medaka embryo
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Author(s):  
Musa Adamu Ibrahim ◽  
Syaizwan Zahmir Zulkifli ◽  
Mohammad Noor Amal Azmai ◽  
Ferdaus Mohamat-Yusuff ◽  
Ahmad Ismail

Some herbicides exert hormetic or biphasic non-monotonic dose-response (NMDR), which is one of the major challenges for ecological risk assessment (ERA) of pesticides pollution. In this study, fish embryo toxicity test (FET) with Javanese medaka (Oryzias javanicus) to sublethal concentration of diuron was determined. Inverted U-shape heart rate was observed at 3 days post-exposure (dpe) and 7 dpe. However, at 13 dpe the heart rate (104 ± 2.90 heartbeat/min.) decreased in 10.00 mg.L-1 exposed-embryos. At 20 dpe, hatchability and survival rate were reduced in 5.00 mg.L-1 and 10.00 mg.L-1 exposed groups. Hormetic developmental deformities were observed in embryo-larvae of Javanese medaka. The results revealed a biphasic effect of low concentrations of diuron on some morphological and physiological features of Javanese medaka embryo-larvae, which might be attributed to endocrine disruption of this herbicide. Further studies to support these effects were recommended.


Epigenetics ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 611-622 ◽  
Author(s):  
Xuegeng Wang ◽  
Ramji Kumar Bhandari

2019 ◽  
Vol 105 ◽  
pp. 157-168 ◽  
Author(s):  
Diane Genest ◽  
Elodie Puybareau ◽  
Marc Léonard ◽  
Jean Cousty ◽  
Noémie De Crozé ◽  
...  

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 475
Author(s):  
Santu Singha ◽  
Ilias Muhammad ◽  
Mohamed Ibrahim ◽  
Mei Wang ◽  
Nicole Ashpole ◽  
...  

Although 4-O-Methylhonokiol (MH) effects on neuronal and immune cells have been established, it is still unclear whether MH can cause a change in the structure and function of the cardiovascular system. The overarching goal of this study was to evaluate the effects of MH, isolated from Magnolia grandiflora, on the development of the heart and vasculature in a Japanese medaka model in vivo to predict human health risks. We analyzed the toxicity of MH in different life-stages of medaka embryos. MH uptake into medaka embryos was quantified. The LC50 of two different exposure windows (stages 9–36 (0–6 days post fertilization (dpf)) and 25–36 (2–6 dpf)) were 5.3 ± 0.1 μM and 9.9 ± 0.2 μM. Survival, deformities, days to hatch, and larval locomotor response were quantified. Wnt 1 was overexpressed in MH-treated embryos indicating deregulation of the Wnt signaling pathway, which was associated with spinal and cardiac ventricle deformities. Overexpression of major proinflammatory mediators and biomarkers of the heart were detected. Our results indicated that the differential sensitivity of MH in the embryos was developmental stage-specific. Furthermore, this study demonstrated that certain molecules can serve as promising markers at the transcriptional and phenotypical levels, responding to absorption of MH in the developing embryo.


2016 ◽  
Vol 35 (9) ◽  
pp. 2270-2280 ◽  
Author(s):  
Badreddine Barhoumi ◽  
Christelle Clérandeau ◽  
Laure Landi ◽  
Anaïk Pichon ◽  
Florane Le Bihanic ◽  
...  
Keyword(s):  

2016 ◽  
Vol 2016 (0) ◽  
pp. A221
Author(s):  
Toru Nako ◽  
Nao Ninomiya ◽  
Masaru Matsuda

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