histatin 8
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Author(s):  
Pandurangan Perumal ◽  
Mani Vasudevan ◽  
Sridevi Chigurupati ◽  
Manikandan Selvaraj

Objective: To evaluate the octapeptides related to human histatin 8 by in-silico and in-vitro studies.Method: Schrodinger, LLC and Ellman’s method.Results: The compound HH1 and HH2 was found to be potent docking score of −9.494 and −7.401 against acetylcholinesterase (AChE) enzyme. The IC50 value of HH1 and HH2 was found to be 0.39±0.28 and 0.78±0.15 μg/mL. However, these compounds are shown to be highly effective as compared with the control AChE inhibitor donepezil (0.065±0.0050 μg/mL).Conclusion: In-silico docking study was conducted for the designed octapeptides related to human histatin 8 against AChE enzyme shows significance binding affinity toward HH1 and HH2 peptides and the AChE inhibitory activity of octapeptides shown to be a highly potent inhibitor as compared with control donepezil.


2001 ◽  
Vol 8 (6) ◽  
pp. 295-307 ◽  
Author(s):  
Savita Tauro ◽  
Evans Coutinho ◽  
Sudha Srivastava

1993 ◽  
Vol 43 (2) ◽  
pp. 221-223 ◽  
Author(s):  
Yukitaka MURAKAMI ◽  
Hideki NAGATA ◽  
Satoshi SHIZUKUISHI ◽  
Akira TSUNEMITSU

1992 ◽  
Vol 42 (3) ◽  
pp. 406-408
Author(s):  
Yukitaka MURAKAMI ◽  
Atsuo AMANO ◽  
Satoshi SHIZUKUISHI ◽  
Akira TSUNEMITSU
Keyword(s):  

1992 ◽  
Vol 42 (5) ◽  
pp. 689-695 ◽  
Author(s):  
Yukitaka MURAKAMI ◽  
Satoshi SHIZUKUISHI ◽  
Akira TSUNEMITSU ◽  
Kazuhisa NAKASHIMA ◽  
Yukio KATO ◽  
...  

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