viral exacerbation
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Double-stranded RNA evokes exacerbation in a mouse model of corticosteroid refractory asthma

2015 ◽  
Vol 129 (11) ◽  
pp. 973-987 ◽  
Author(s):  
Jorge De Alba ◽  
Raquel Otal ◽  
Elena Calama ◽  
Anna Domenech ◽  
Neus Prats ◽  
...  
Keyword(s):  
Mouse Model ◽  
Asthma Exacerbation ◽  
Airway Hyperreactivity ◽  
Asthma Phenotype ◽  
Double Stranded Rna ◽  
Cytokines And Chemokines ◽  
Set Up ◽  
Refractory Asthma ◽  
Viral Exacerbation ◽  
Pro Inflammatory Cytokines

We have set up a new murine model mimicking aspects of viral exacerbation in a corticosteroid-refractory asthma phenotype. Our model shows an exacerbation of airway hyperreactivity, enhanced inflammation and elevated pro-inflammatory cytokines and chemokines associated with human asthma exacerbation.

scholarly journals Axl Receptor Blockade Ameliorates Pulmonary Pathology Resulting from Primary Viral Infection and Viral Exacerbation of Asthma

2014 ◽  
Vol 192 (8) ◽  
pp. 3569-3581 ◽  
Author(s):  
Takehiko Shibata ◽  
David M. Habiel ◽  
Ana L. Coelho ◽  
Steven L. Kunkel ◽  
Nicholas W. Lukacs ◽  
...  
Keyword(s):  
Viral Infection ◽  
Receptor Blockade ◽  
Pulmonary Pathology ◽  
Viral Exacerbation

scholarly journals Viral exacerbation of chronic airway inflammation in BALB/c mice sensitized with house dust mite (HDM): a role for corticosteroids?

2013 ◽  
Vol 10 (Suppl 1) ◽  
pp. P41 ◽  
Author(s):  
Edward G Barrett ◽  
Al P Senft ◽  
Jennifer Nicodem ◽  
Dylan Armes ◽  
Aaron Gaskins ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
House Dust ◽  
House Dust Mite ◽  
Dust Mite ◽  
Viral Exacerbation ◽  
Chronic Airway

scholarly journals A COPD-like model of viral exacerbation: synergistic effects with smoke and poly I:C

2013 ◽  
Vol 10 (Suppl 1) ◽  
pp. P34
Author(s):  
F Schlerman ◽  
J Kubera ◽  
M Fleming ◽  
K Nocka ◽  
C Williams
Keyword(s):  
Synergistic Effects ◽  
Poly I:C ◽  
Viral Exacerbation

scholarly journals S128 The Extrinsic Coagulation Pathway is Locally Upregulated in an Experimental Model of Viral Exacerbation of Pulmonary Fibrosis

Thorax ◽  
2012 ◽  
Vol 67 (Suppl 2) ◽  
pp. A61.2-A61
Author(s):  
N Smoktunowicz ◽  
R Alexander ◽  
L Franklin ◽  
AE Williams ◽  
G Jarai ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Experimental Model ◽  
Coagulation Pathway ◽  
Viral Exacerbation

scholarly journals Molecular and cellular mechanisms in the viral exacerbation of asthma

2008 ◽  
Vol 10 (9) ◽  
pp. 1014-1023 ◽  
Author(s):  
Sharyn Tauro ◽  
Yung-Chang Su ◽  
Sandra Thomas ◽  
Jürgen Schwarze ◽  
Klaus I. Matthaei ◽  
...  
Keyword(s):  
Cellular Mechanisms ◽  
Viral Exacerbation
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