salivary gland tumors. It arises from a benign pleomorphic adenoma presenting in the sixth to eighth decades of life. We present this as a unique account of a primary parotid gland carcinoma, arising from myoepithelial cells, without a known precursor lesion, in a 28-year-old woman. This presentation seeks to provide familiarity of an unusual presentation of an unexpected rare pathology in a young female patient and the tools utilized for an accurate diagnosis.

Long-term survival in a cat with pancreatic adenocarcinoma treated with surgical resection and toceranib phosphate

Case summary Primary pancreatic adenocarcinoma is an uncommon neoplasm seen in cats and often has a poor prognosis. We report a case of an 8-year-old male neutered domestic shorthair cat weighing 5.8 kg diagnosed with pancreatic adenocarcinoma treated with surgical resection and toceranib phosphate, which had a progression-free interval of 1148 days and survived for more than 1436 days. The treatment was well tolerated; however, the cat developed generalised coat hypopigmentation. Relevance and novel information To our knowledge, the cat in our report has the longest progression-free interval and survival time post-surgical resection of pancreatic carcinoma treated with toceranib. Hypopigmentation as a side effect of toceranib has been reported in dogs, but this is the first case reported in cats.