tyrphostin ag1478
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scholarly journals BML-265 and Tyrphostin AG1478 Disperse the Golgi Apparatus and Abolish Protein Transport in Human Cells

2019 ◽  
Vol 7 ◽  
Author(s):  
Gaelle Boncompain ◽  
Nelly Gareil ◽  
Sarah Tessier ◽  
Aurianne Lescure ◽  
Thouis R. Jones ◽  
...  
Keyword(s):  
Golgi Apparatus ◽  
Protein Transport ◽  
Human Cells ◽  
Tyrphostin Ag1478

scholarly journals Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα

2016 ◽  
Vol 60 (10) ◽  
pp. 6402-6406 ◽  
Author(s):  
Cristina M. Dorobantu ◽  
Christian Harak ◽  
Rahel Klein ◽  
Lonneke van der Linden ◽  
Jeroen R. P. M. Strating ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Growth Factor Receptor ◽  
Encephalomyocarditis Virus ◽  
Genome Replication ◽  
Chemotherapy Agent ◽  
Epidermal Growth ◽  
Phosphatidylinositol 4 ◽  
Tyrphostin Ag1478

ABSTRACTEncephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, bothin vitroand in cells. AG1478 impaired replication of EMCV and HCV but not that of an EMCV mutant previously shown to escape PI4KA inhibition. This work uncovers novel cellular and antiviral properties of AG1478, a compound previously regarded only as a cancer chemotherapy agent.

The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress

2012 ◽  
Vol 46 (11) ◽  
pp. 1393-1405 ◽  
Author(s):  
Yang Yu ◽  
Si-Miao Fan ◽  
Yuan-Chao Ye ◽  
Shin-ichi Tashiro ◽  
Satoshi Onodera ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Apoptosis ◽  
A431 Cell ◽  
Tyrphostin Ag1478

The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms

2011 ◽  
Vol 82 (11) ◽  
pp. 1583-1592 ◽  
Author(s):  
Laia Caja ◽  
Patricia Sancho ◽  
Esther Bertran ◽  
Conrad Ortiz ◽  
Jean S. Campbell ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Liver Tumor ◽  
Egf Receptor ◽  
Tyrphostin Ag1478

Analysis of tyrphostin AG1478 effect on behavior of internalized EGF receptor at different stages of endocytosis

2009 ◽  
Vol 3 (5) ◽  
pp. 454-460
Author(s):  
K. A. Kondratov ◽  
A. L. Chernorudskiy ◽  
A. P. Amosova ◽  
E. S. Kornilova
Keyword(s):  
Egf Receptor ◽  
Tyrphostin Ag1478

Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG1478-mesylate, with albumin

2005 ◽  
Vol 342 (2) ◽  
pp. 292-299 ◽  
Author(s):  
Andrew H.A. Clayton ◽  
Matthew A. Perugini ◽  
Janet Weinstock ◽  
Julie Rothacker ◽  
Keith G. Watson ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Analytical Ultracentrifugation ◽  
Kinase Inhibitor ◽  
Tyrphostin Ag1478
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