Application of Trimethylsilanolate Alkali Salts in Organic Synthesis

Trimethylsilanolate alkali salts are widely used in organic synthesis, mainly due to their solubility in common organic solvents. They are frequently used as nucleophiles in ester hydrolysis, both in solution and solid-phase chemistry. However, they have also been used as mild bases or as specific reagents in some chemical transformations. Reactions employing trimethylsilanolate alkali salts as the key component are typically performed under mild reaction conditions. This review summarizes the utilization of trimethylsilanolate alkali salts in various organic transformations.1 Introduction2 Properties of Alkali Metal Trimethylsilanolates (TMSO[M])3 Trimethylsilanolate Alkali Salts in Organic Synthesis4 Conclusion

Synthesis and study of novel pH-independent fluorescent mitochondrial labels based on Rhodamine B

Several Rhodamine B derivatives based on a tri-substituted pyrimidine core were prepared using solid-phase chemistry. Some derivatives exhibited fluorescence also at high pH and showed significant mitochondrial localization.